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An introduction to the neurobiology of oro-facial growth

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Summary

Neurotrophism describes a non-membrane conductive activity by which interactions occur between neurons and other cells which initiate or control molecular modifications in other cells. Neuro-epithelial, neuro-muscular, and neuro-visceral trophism is defined and discussed in some detail. Some emphasis is given to data indicating possible neurotrophic control of genetic activity of muscle. It is considered that oro-facial growth may be conceived of as a homeostatically controlled series of processes in which the neural center regulates the peripheral tissues and the periphery, in turn, regulates the center. While this neurobiological hypothesis may stimulate future research, we must clearly understand that we must also inquire as to the means by which neurotrophism is integrated with those other processes involved in growth regulation.

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Literature cited

  • Beagrie, G. S. (1970). The in-vivo effects of H3-thymidine on the mitosis in oral epithelium of the mouse.-Arch. Oral Biol.,15, p. 205–211.

    Google Scholar 

  • Berry, D. C. (1969). Dentures, partial oral awareness, and the design of partial dentures.-Proc. Roy. Soc. Med.,62, p. 608–609.

    Google Scholar 

  • Blair, G. A. S. &J. Scott (1969). The treatment of functional disorders of the masticatory system by the use of stainless steel plates.-Dent. Practit.,19, p. 165–168.

    Google Scholar 

  • Bornstein, M. B., M. Iwanami, G. M. Lehrer, &L. Breitbart (1968). Observations on the appearance of neuromuscular relationships in cultured mouse tissues.-Zeit. für Zellforsch.,92, p. 197–206.

    Google Scholar 

  • Bosma, J. F. (1967). Symposium on Oral Sensation and Perception.-In: J. F. Bosnia (ed.).Oral Sensation and Perception, C. C. Thomas, Springfield.

    Google Scholar 

  • — (1970). Second Symposium on Oral Sensation and Perception.-In: J. F. Bosma (ed.).Oral Sensation and Perception, C. C. Thomas, Springfield.

    Google Scholar 

  • Bosma, J. F., R. C. Grosman, &J. F. Kavanagh (1967). A syndrome of impairment of oral perception.-In: J. F. Bosma (ed.).Symposium on Oral Sensation and Perception. C. C. Thomas, Springfield.

    Google Scholar 

  • Buller, A. J., W. F. H. M. Mommaerts, &K. Seraydarian (1969). Enzymic properties of myosin in fast and slow twitch muscles of the cat following crossinnervation.-J. Physiol.,203, p. 581–597.

    Google Scholar 

  • Bullough, W. S. (1962). The control of mitotic activity in adult mammalian tissues.-Biol. Rev.,37, p. 307–342.

    Google Scholar 

  • Bullough, W. S., &E. B. Laurence (1960). The control of mitotic activity in mouse skin.-Exp. Cell Res.,21, p. 394–405.

    Google Scholar 

  • Chou, S. M. (1970). Axoplasmic flow rates on the monkey optic system.-Neurology20, p. 607–612.

    Google Scholar 

  • Close, R. (1969). Dynamic properties of fast and slow skeletal muscles of the rat after nerve cross-union.-J. Physiol.,204, p. 331–346.

    Google Scholar 

  • Cox, P. G. (1969). Some aspects of tail regeneration in the lizard,Anolis carolinensis. II. The role of the peripheral nerves.-J. exp. Zool.,171, p. 151–160.

    Google Scholar 

  • Dancis, J., &A. A. Smith (1966). Familial dysautonomia.-New Engl.J. Med.,274, p. 207–209.

    Google Scholar 

  • Deck, J. D., &C. B. Futch (1969). The effects of infused materials upon the regeneration of newt limbs. I Blastemal extracts in denervated limb stumps.-Developm. Biol.,20, p. 332–348.

    Google Scholar 

  • Dickler, E., P. D. Toto, &A. W. Gargino (1969) Cell kinetics of the oral epithelium of adrenalectomized and of hypophysectomized mice.-J. Periodont.,40, p. 336–349.

    Google Scholar 

  • Dixon, A. D. (1962). The position, incidence and origin of sensory nerve terminations in oral mucous membrane.-Arch. Oral Biol.,7, p. 39–48.

    Google Scholar 

  • Dresden, Marc H. (1969). Denervation effects on newt limb regeneration: DNA, RNA, and protein synthesis.-Develop. Biol.,19, p. 311–320.

