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Microaneurysms in diabetes mellitus

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Riassunto

Vengono esaminate in dettaglio le caratteristiche strutturali dei microaneurismi retinici, glomerulari e congiuntivali, nonché le relative somiglianze. I fattori predisponenti vengono passati in rassegna. L'associazione di ipertrigliceridemia con fattori reologici locali, quali la stasi venulare o l'ischemia capillare, porta spesso alla formazione di microaneurismi. Questa concomitanza di fattori è presente in certa misura nell'ipertensione, ma più particolarmente nel diabete.

Résumé

One examine en détail les caractéristiques structurales des micro-anévrismes de la rétine, des glomérules et des conjonctives, ainsi que les analogies relatives. On passe en revue les facteurs determinants. L'association de hypertriglycéridémie avec des facteurs rhéologiques locaux, telles que la stase des veines ou l'ischémie capillaire, comporte souvent la formation de micro-anévrismes. Cette coincidence de facteurs est présente, dans une certaine mesure, dans l'hypertension, notamment dans le diabète.

Resumen

Se examinan detalladamente las características estructurales de los microaneurismas retínicos, glomerulares y conjuntivales, así como también sus correspondientes semejanzas y se enumeran los factores capaces de determinar una predisposición a esas manifestaciones. La asociación de la hipergliceridemia con factores reológicos locales, tales como la estasis venular o la isquemia capilar, dteermina a menudo la formación de microaneurismas. Esa concomitancia de factores se da en cierta medida en la hipertensión, pero más particularmente en la diabetes.

Zusammenfassung

Die strukturellen Einzelheiten von Netzhaut- Glomerulus- und Bindehaut-aneurysmen wurden untersucht und die Ähnlichkeiten gesucht. Auch prädisponierende Faktoren werden besprochen. Das Zusammentreffen einer Hypertriglyzeridämie mit lokalen Druckfaktoren, wie z.B. Stase in den kleinen Venen und kapilläre Ischämie, führt häufig zur Bildung von Mikroaneurysmen. Eine solche Faktorenkombination findet sich in einem gewissen Ausmass beim Hochdruck, aber vor allem bei Diabetes.

Summary

The structural characteristics of and similarities between retinal, glomerular and conjunctival microaneurysms are detailed. Predisposing factors are reviewed. A combination of hypertriglyceridemia and local rheological factors such as venular stasis or capillary ischaemia frequently leads to the formation of microaneurysms. This combination of factors pertains to some extent in hypertension but more particularly in diabetes.

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Authors and Affiliations

  1. General Hospital Chester Road, Sunderland, Co. Durham, Great Britain

    Bernard I. Chazan

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  1. Bernard I. Chazan
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Additional information

This work is partly based on a thesis for M. D. submitted by the author to Glasgow University.

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Chazan, B.I. Microaneurysms in diabetes mellitus. Acta diabet. lat 9, 337–349 (1972). https://doi.org/10.1007/BF01564557

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