Summary
A short review about the biosensor research activities for bioprocess monitoring in the F.R.G. after its reunification is given. The principles of biosensor applications are presented. In situ sensors and sensors based on the principles of flow injection analysis are studied. Some applications of a four-channel enzyme thermistor, bio-field effect transistors, and immunoanalysis systems for real process monitoring are presented.
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Scheller, F. and F. Schubert. 1991. Biosensors, Elsevier Sci. Publ., Amsterdam, in press.
Flow Injection analysis (FIA) Based on Enzymes or Antibodies (R.D. Schmid, ed.), GBF-Monographs, Vol. 14, VCH-Weinheim, 1990.
Biosensors: Fundamentals, Technologies and Applications (R.D. Schmid, F. Scheller, eds.), GBF, Monographs, VCH-Weinheim, in press.
Gründig, B. and C. Krabisch. 1989. Electron mediator-modified electrode for the determination of glucose in fermentation media. Anal. Chim. Acta 222: 75–81.
Brand, U., L. Brandes, V. Koch, T. Kullik, B. Reinhardt, F. Rüther, T. Scheper, K. Schügerl, S. Wang, X. Wu, R. Ferretti, S. Prasad and D. Wilhelm. 1991. Monitoring and control of biotechnological production processes by Bio-FET-FIA-sensors. Appl. Microbiol. Biotechnol. 36: 167–172.
Brand, U., B. Reinhardt, F. Rüther, T. Scheper and K. Schügerl. 1990. Bio-field-effect transistors as detectors in flow-injection analysis. Anal. Chim. Acta 238: 201–210.
Bradley, J. and R.D. Schmid. 1992. Optimization of a biosensor for in situ fermentation monitoring of glucose concentration, Biosens. Bioelectron., in press.
Bradley, J., A.P.F. Turner and R.D. Schmid. 1989. An in situ fermenter probe for bakers yeast propagation monitoring, In: Biosensors—Applications in medicine, environmental protection and process control, (R.D. Schmid and F. Scheller, eds.), GBF Monographs, Vol. 13, Verlag Chemie, Weinheim, 85–89.
Filippini, C., B. Sonnleitner, A. Fiechter, J. Bradley and R.D. Schmid. 1991. On-line determination of glucose in biotechnological processes—comparison between FIA and an in situ enzyme electrode. J. Biotechnol. 18: 153–162.
Ogbomo, I., R. Kittstein-Eberle, U. Englbrecht, U. Prinzing, J. Danzer and H.L. Schmidt. 1991. Flow-injection systems for the determination of oxidoreductase substrates: applications in food quality control and process monitoring. Anal. Chim. Acta, in press.
Kittstein-Eberle, R., I. Ogbomo and H.-L. Schmidt. 1989. Biosensing devices for the semi-automated control of dehydrogenase substrates in fermentations, Biosensors 4: 75–85.
Wehnert, G., A. Sauerbrei, T. Bayer, T. Scheper, K. Schügerl and T. Herold. 1987. Application of an enzyme thermistor for the determination of glucose in complex fermentation media. Anal. Chim. Acta 200: 73–84.
Scheper, T., K.D. Anders, R. Freitag, H.G. Hundeck, W. Müller, C. Schelp, A.F. Bückmann and K.F. Reardon. 1989. Biosensor systems for process control in biotechnology, GBF-Monographs (R.D. Schmid, F. Scheller, eds.), Vol. 13: 253–263.
Scheper, T., W. Brandes, C. Grau, H.G. Hundeck, B. Reinhardt, F. Rüther, F. Plötz, K. Schügerl, K.H. Schneider, F. Giffhorn, B. Rehr and H. Sahm. 1991. Applications of biosensor systems for bioprocess monitoring. Anal. Chim. Acta 249: 25–34.
Schügerl, K., A. Lübbert and T. Scheper. 1990. Online process analysis in bioreactors. Int. Chem. Eng. 30: 433–451.
Spohn, U., R. Eberhardt, B. Joksch, R. Wichmann, C. Wandrey and H. Voß. 1990. Enzymatic multi-channel-FIA methods for online fermentation monitoring and control. In: Flow injection analysis (FIA) based on enzymes or antibodies (R.D. Schmid, ed.), GBF-Monographs, Vol. 14, VCH-Weinheim, 52–62.
