Summary
The wider use of abdominal computerized axial tomography (CT) has led to the incidental discovery of increasing numbers of asymptomatic adrenal masses. The significance of these masses and the question as to their management have posed a new and important dilemma in clinical medicine. The majority of asymptomatic masses are benign and nonfunctional. The size of an adrenal mass on CT is still the most helpful finding in its evaluation. We propose that metabolically inactive lesions <3.5 cm in diameter on CT be followed with serial scans at 2, 6, and 18 months. After hormonal assessment, surgery should be carried out on lesions >6 cm, because there is a high probability for malignancy. For tumors 3.0–6.0 cm in diameter, management should be individualized. Under certain circumstances, especially in older and poor-risk patients, a conservative approach with more frequently obtained CT scans (6-week intervals) may be recommended. At the present time, magnetic resonance imaging (MRI) techniques cannot reliably distinguish benign from malignant adrenal masses and should be considered investigational in this setting, pending results of larger studies to determine its true sensitivity and specificity.
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References
Abrams HL, Siegelman SS, Adams DF (1982) Computed tomography versus ultrasound of the adrenal gland: a prospective study. Radiology 143:121–128
Belldegrun A, Richie JP (1986) Tumors of the adrenal gland. In: Graham SD (eds) Urologic oncology. Raven, New York, pp 243–266
Belldegrun A, Hussain S, Seltzer SE, Laughlin KR, Gittes RF, Richie JP (1984) Computed tomoraphy in the diagnosis of primary tumors of the adrenal gland: a clinical pathological correlation (abstract). J Urol 131:176
Belldegrun A, Hussain S, Seltzer SE, Laughlin KR, Gittes RF, Richie JP (1986) Incidentally discovered mass of the adrenal gland. Surg Gynecol Obstet 163:203–208
Bernardino ME, Walther MM, (1985) CT-guided adrenal biopsy: accuracy, safety and indications. AJR 144:67–69
Bradley EL III (1975) Primary adjunctive therapy in carcinoma of the adrenal cortex. Surg Gynecol Obstet 141:507–511
Casola G, Nicolet V (1986) Unsuspected pheochromocytoma: risk of blood pressure alterations during percutaneous adrenal biopsy. Radiology 159:733–735
Cedermark BJ, Ohlsen H (1981) Computed tomography in the diagnosis of metastases of the adrenal glands. Surg Gynecol Obstet 152:13–16
Chang A, Glazer HS (1987) Adrenal gland: MR imaging. Radiology 163:123–128
Copeland PM (1983) The incidentally discovered adrenal mass. Ann Intern Med 98:940–945
Davidson AJ, Hartman DS (1987) Imaging strategies for tumors of the kidney, adrenal gland, and retroperitoneum. Am Cancer J 37:151–164
Doppmand JL, Reinig JW (1987) Differentiation of adrenal masses by magnetic resonance imaging. Surgery 102:1018–1026
Dunnick NR, Doppman JL (1982) Localization of functional adrenal tumors by computed tomography and venous sampling. Radiology 142:429–433
Dunnick NR (1982) CT appearance of adrenal cortical carcinoma. J Comput Assist Tomogr 6:978–982
Falke THM, Strake L (1986) MR imaging of the adrenals: correlation with computed tomography. J Comput Assist Tomogr 10:242–253
Geelhoed GW, Druy EM (1982) Management of the adrenal “incidentaloma”. Surgery 92:866–874
Glazer HS, Weyman PJ (1982) Nonfunctioning adrenal masses: incidental discovery on computed tomography. Am J Roentgenol 139:81–85
Hamper UM, Fishman EK (1987) Primary adrenocortical carcinoma: sonographic evaluation with clinical and pathologic correlation in 26 patients. AJR 148:915–919
Hedeland H, Ostbert G, Hokfelt B (1968) On the prevalence of adrenocortical adenomas in an autopsy material in relation to hypertension and diabetes. Acta Med Scand 184:211–214
Hussain S, Belldegrun A, (1985) Differentiation of malignant from benign adrenal masses: predictive indices on computed tomography. AJR 144:61–65
Hussain S, Belldegrun A (1986) CT diagnosis of adrenal abnormalities in patients with primary non-adrenal malignancies. Eur J Radiol 6:127–131
Karstaedt N, Sagel SS (1978) Computed tomography of the adrenal gland. Radiology 129:723–730
Katz RL, Shirkohoda A (1985) Diagnostic approach to incidental adrenal nodules in the cancer patient. Cancer 55:1995–2000
Korobkin M, White EA (1979) Computed tomography in the diagnosis of adrenal disease. Am J Roentgenol 132:231–238
Koss LG (1984) The adrenal. In. Koss LG, Woyke S, Olszewski W (ed) Aspiration biopsy: cytologic interpretation and histologic bases. Igaku-Shoin, New York; pp 408–410
McClelland RN (1988) Overview of papers on the adrenal gland. In: Select Reading Gen Surg 15:1–44
Mitnick JS, Bosniak MA (1983) Nonfunctionaing adrenal adenomas discovered incidentally on computed tomography. Radiology 148:495–499
Moulton JS, Moulton JS (1988) CT of the adrenal glands. Semin Roentgenol 23:288–303
Prinz RA, Brooks MH (1982) Incidental asymptomatic adrenal masses detected by computed tomographic scanning: Is operation required? JAMA 248:701–704
Reynes CJ, Churchill R (1979) Computed tomography of adrenal glands. Radiol Clin North Am 17:91–104
Reinig JW, Doppman JL (1986) Adrenal masses differentiated by MR. Radiology 158:81–84
Reinig JW, Doppman JL (1986) MRI of indeterminate adrenal masses. AJR 147:493–496
Tang CK, Gray GF (1975) Adrenocortical neoplasms. Urology 5:691–695
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Belldegrun, A., deKernion, J.B. What to do about the incidentally found adrenal mass. World J Urol 7, 117–120 (1989). https://doi.org/10.1007/BF01576896
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DOI: https://doi.org/10.1007/BF01576896