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Double-blind comparison of sulphonamide-trimethoprim combinations in acute uncomplicated urinary tract infections

Doppelblindvergleich von Sulfonamid-Trimethoprim Kombinationen bei akuten, unkomplizierten Harnwegsinfektionen

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Summary

The effects of a twice daily dosage of a combination of 410 mg sulphadiazine + 90 mg trimethoprim (SD + TMP) and 800 mg sulphamethoxazole + 160 mg trimethoprim (SMZ + TMP) were compared in uncomplicated urinary tract infections. All but one patient in each treatment group, i.e. 36 SD + TMP treated and 42 SMZ + TMP treated patients respectively, were cured. The percentage of side-effects related to therapy in the patients receiving the combination with sulphadiazine was 15.1% and in those with sulphamethoxazole 23.7%. Due to the small number tested, however, differences were not statistically different. It is noteworthy that only one of the SD + TMP patients had to stop therapy because of a rash, whereas therapy was stopped for this reason in three of the SMZ + TMP patients. SD + TMP represents a good alternative to SMZ + TMP in the treatment of urinary tract infections.

Zusammenfassung

Die Wirksamkeit einer Kombination von 410 mg Sulphadiazin + 90 mg Trimethoprim (SD + TMP) und 800 mg Sulphamethoxazol + 160 mg Trimethoprim (SMZ + TMP) bei zweimaliger Verabreichung/die wurde bei unkomplizierten Harnwegsinfektionen verglichen. In jeder Behandlungsgruppe wurden alle bis auf einen Patienten geheilt, d. h. 36 SD- + TMP-Behandelte und 42 SMZ- + TMP-Behandelte. Der Prozentsatz an mit der Therapie verbundenen Nebenwirkungen war bei den Patienten, die die Kombination mit Sulfadiazin erhielten 15,1% und bei denen, die Sulfamethoxazol erhielten 23,7%. Wegen der kleinen Fallzahl waren jedoch diese Unterschiede statistisch nicht belegbar. Es ist bemerkenswert, daß nur einer der SD- + TMP-Patienten die Therapie wegen eines Exanthems unterbrechen mußte, während dies bei drei der SMZ- + TMP-Patienten geschah. SD + TMP stellt eine gute Alternative für SMZ + TMP bei Harnwegsinfektionen dar.

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Authors and Affiliations

  1. National Health Service, Tromsø District, Norway

    O. Skjerven

  2. Departments of Microbiology, Institute of Pharmacy, University of Oslo, and University Hospital, Tromsø, Norway

    T. Bergan

Authors
  1. O. Skjerven
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  2. T. Bergan
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Skjerven, O., Bergan, T. Double-blind comparison of sulphonamide-trimethoprim combinations in acute uncomplicated urinary tract infections. Infection 7 (Suppl 4), S398–S400 (1979). https://doi.org/10.1007/BF01639020

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