Summary
In a double blind, randomized study, sulfamethoxazole was compared alone and in combination with trimethoprim as commonly used in therapeutic regimes for the treatment of uncomplicated acute urinary tract infections in outpatients. The cure rate of sulfamethoxazole alone was 92.2%, and for sulfamethoxazole plus trimethoprim 97.6%. The rate of side-effects for the former was 5%, for the latter 21.8%. If the failure rate plus the rate of occurrence of rash, which necessitated discontinuing the drug, are combined, it appears that 8.8% of the patients were at a disadvantage receiving sulfamethoxazole compared to 9.7% for the combination of sulfamethoxazole plus trimethoprim. When considering the cure rate and rate of side-effects together, therefore, the position of sulfamethoxazole alone as a suitable drug in this type of infection is defended.
Zusammenfassung
In einer randomisierten Doppelblindstudie wurde Sulfamethoxazol allein und in Kombination mit Trimethoprim, wie es allgemein in Therapieschemata für die Behandlung der unkomplizierten Harnwegsinfektionen gebraucht wird, untersucht. Die Heilungsrate von Sulfamethoxazol allein betrug 92,9% und von Sulfamethoxazol plus Trimethoprim 97,6%. Die Rate an Nebenwirkungen für das erstere betrug 5%, für das letztere 21,8%. Wenn die Versagerraten mit der Rate an Exanthemen kombiniert werden, die ein Absetzen des Medikamentes erforderlich machten, dann sieht es so aus, daß 8,8% der Patienten nachteilige Erfahrungen machten, die Sulfamethoxazol erhielten, verglichen mit 9,7% von denen, die die Kombination von Sulfamethoxazol plus Trimethoprim erhielten. Wenn die Heilungsrate und Nebenwirkungsrate zusammen betrachtet werden, ist die Bedeutung des Sulfamethoxazol allein als geeignetes Medikament für diese Art von Infektionen belegt.
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Bergan, T., Skjerven, O. Comparison of sulfamethoxazole alone and combined with trimethoprim in urinary tract infections. Infection 7, 14–16 (1979). https://doi.org/10.1007/BF01640549
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DOI: https://doi.org/10.1007/BF01640549