Summary
Following an intramuscular dose of 5.0 mg of tobramycin in eight full-term newborn infants, peak levels averaging 2.69 ± 0.70µg/ml were attained after 30 to 60 minutes. The serum half-life thereafter correlated inversely to postnatal age during the first seven days after birth. Pharmacokinetic analysis revealed that in newborn infants the elimination rate was markedly declined, but the absorption rate was nearly the same as that in older children. Average urinary recovery within eight hours was as low as 26.8%, which suggested accumulation of this antibiotic in the renal tissue.
Zusammenfassung
Bei reifen Neugeborenen betrug nach einer einmaligen Dosis von 5 mg Tobramycin i.m. die maximale Serumkonzentration im Mittel 2,69 ± 0,70µg/ml; sie wurde nach 30–60 Minuten erreicht. Danach korrelierte die Serum-Halbwertzeit innerhalb der ersten sieben Lebenstage reziprok mit dem Lebensalter. Die pharmakokinetische Analyse zeigte, daß bei Neugeborenen die Eliminationsrate wesentlich kleiner, die Absorptionsrate jedoch annähend gleich groß war wie bei einem älteren Kind. Die durchschnittliche Urin-Recovery innerhalb der ersten acht Stunden betrug nur 26,8%, was auf eine Akkumulation des Medikamentes im Nierengewebe hinzuweisen scheint.
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Yoshioka, H., Takimoto, M., Fujita, K. et al. Pharmacokinetics of tobramycin in the newborn. Infection 7, 180–182 (1979). https://doi.org/10.1007/BF01640938
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DOI: https://doi.org/10.1007/BF01640938