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Phylogenetic distribution of components of the overflow pathway tol-phenylalanine within the enteric lineage of bacteria

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Abstract

The enteric lineage of prokaryotes (traditional enteric bacteria,Aeromonas, andAlteromonas) encompasses closely related genera that share many common character states of aromatic amino acid biosynthesis. For example, they uniformly employ the tightly regulated bifunctional P-protein (chorismate mutase: prephenate dehydratase) to forml-phenylalanine via phenylpyruvate. A second, unregulated pathway to phenylalanine, originally termed the overflow pathway inPseudomonas aeruginosa, consists of a monofunctional chorismate mutase (CM-F) and a cyclohexadienyl dehydratase. The evolution of the overflow pathway has been dynamic in the enteric lineage.Serratia marcescens, Erwinia herbicola, Erwinia amylovora, and several otherErwinia species possess an intact pathway.Salmonella, Klebsiella, andErwinia carotovora possess an incomplete overflow pathway, whileEscherichia, Proteus, Aeromonas, andAlteromonas lack it altogether.

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  1. Department of Microbiology and Cell Science, University of Florida, 1059 McCarty Hall, IFAS, 32611, Gainesville, FL, USA

    Suhail Ahmad &  Roy A. Jensen

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  1. Suhail Ahmad
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Ahmad, S., Jensen, R.A. Phylogenetic distribution of components of the overflow pathway tol-phenylalanine within the enteric lineage of bacteria. Current Microbiology 16, 295–302 (1988). https://doi.org/10.1007/BF01568535

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