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Resistance to HSV-1 in the mouse is governed by two major, independently segregating, non-H-2 loci

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Abstract

Earlier studies showed that genetic resistance of adult, inbred strains of mice to Herpes Simplex Virus-type 1 (HSV-1) is a dominant genetic trait. The present studies were undertaken to determine the number of genetic loci involved and whether they were found within the major histocompatibility complex,H-2, of the mouse. Challenge with HSV-1 of progeny of mice backcrossed to moderately susceptible BALB/c mice, of progeny of mice backcrossed to very susceptible A/J strain mice, and of progeny of the F-2 cross using (C57BL/6 × A/J)F1 mice indicated that two major loci were responsible for resistance. The backcrosses to BALB/c mice suggested that additional genes on this background enhanced resistance, while further backcrosses with the A/J mice indicated that other genes on the A/J background (or the lack thereof) reduced resistance. Studies with congenic mice showed that genes within theH-2 did not influence resistance or susceptibility.

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Authors and Affiliations

  1. Laboratory of Herpesvirus Infections, Sloan-Kettering Institute for Cancer Research, 425 East 68th Street, 10021, New York, New York

    Carlos Lopez

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  1. Carlos Lopez
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Lopez, C. Resistance to HSV-1 in the mouse is governed by two major, independently segregating, non-H-2 loci. Immunogenetics 11, 87–92 (1980). https://doi.org/10.1007/BF01567772

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  • DOI: https://doi.org/10.1007/BF01567772

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