Summary
Morphologically abnormal mitochondria from human glial tumours are described. For each tumour both the appearances of the mitochondria, and the subsequent mode of degeneration and formation of osmiophilic pigment is characteristic.
The significance of these observations is discussed, and it is suggested that the mode of degeneration observed reflects directly a fundamental abnormality in composition compared to normal mitochondria.
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DAAD Fellow on leave from the Department of Experimental Pathology, General Hospital, Plymouth, Devon, England.
With the support of “Deutsche Forschungsgemeinschaft” grant Gl 28/20.
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Foster, C.S., Spoerri, P.E., Glees, P. et al. The mode of mitochondrial degeneration in gliomas. Acta neurochir 43, 229–237 (1978). https://doi.org/10.1007/BF01587958
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DOI: https://doi.org/10.1007/BF01587958