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Experimental models of kidney tumors

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Abstract

We here present in outline some outstanding results on the animal models of renal tumors submitted to the highest attention, which include two kinds of epithelial neoplams: those developed from the epithelium lining each the renal tubules (renal cell tumors) and pelvis; the mesenchymal tumor of rat; and tumors with embryonal appearance: the nephroplastoma as well as the variant of it known as the estrogen-induced tumor in the hamster. The review deals with methods for tumor induction and the pathobiology of tumors, the latter mainly focussed on the indendification of the precise types of renal cells committed in tumor origin. The existence of closely related counterparts of these animal tumors in man is also emphasized, by representing a situation of great potentiality, already exploited, to improve understanding of both the nature and development of renal tumors in man.

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Abbreviations

RCT:

renal cell tumors

RPET:

renal pelvis epithelium tumors

RMT:

renal mesenchymal tumor

ERHT:

estrogen-induced renal tumors of the hamster

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Authors and Affiliations

  1. Department of Pathology, Medical School, University of Valencia, Spain

    Enrique Nogueira

  2. Department of Pathology, Medical School, University of Barcelona, Spain

    Antonio Cardesa

  3. Institute of Experimental Pathology, Medizinische Hochschule, Hannover, Federal Republic of Germany

    Ulrich Mohr

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  1. Enrique Nogueira
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  2. Antonio Cardesa
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  3. Ulrich Mohr
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The “Journal of Cancer Research and Clinical Oncology” publishes in loose succession “Editorials” and “Guest editorials” on current and/or controversial problems in experimental and clinical oncology. These contributions represent exclusively the personal opinion of the author The Editors

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Nogueira, E., Cardesa, A. & Mohr, U. Experimental models of kidney tumors. J Cancer Res Clin Oncol 119, 190–198 (1993). https://doi.org/10.1007/BF01624430

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