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IgM allotypes in rabbit

I.a Locus associated allotypic determinants

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Abstract

Six new IgM allotypes-Msl6, Msl7, Ms21, Ms23, Ms24, and Ms25-have been detected. Genetics of these markers has been studied by radioimmunoassay, since immunodiffusion in gel was not sensitive enough to detect low concentrations of IgM in the serum. All the six markers are closely linked to thea locus; Ms 16 and Ms 17 behave as alleles and can be found associated with any of the three majora locus markers. In contrast to these findings, the other four allotypes are always associated with haplotypes carrying a particular a-locus marker associated with a particular μ chain allotype (Ms 16 or Ms 17).

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Naessens, J., Hamers-Casterman, C., Hamers, R. et al. IgM allotypes in rabbit. Immunogenetics 6, 17–27 (1978). https://doi.org/10.1007/BF01563893

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