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Kidney transplantation between congenic versus standard inbred strains of rats: I The significance ofH-1 and non-H-1 gene differences

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Abstract

Concepts of “antigenic strength” in organ transplantation have been evaluated in relation to orthotopic kidney allografts inH-1 congenic strains of rats. Untreated recipients reject fully allogeneic kidneys possessing singleH-1 differences as acutely as kidneys displaying multiple histocompatibility differences. Heterozygozity for H-1 specificities as well as for H-1 plus non-H-1 specificities (semiallogeneic kidneys) favors long term survival (autoenhancement), especially when the specific immune response genes of the recipient lead to reduced reactivity. In active enhancement, the transplantedH-1 congenic kidneys, devoid of additional weak antigens, retain prolonged functional integrity. Weak non-H-1 antigens substantially influence the successful establishment of specific enhancement in an adverse way, either as additive immunogens or as target sites for the effector arm of the rejection response.

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Authors and Affiliations

  1. I. Medizinische Klinik, Immunbiologisches Labor, und Sonderforschungsbereich 37 der Universität 8, Ziemssenstr. 1, München 2, Germany

    Gunther H. Thoenes, Gela Urban & Inge Doering

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  1. Gunther H. Thoenes
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  2. Gela Urban
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  3. Inge Doering
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Thoenes, G.H., Urban, G. & Doering, I. Kidney transplantation between congenic versus standard inbred strains of rats: I The significance ofH-1 and non-H-1 gene differences. Immunogenetics 1, 239–253 (1974). https://doi.org/10.1007/BF01564065

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  • DOI: https://doi.org/10.1007/BF01564065

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