Abstract
Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudoobstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. Marked neuron and nerve fibre loss were found in the myenteric plexus at postmortem. These findings show that neuronopathic Hu-associated gastrointestinal pseudo-obstruction can occur as the only paraneoplastic neurological symptom in patients with SCLC.
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Condom, E., Vidal, A., Rota, R. et al. Paraneoplastic intestinal pseudo-obstruction associated with high titres of Hu autoantibodies. Vichows Archiv A Pathol Anat 423, 507–511 (1993). https://doi.org/10.1007/BF01606543
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DOI: https://doi.org/10.1007/BF01606543