Summary
We report on an alveolar rhabdomyosarcoma occurring in a 17-year-old girl. Histologically, the tumour exhibited a proliferation of small, round cells and formed alveolar structures. Immunohistochemical studies of the tumour cells showed desmin and creatine kinase MM positivity. In electron-microscopic studies, the tumour cells showed an abundance of glycogen granules, and myofilaments were recognized in the cytoplasm. Chromosome analysis revealed a translocation, t(2; 13)(q37; q14), which is thought to be common in this subtype of rhabdomyosarcoma. Conventional ultrastructural and immunohistochemical investigations and chromosome analysis thus appear to be a highly promising combination of methods for improved pathological diagnosis of alveolar rhabdomyosarcoma.
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Nojima, T., Abe, S., Yamaguchi, H. et al. A case of alveolar rhabdomyosarcoma with a chromosomal translocation, t(2; 13) (q37; q14). Vichows Archiv A Pathol Anat 417, 357–359 (1990). https://doi.org/10.1007/BF01605789
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DOI: https://doi.org/10.1007/BF01605789