Abstract
TheIf-1 alleles of many inbred strains, some of common parentage with either BALB/c Gif or C57BL/Lac, were determined. Of the 23 inbred lines examined, all were eitherIf-1 h orIf-1 l, except the C57BR/cdJ strain, which gave intermediate results; the latter will have to be explored more thoroughly before the existence of a third allele can be established. Survey of the 23 lines showed no correlation betweenH-2 haplotypes andIf-1 alleles. The absence of linkage betweenH-2 andIf-1 was confirmed by typing (BALB/c×C57BL)F1×C57BL backcross progeny for bothH-2 andIf-1. The fact that some high and some low producers were of sameH-2 type made it possible to study the production of interferon in radiation chimeras. Mice of a low-producer strain, C3H/Lac (If-1 l, were lethally irradiated and their hemopoietic function restored by grafting bone marrow from eitherIf-1 l orIf-1 h mice, all donors of the sameH-2 haplotype as that of the recipients (H-2 k. NDV-induced serum interferon production was measured 31 days after irradiation and restoration. The production of interferon in all mice restored with marrow fromIf-1 l donors was equal or lower than that of syngeneic chimeras (alsoIf-1 l). In contrast, titers of interferon in all four groups restored withIf-1 h marrow were higher than those of control chimeras, three being higher than titers in unirradiatedIf-1 l controls. These data indicate that theIf-1 locus is expressed through cells derived from hemopoietic stem cells, possibly the interferon-producing cells themselves.
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De Maeyer, E., Jullien, P., De Maeyer-Guignard, J. et al. Effect of mouse genotype on interferon production II. Distribution ofIf-1 alleles among inbred strains and transfer of phenotype by grafting bone marrow cells. Immunogenetics 2, 151–160 (1975). https://doi.org/10.1007/BF01572283
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DOI: https://doi.org/10.1007/BF01572283