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Pathology of modified graft-versus-host disease in bone marrow allografted monkeys treated with antilymphocyte serum

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Summary

Lethally irradiated rhesus monkeys were used for bone marrow allografting and autografting. Monkeys receiving allogeneic bone marrow developed acute graftversus-host reaction (GVHR) and had a mean survival time of 9.1 days as compared to autografted monkeys which survived above 500 days. Treatment with antilymphocyte sera (ALS) before allografting modified the GVHR and extended the survival time to an average of 43 days. Histologically, such animals showed evidence of “chronic” GVHR and septicemia secondary to a lack in lymphoreticular recovery. Subsequently, severe GI-tract infections followed which usually served as portal of entry for septicemia.

Zusammenfassung

Pathologie der modifizierten graft-versus-host-Krankheit des Rhesusaffen bei Knochenmark-Allotransplantation und Behandlung mit anti-Lymphozytenserum: Rhesusaffen wurden nach letaler Bestrahlung mittels Röntgenstrahlen und60Co mit Knochenmark-Allo- oder Autotransplantat behandelt. Der Allotransplantation folgte eine letale graft-versus-host-Reaktion (GVHR) mit einer mittleren Überlebenszeit von 9,1 Tagen; autotransplantierte Tiere ohne GVHR überlebten mehr als 500 Tage. Behandlung mit anti-Lymphozytenserum vor Übertragung allogenen Markes führte zu einer Verlängerung der Überlebenszeit bis zum Mittel von 43 Tagen. Diese Tiere zeigten histologische Zeichen einer “chronischen” GVHR und Sepsis als Folge einer mangelhaften Rekonstitution des lymphoretikulären Systems. Im Rahmen dieser “Defektheilung” kam es zu schweren bakteriellen Darmerkrankungen, die offenbar als Eintrittspforte für septische Allgemeininfektionen dienten.

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Author notes

  1. Gerhard R. F. Krueger

    Present address: Pathology Institute, University of Köln, Köln, BRD

Authors and Affiliations

  1. Experimental Hematology Section, Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA

    Gerhard R. F. Krueger, Robert G. Graw Jr., G. Nicholas Rogentine, Charles C. Darrow II, John R. Neefe & Josef Luetzeler

  2. Pathology Institute, University of Köln, Köln, BRD

    Robert G. Graw Jr., G. Nicholas Rogentine, Charles C. Darrow II, John R. Neefe & Josef Luetzeler

Authors
  1. Gerhard R. F. Krueger
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  2. Robert G. Graw Jr.
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  3. G. Nicholas Rogentine
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  4. Charles C. Darrow II
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  5. John R. Neefe
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  6. Josef Luetzeler
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Additional information

This is a publication of the Cooperative Bone Marrow Transplantation Group; the collaboration of following participating members is appreciated: B. M.Ulland, C. B.Merritt, M. G.Valerio, W. F.Loeb.

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Krueger, G.R.F., Graw, R.G., Rogentine, G.N. et al. Pathology of modified graft-versus-host disease in bone marrow allografted monkeys treated with antilymphocyte serum. Blut 30, 19–30 (1975). https://doi.org/10.1007/BF01633783

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  • DOI: https://doi.org/10.1007/BF01633783

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