    Google Scholar 

  • Dubowitz, V. (1968). Further studies on fibre types in skeletal muscle.-In:Research in Muscular Dystrophy. (The Proceedings of the Fourth Symposium on Current Research in Muscular Dystrophy held at The National Hospital, Queen Square, London, W. C. i). Pitman Medical Pub. Co., Ltd.

    Google Scholar 

  • Elgjo, K. (1969). Epidermal cell proliferation during the first 24 hrs. after injection of an aqueous skin extract (Chalone).-Virchows Arch.,4, p. 119–125.

    Google Scholar 

  • Fawcus, R. (1968). Dental problems in speech pathology.-Roy. Soc. Med. Proc.,61, p. 619–622.

    Google Scholar 

  • Fenton, E. L., C. B. Mann, &D. C. Edwards (1970). Studies on the isolation of epithelial growth factor from fractions of mouse salivary-gland extracts.-Biochem. J.,118, p. 32–33.

    Google Scholar 

  • Fex, S. (1969). “Trophic” influence of implanted fast nerve on innervated muscle.-Physiol. Bohemoslov.,18, p. 205–208.

    Google Scholar 

  • Fex, S., &B. Sonesson (1970). Histochemical observations after implantation of a “fast” nerve into an innervated mammalian “slow” skeletal muscle.-Acta Anat.,77, p. 1–10.

    Google Scholar 

  • Fex, S., &S. Thesleff (1967). The time required for innervation of denervated muscles by nerve implants.-Life Sci.,6, p. 635–639.

    Google Scholar 

  • Flaxman, B. A., P. F. Maderson, G. Szabo, &S. I. Roth (1968). Control of cell differentiation in lizard epidermis in vitro.-Developm. Biol.,28, p. 354–374.

    Google Scholar 

  • Frank, R. M., &P. Karli (1962). Destruction electrolytique des noyaux centraux du trijumea chez le rat et ses repercussions au niveau de la region faciale.-Arch. Oral Biol.,7, p. 381–389.

    Google Scholar 

  • Gabella, G. (1969). Taste buds and adrenergic fibres.-J. Neurol. Sci.,9, p. 237–242.

    Google Scholar 

  • Gaunt, W. A. (1965). Some observations upon the histology of the oral mucosa of the albino mouse.-Acta Anat.,60, p. 516–530.

    Google Scholar 

  • Giacometti, L., &P. F. Parakkal (1969). Skin transplantation: Orientation of epithelial cells by the basement membrane.-Nature,223, p. 514–515.

    Google Scholar 

  • Goss, R. J. (1969).Principles of Regeneration.-Academic Press, N.Y.

    Google Scholar 

  • Guth, L. (1963). Histological changes following partial denervation of the circumvallate papilla of the rat.-Exp. Neurol.,8, p. 336–349.

    Google Scholar 

  • — (1969). “Trophic” effects of vertebrate neurons.-Neurosci. Res. Prog. Bull.,7, p. 55–70.

    Google Scholar 

  • Guth, L., P. K. Watson, &W. C. Brown (1968). Effects of cross-reinnervation on some chemical properties of red and white muscles of rat and cat.-Exp. Neurol.,20, p. 52–69.

    Google Scholar 

  • Gutmann, E. (1963). Evidence for the trophic function of the nerve cell in neuromuscular relations.-In:E. Gutmann &P. Hnik (eds.).The Effect of Use and Disuse on Neuromuscular Functions. Elsevier, Amsterdam.

    Google Scholar 

  • — (1964). Neurotrophic relations in the regeneration process.-In:M. Singer &J. P. Schade (eds.).Mechanisms of Neural Regeneration (Progress in Brain Research, Vol. 13). Elsevier, Amsterdam.

    Google Scholar 

  • — (1968). Development and maintenance of neurotrophic relations between nerve and muscle.-In: CIBA Foundation Symposium on Growth of the Nervous System. Little, Brown & Co.

  • — (1970). Open questions in the study of the “trophic” function of the nerve cell.-Topical Probl. Psychiat. Neurol.,10, p. 54–61.

    Google Scholar 

  • — &V. Hanzlikova (1967). Effects of accessory nerve study to muscle achieved by implantation into muscle during regeneration of its nerve.-Physiol. Bohemoslov.,16, p. 244–250.

