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Differentiation of anti-Pr1-and anti-Pr2-sera with periodate-oxidized erythrocyte glycoproteins

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Summary

Human erythrocyte glycoproteins represent the MN and the Pr1/Pr2 antigens. MN and Pr1/Pr2 are determined by terminal N-acetylneuraminic acid of these glycoproteins. By periodate oxidation of red cell glycoproteins resulting in neuraminic acid with shortened polyhydroxy side chain, the Pr1 and MN antigens are inactivated. In contrast to this, the Pr2 antigenicity is strongly increased.

Zusammenfassung

Die Erythrozytenglykoproteine des Menschen enthalten die Antigene MN und Pr1/Pr2. Diese Antigene werden durch terminale N-Acetyl-Neuraminsäure determiniert. Durch Perjodatoxydierung der Erythrozytenglykoproteine, die eine Verkürzung der Neuraminsäure-Polyhydroxyseitenkette bewirkt, werden die Antigene Pr1 und MN maktiviert, während die Pr2-Antigenität stark zunimmt.

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Author notes

  1. Elwira Lisowska

    Present address: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Chalubinskiego 4, Wroclaw, Poland

  2. Dieter Roelcke

    Present address: Institute of Immunologie and Serologie of the University of Heidelberg-BRD, Voss-Str. 2, D-6900, Heidelberg, Germany

Authors and Affiliations

  1. Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Chalubinskiego 4, Wroclaw, Poland

    Dieter Roelcke

  2. Institute of Immunologie and Serologie of the University of Heidelberg-BRD, Voss-Str. 2, D-6900, Heidelberg, Germany

    Elwira Lisowska

Authors
  1. Elwira Lisowska
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  2. Dieter Roelcke
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Lisowska, E., Roelcke, D. Differentiation of anti-Pr1-and anti-Pr2-sera with periodate-oxidized erythrocyte glycoproteins. Blut 26, 339–341 (1973). https://doi.org/10.1007/BF01638700

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  • DOI: https://doi.org/10.1007/BF01638700

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