Hundeck, H.G., A. Sauerbrei, U. Hübner, T. Scheper and K. Schügerl. 1990. Four-channel enzyme thermistor system for process monitoring and control in biotechnology. Anal. Chim. Acta 238: 211–220.
Huang, Y.L., S.Y. Li, B.A.A. Dremel, U. Bilitewski and R.D. Schmid. 1991. On-line determination of glucose concentration throughout animal cell cultures based on chemiluminescent detection of hydrogen peroxide coupled with flow-injection analysis. J. Biotechnol. 18: 161.
Dremel, B.A.A., S.Y. Li and R.D. Schmid. 1991. On-line determination of glucose and lactate concentration in animal cell culture based on fibre optic detection of oxygen in flow-injection analysis. Biosen. Bioelectron., in press.
Trott-Kriegskorte, G., R. Renneberg, M. Pawlowa, F. Schubert, J. Hammer, V. Jäger, R. Wagner, R.D. Schmid and F. Scheller. 1989. Enzyme sensors for process control of cell cultures. In: Biosensors—Applications in medicine, environmental protection and process control, (R.D. Schmid and F. Scheller, eds.), GBF Monographs, Vol. 13, Verlag Chemie, Weinheim, 67–83.
Dremel, B.A.A., W. Wang and R.D. Schmid. 1990. On-line lactic acid determination of a kefir fermentation based on a fibre optic lactic acid biosensor and flow-injection analysis, Anal. Chim. Acta 234: 107–123.
Ogbomo, I., R. Kittstein-Eberle, U. Prinzing and H.L. Schmidt. 1990. FIA-systems for the determination of maltose, lactate and volatile substances in beer, wine and fermentation broths. In: Flow injection analysis (FIA) based on enzymes or antibodies (R.D. Schmid, ed.), GBF-Monographs, Vol. 14, VCH-Weinheim, 209–216.
Künnecke, W. and R.D. Schmid. 1989. Determination of ethanol for process and quality control using flow injection analysis, In: Biosensors—Applications in medicine, environmental protection and process control, (R.D. Schmid and F. Scheller, eds.), GBF Monographs, Vol. 13, VCH-Weinheim, 303–315.
Schelp, C., T. Scheper and A.F. Bückmann. 1989. The use of fluorescence sensors as optical biosensors. In: Biosensors—Applications in medicine, environmental protection and process control, (R.D. Schmid and F. Scheller, eds.), GBF Monographs, Vol. 13, VCH-Weinheim, 263–269.
Joksch, B., R. Eberhardt, U. Spohn, D. Weuster and C. Wandrey. 1990. Ethanol fermentation monitoring by enzymatic multichannel-FIA, In: Flow injection analysis (FIA) based on enzymes or antibodies (R.D. Schmid, ed.), GBF-Monographs, Vol. 14, VCH-Weinheim, 64–72.
Stöcklein, W. and R.D. Schmid. (1990). Rapid determination of microorganisms using a flow-injection system. Anal. Chim. Acta 234: 247–254.
Fenge, C., E. Fraune, R. Freitag, T. Scheper and K. Schügerl. 1991. On-line monitoring of monoclonal antibody formation in high density perfusion culture using FIA. Cytotechnol. 6: 55–63.
Freitag, R., T. Scheper, A. Spreinat and G. Antranikian. 1991. On-line monitoring of pullulanase production during continuous culture ofClostridium thermosulfurogenes. Appl. Microbiol. Biotechnol. 35: 471–547.
Freitag, R., T. Scheper and K. Schügerl. 1991. Development of a turbidimetric immunoassay for on-line monitoring proteins in cultivation processes. Enzyme Microb. Techn., in press.
Degelau, A., R. Freitag, F. Linz, C. Middendorf, T. Scheper, T. Bley, S. Müller, P. Stoll and K.F. Reardon. 1991. Immuno-and flow cytometric analytical methods for biotechnological research and process monitoring. J. Biotechnol., in press.
Danielsson, B. and K. Mosbach. 1987. Theory and application of calorimetric sensors. In: Biosensors: Fundamentals and Applications. (A.P.F. Turner, I. Karube, G.S. Wilson, eds.) Oxford University Press, Oxford, 575–595.
Mosbach, K. 1991. Thermal biosensors, Biosens. Bioelectron. 6: 179–182.
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Scheper, T. Biosensors for process monitoring. Journal of Industrial Microbiology 9, 163–172 (1992). https://doi.org/10.1007/BF01569620
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DOI: https://doi.org/10.1007/BF01569620