Abstract
Recent studies suggest that the gene locus controlling the fate of tumors induced by Rous sarcoma virus (RSV) is linked to theB histocompatibility complex. Birds carrying the dominant allele regress the tumor; homozygous recessives being unable to do so, develop large tumors and die. These are called progressors.
The Bryan strain of RSV was inoculated into 220 6 week old Leghorns homozygous forB 1 B 1,B 2 B 2, orB 19 B 19 of which the percentages of progressors were 79, 22 and 56, respectively. The balance of each were regressors and survived.
TheB 1 B 1 test birds were derived from special matings, i.e., high and low immune responders to the amino acid polymer, GAT. Of 67 tests progeny of theB 1 B 1 GAT-low mating, 63 or 94% proved to be progressors, and 6% were regressors. Of 84 test progeny of theB 1 B 1 GAT-high matings, 67% were progressors, and 33% were regressors. The difference between the high and low GAT responders is highly significant and indicates that the locus controlling the fate of RSV-induced tumors is closely linked to the locus controlling immune response to GAT. The latter maps within theIr region of theB histocompatibility complex.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Collins, W. M., Briles, W. E., Zsigray, R. M., Dunlop, W. R., Corbett, A. C., Clark, K. K., Marks, J. L., and McGrail, T. P.: TheB locus (MHC) in the chickens: Association with the fate of RSV-induced tumors.Immunogenetics 5: 333–343, 1977
Crittenden, L. B.: Two levels of genetic resistance to lymphoid leukosis.Avian Dis. 19:281–292. 1975
Crittenden, L. B., Johnson, L. W., and Okazaki, W.: Histocompatibility and erythrocyte antigen variability within highly inbred lines of White Leghorns.Transplantation 2:362–374, 1964
Falconer, D. S.:Introduction to Quantitative Genetics. Eighth printing. The Ronald Press Company, New York, 1960
Gyles, N. R., Stewart, B. R., and Brown, C. J.: Mechanisms of genetic resistance in the chicken to Rous Sarcoma virus.Poult. Sci. 47:430–450, 1968
Nordskog, A. W., Rishell, W. A., and Briggs, D. M.: Influence of B blood groups on adult mortality and egg production in the White Leghorn chicken.Genetics 75:181–189, 1973.
Nordskog, A. W., Pevzner, I. Y., Trowbridge, C. L., and Benedict, A. A.: Immune response and adult mortality associated with the B locus in chicken.In A. A. Benedict (ed.):Avian Immunology, pp. 245–256, Plenum Press, New York, 1977
Pevzner, I. Y., Trowbridge, C. L., and Nordskog, A. W.: Selection for high and low antibody response to Salmonella pullorum in Chickens.Genetics 86: 48–49, 1977
Pevzner, I. Y., Trowbridge, C. L., and Nordskog, A. W.: Recombination between genes coding for — immune response and the serologically determined antigens in the chickenB system.Immunogenetics 7:25–33, 1978
Schierman, L. W., Watanabe, D. H., and McBride, R. A.: Genetic control of Rous Sarcoma regression in chickens: Linkage with the major histocompatibility complex.Immunogenetics 5:325–332, 1977
Waters, N. F. and Burmester, B. R.: Mode of inheritance of resistance to Rous Sarcoma virus in chickens.J. Natl. Cancer Inst. 27:655–661, 1961
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gebriel, G.M., Pevzner, I.Y. & Nordskog, A.W. Genetic linkage between immune response to GAT and the fate of RSV-induced tumors in chickens. Immunogenetics 9, 327–334 (1979). https://doi.org/10.1007/BF01570428
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01570428