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Bone Marrow Transplantation in Children with Aplastic Anemia and Acute Lymphatic Leukemia

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Summary

A boy with severe Aplastic Anemia (AA) and a girl with Acute Lymphoblastic Leukemia (ALL) in relapse have been grafted with marrow from HL-A identical, mixed leukocyte culture (MLC) negative siblings after appropriate immunosuppressive and antileukemic therapy. Both of them are well 7 and 2 months after transplantation respectively. Bone marrow transplantation should be considered in children with AA and ALL in relapse, if HL-A identical, MLC negative sibling are available.

Zusammenfassung

Ein Junge mit schwerer Knochenmarkaplasie und ein Mädchen mit rezidivierender akuter lymphatischer Leukämie wurden nach entsprechender immunsuppressiver und antileukämischer Vorbehandlung mit Knochenmark von HL-A-identischen, MLC-negativen Geschwistern transplatiert. Beide Kinder sind 7 bzw. 2 Monate nach Knochenmarkaplasie oder akuter lymphatischer Leukämie im Rezidiv in Betracht gezogen werden, wenn HL-A-identische, MLC-negative Geschwister zur Verfügung stehen.

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Abbreviations

AA:

Aplastic Anemia

ALL:

Acute lymphatic leukemia

ATG:

Anti-thymus globulin

GVHD:

Graft-versus-host disease

MLC:

Mixed leukocyte culture

RATG:

Rabbit-anti-thymus globulin

References

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Author information

Author notes

  1. H. -J. Kolb

    Present address: Abteilung Immunologie, Institut für Hämatologie der Gesellschaft für Strahlen-und Umweltforschung mbH, Landwehrstr. 61, 8000, München 2

Authors and Affiliations

  1. Abteilung Immunologie, Institut für Hämatologie der Gesellschaft für Strahlen-und Umweltforschung mbH, Landwehrstr. 61, 8000, München 2

    G. Brehm, H. Rodt, H. Grosse-Wilde, E. Thiel, W. Ruppelt & S. Thierfelder

  2. Kinderkrankenhaus München-Schwabing, München, Deutschland

    I. Spitzer

  3. Kinderklinik und Kinderpoliklinik der Technischen Universität München, München, Deutschland

    G. F. Wündisch

  4. Kinderpoliklinik der Universität München, München, Deutschland

    Ch. Bender-Götze & E. D. Albert

  5. Klinik und Poliklinik für Radiologie München, München, Deutschland

    H. v. Lieven

  6. Gemeinsame Einrichtung “Angewandte Physik” des Instituts für Biologie der Gesellschaft für Strahlen-und Umweltforschung mbH, München, Deutschland

    O. Balk

  7. Sonderforschungsbereich 37 der Universität München, München, Deutschland

    G. Brehm

Authors
  1. H. -J. Kolb
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  2. G. F. Wündisch
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  3. Ch. Bender-Götze
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  4. I. Spitzer
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  5. G. Brehm
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  6. H. Rodt
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  7. H. v. Lieven
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  8. H. Grosse-Wilde
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  9. E. D. Albert
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  10. E. Thiel
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  11. W. Ruppelt
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  12. O. Balk
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  13. S. Thierfelder
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Kolb, H.J., Wündisch, G.F., Bender-Götze, C. et al. Bone Marrow Transplantation in Children with Aplastic Anemia and Acute Lymphatic Leukemia. Blut 31, 343–346 (1975). https://doi.org/10.1007/BF01633999

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  • DOI: https://doi.org/10.1007/BF01633999

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