Skip to main content
SpringerLink
Log in

Die Bindung von Erythromycin an Serumproteine des Menschen bei verschiedenen Infektionen

The binding of erythromycin to proteins in the serum of humans during various infections

  • Published:
Infection Aims and scope Submit manuscript

Zusammenfassung

Saures α1-Glycoprotein bindet konzentrationsabhängig den größten Anteil des Erythromycins im Serum. Die Konzentration des sauren α1-Glycoproteins kann bei Infektionen erhöht sein; damit nimmt die Bindung des Erythromycins zu und der freie Antibiotika-Anteil ab.

Summary

A large amount of the erythromycin in the serum is bound to acidic α1-glycoprotein; the exact share is dependent on the concentration. The concentration of acidic α1-glycoprotein can be elevated during infections. Thus, a larger amount of the erythromycin is bound, leaving less free antibiotic.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Dette, G. A. Serum and tissue concentrations of erythromycin: a review. Curr. Med. Res. Opinion 6, Suppl. 8 (1980) 23–28.

    Google Scholar 

  2. Tillement, J. P., Campos y Sansano, H., d'Athis, P., Prandota. J.: Liaisons aux protéines plasmatiques humaines, interactions médicamenteuses. Etudein vitro avec l'érythromycine base marquée au carbone 14. Gaz. Méd. France Suppl. (Monograph. thérapeutiques) L'érythromycine aujourd'hui et demain, 1978 pp. 38–43.

Download references

Author information

Authors and Affiliations

  1. Pharmacology, Faculté de Médecine de Creteil, Département de Pharmacologie, 8, Rue du Général Sarrail, F-94010, Creteil, France

    J. Barré Master of Science

  2. Biochemistry, Faculté de Médecine de Creteil, Département de Pharmacologie, 8, Rue du Général Sarrail, F-94010, Creteil, France

    R. Zini Master of Science

  3. Faculté de Médecine de Creteil, Département de Pharmacologie, Biologiste des Hôpitaux, 8, Rue du Général Sarrail, F-94010, Creteil, France

    J. P. Tillement (Professeur de Pharmacologie)

Authors
  1. J. Barré Master of Science
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Zini Master of Science
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. P. Tillement
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Barré, J., Zini, R. & Tillement, J.P. Die Bindung von Erythromycin an Serumproteine des Menschen bei verschiedenen Infektionen. Infection 10 (Suppl 2), S113–S115 (1982). https://doi.org/10.1007/BF01640868

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01640868

Search

Navigation