Abstract
In early experiments, rejection of strain A skin allografts by (B6×A)→B6 radiation chimeras indicated that mouse epidermal cells possess a distinctive transplantation alloantigen that is absent from marrow and lymphoid cells. Current studies reveal the existence of at least two such skin-specific antigens, determined by two segregating genetic loci.
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Bennett, D.: The T-locus of the mouse.Cell 6:441–454, 1975
Bennett, D., Boyse, E.A., and Old, L.J.: Cell surface immunogenetics in the study of morphogenesis.In L.G. Silvestri (ed.):Cell Interactions, pp. 247–263. North Holland Publishing Co., Amsterdam, 1972
Billingham, R.E.: Free skin grafting in mammals.In R.E. Billingham and W.K. Silvers (eds.):Transplantation of Tissues and Cells, pp. 1–26. The Wistar Institute Press, Philadelphia, 1961
Billingham, R.E.: The induction of tolerance of homologous tissue grafts.In R.E. Billingham and W.K. Silvers (eds.):Transplantation of Tissues and Cells, pp. 87–106. The Wistar Institute Press, Philadelphia, 1961
Boyse, E.A. and Old, L.J.: An invitation to surveillance.In R.T. Smith and M. Landy (eds.):Immune Surveillance, pp. 5–30. Academic Press, New York, 1970
Boyse, E.A., Lance, E.M., Carswell, E.A., Cooper, S., and Old, L.J.: Rejection of skin allografts by radiation chimaeras: selective gene action in the specification of cell surface structure.Nature 227:901–903, 1970
Boyse, E.A., Old, L.J., and Scheid, M.: Selective gene action in the specification of cell surface structure.Am J. Pathol. 65:439–450, 1971
Gorer, P.A. and Mikulska, Z.B.: Antibody response to tumor inoculation. Improved method of antibody detection.Cancer Res. 14:651–655, 1954
Lance, E.M., Boyse, E.A., Cooper, S., and Carswell, E.A.: Rejection of skin allografts by irradiation chimeras: evidence for a skin-specific transplantation barrier.Transplant Proc. 3:864–868, 1971
Raff, M.C., Nase, S., and Mitchison, N.A.: Mouse specific bone marrow-derived lymphocyte antigens as a marker for thymus-independent lymphocytes.Nature 230:50–51, 1971
Scheid, M., Boyse, E.A., Carswell, E.A., and Old, L.J.: Serologically demonstrable alloantigens of mouse epidermal cells.J. Exp. Med. 135:938–955, 1972
Sena, J., Wachtel, S.S., and Murphy, G.: A comparison of the survival of H-Y incompatible ear, tail and body skin grafts.Transplantation 21:412–416, 1976
Shigeno, N., Arpels, C., Hämmerling, U., Boyse, E.A., and Old, L.J.: Preparation of lymphocyte-specific antibody from anti-lymphocyte serum.Lancet 2:320–323, 1968
Takahashi, T., Old, L.J., Hsu, C.J., and Boyse, E.A.: A new differentiation antigen of plasma cells.Eur. J. Immunol. 1:478–482, 1971
Takahashi, T., Old, L.J., McIntire, K.R., and Boyse, E.A.: Immunoglobulin and other surface antigens of cells of the immune system.J. Exp. Med. 134:815–832, 1971b
Wachtel, S.S. and Silvers, W.K.: Skin homografts: tolerogenic versus immunogenic influences in mice.J. Exp. Med. 133:921–937, 1971
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Wachtel, S.S., Thaler, H.T. & Boyse, E.A. A second system of alloantigens expressed selectively on epidermal cells of the mouse. Immunogenetics 5, 17–23 (1977). https://doi.org/10.1007/BF01570459
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DOI: https://doi.org/10.1007/BF01570459