Abstract
An autopsy case of adenocarcinoma of Skene's paraurethral gland co-incident with renal cell carcinoma is described. The adenocarcinoma showed distinct prostate specific antigen and prostate specific acid phosphatase pointing to the equivalence between the male prostate and Skene's paraurethral glands and ducts. Skene's gland are the homologue of the prostate in females and tumours arising from them are immunohistochemically similar to male prostate carcinoma.
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References
Adler M (1968) Report on a primary carcinoma of the urethra as contribution to the problem of gynaecologico-urological borderline cases (in German). Zentralbl Gynakol 90:123–124
Blaustein A (1982) Pathology of the female genital tract. Springer, Berlin Heidelberg New York
Campbell M (1954) Urology. Saunders, Philadelphia
De Haan QC (1965) Paraurethral gland adenocarcinoma. Am J Obstet Gynecol 93:903–904
Egloff B (1972) Pathological anatomy of the female urethra (in German). In: Lubarsch O, Henke F, Rossle R, Uehlinger E (eds) Handbook of pathological anatomy VII (4) female reproductive organs. Springer, Berlin Heidelberg New York, pp 433–488
Epstein JI, Kuhajda FP, Liebermann PH (1986) Prostate specific acid phosphatase immunoreactivity in adenocarcinomas of the urinary bladder. Hum Pathol 17:939–944
Groben P, Karis M, Reddick RL, Siegal GP (1985) Primary transitional cell carcinoma of the female urethra with features of clear cell adenocarcinoma. Urol Int 40:294–297
Huffman JW (1948) The detailed anatomy of the paraurethral ducts in the adult human female. Am J Obst Gynecol 55:86–100
Huffman JW (1951) Clinical significance of the paraurethral ducts and glands. Arch Surg 62:615–626
Jöbsis AC (1990) Prostate. In: Filipe MI, Lake BD (eds) Histochemistry in pathology. Churchill Livingstone, Edinburgh, pp 367–372
Jöbsis AC, Vries GP, De Meier AEFH, Ploem JS (1981) The immunohistochemical detection of prostatic acid phosphatase: its possibilities and limitation in tumour histochemistry. Histochem J 13:961–973
Kamat MR, Kulkarni JN, Dhumale RG (1981) Primary carcinoma of female urethra: review of 20 cases. J Surg Oncol 16:105–109
Levine RL (1980) Urethral cancer. Cancer 45:1965–1972
Longo VJ (1982) The female prostate. Urology 20:108–109
Nadji M, Tabei SZ, Castro A, Chu M, Murphy GP, Wang MC, Morales AR (1981) Prostatic-specific-antigen. Cancer 48:1229–1232
Pollen JJ, Dreilinger A (1984) Immunohistochemical identification of prostatic acid phosphatase and prostatic specific antigen in female periurethral glands. Urology 23:303–304
Roberts TW, Melicow MM (1977) Pathology and natural history of urethral tumours in females. Urology 10:583–589
Schnitzer B (1964) Primary adenocarcinoma of the female urethra, a review and report of 2 cases. J Urol 92:35–39
Sobin LH, Hjermstad BM, Sesterhenn IA, Helwig EB (1986) Prostatic acid phosphatase activity in carcinoid tumours. Cancer 58:136–138
Svanholm H (1986) Evaluation of commercial immunoperoxidase kits for prostatic specific antigen and prostatic specific acid phosphatase. Acta Pathol Microbiol Immunol Scand [A] 94:7–12
Svanholm H, Anderson OP, Rohl H (1987) Tumour of female paraurethral duct. Immunohistochemical similarity with prostatic carcinoma. Virchows Arch [A] 411:395–398
Tepper SL, Jagirdar J, Heath D, Geller SA (1984) Homology between the female paraurethral (Skene's) gland and the prostate. Arch Pathol Lab Med 108:423–425
Zaviačič M (1987) The female prostate: non-vestigial organ of the female. A reappraisal (letter). J Sex Marit Ther 13:148–152
Zaviačič M, Zaviačičová A, Brozman M, Holomán IK, Brucháč D, Oberučová J, Kokavec M (1985) The female prostate or Skene's paraurethral glands and ducts? Reasons for returning to the original term of De Graaf (In Slovak). čs Gynek 50:372–377
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In the title and text the authors used the official term of Nomina Anatomica “paraurethral (Skene's) glands and ducts”. Nevertheless recently published data on cross-antigenicity between the male prostate and Skene's glands and the newly discovered exocrine and neuroendocrine parameters of the prostate homologue in the female, comparable with the male prostate (Zaviačič 1987), support the use of the same term — the prostate — for prostatic tissue in both sexes (Zaviačič 1987, Zaviačič et al. 1985). The designations “female prostate homologue” or “female prostate equivalent” are a compromise between terms the female prostate and Skene's paraurethral glands.
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Zaviačič, M., Šidlo, J. & Borovský, M. Prostate specific antigen and prostate specific acid phosphatase in adenocarcinoma of Skene's paraurethral glands and ducts. Vichows Archiv A Pathol Anat 423, 503–505 (1993). https://doi.org/10.1007/BF01606542
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DOI: https://doi.org/10.1007/BF01606542