    Google Scholar 

  • —, &P. Hnik (1962). Denervation studies in research of neurotrophic relationships.-In:E. Gutmann (ed.).The Denervated Muscle. Publ. House, Czecksl. Acad. Sci., Prague.

    Google Scholar 

  • —, &P. Hnik (eds.) (1963).The Effect of Use and Disuse on Neuromuscular Functions.-Elsevier, Amsterdam.

    Google Scholar 

  • Handelman, C., &H. Wells (1963). Morphological and histochemical studies of experimentally enlarged and atrophied salivary glands of rats.-Amer. J. Anat.,112–113, p. 65–79.

    Google Scholar 

  • Hansen, E. R. (1967a). Mitotic activity and cell densities in gingival epithelium of rats.-Odont. Tidsk.,75, p. 28–32.

    Google Scholar 

  • — (1967b). Mitotic activity and mitotic duration in tongue epithelium of rats.-Odont. Tidsk.,75, p. 473–479.

    Google Scholar 

  • — (1967c). Mitotic activity in tongue and gingival epithelium of adrenalectomized rats.-Odont. Tidsk.,75, p. 467–472.

    Google Scholar 

  • — (1967d). Mitotic activity and mitotic duration in tongue and gingival epithelium of mice.-Odont. Tidsk.,75, p. 480–487.

    Google Scholar 

  • Hay, Elizabeth D. (1960). The fine structure of nerves in the epidermis of regenerating salamander limbs.-Exp. Cell Res.,19, p. 299–317.

    Google Scholar 

  • Henkin, R. I. (1967a). Sensory mechanisms in familial dysautonomia.-In: J. F. Bosma (ed.).Symposium on Oral Sensation and Perception. C. C. Thomas, Springfield.

    Google Scholar 

  • — (1967b). The role of taste in disease and nutrition.-Borden Rev. Nutrit. Res.,28, p. 71–87.

    Google Scholar 

  • — (1967c). The definition of primary and secondary areas of olfaction as the basis for a classification of decreased olfactory acuity.-In:T. Hayashi (ed.).Olfaction and Taste (2nd Int. Symposium on Olfaction and Taste). Pergamon Press, Oxford.

    Google Scholar 

  • Henkin, R. I., R. L. Christiansen, &J. F. Bosma (1966). Impairment of recognition of oral sensation and familiar hyposmia in patients with facial hypoplasia and growth retardation: A new syndrome.-Clin. Res.,14, p. 236.

    Google Scholar 

  • — (1970). Facial hypoplasia, growth retardation, impairment of oral sensation and perception and hyposmia: A new syndrome.-In:J. F. Bosma (ed.).Second Symposium on oral Sensation and Perception. C. C. Thomas, Springfield.

    Google Scholar 

  • Henry, J. L., J. Meyer, J. P. Weinmann, &I. Schour (1952). Pattern of mitotic activity in oral epithelium of rabbits.-Arch. Path.,54, p. 281–297.

    Google Scholar 

  • Hochberg, I., &J. Kabcenell (1967). Oral stereognosis in normal and cleft palate individuals.-Cleft Palate J.,4, p. 47–57.

    Google Scholar 

  • Hogg, I. D. (1941). Sensory nerves and associated structures in the skin of human fetuses of 8 to 14 weeks of menstrual age correlated with functional capability. -J. Comp. Neurol.,75, p. 371–410.

    Google Scholar 

  • Hogg, I. D., &J. W. Bryant (1969). The development of sensory innervation in the mouth and pharynx of the albino Norway rat (Mus norvegicus albinus).-J. Comp. Neurol.,136, p. 33–56.

    Google Scholar 

  • Humphrey, T. (1966). The development of trigeminal nerve fibers to the oral mucosa, compared with their development to cutaneous surfaces.-J. Comp. Neurol.,126, p. 91–108.

    Google Scholar 

  • Jeppsson, P. H. (1969). Studies on the structure and innervation of taste buds.-Acta Oto-Laryng., Suppl.259, p. 5–95.

    Google Scholar 

  • Jones, D. P., &M. Singer (1969). Neurotrophic dependence of the lateral-line sensory organs of the newt,Triturus viridescens.-J. exp. Zool.,171, p. 433–442.

    Google Scholar 

  • Kanagasuntheram, R., W. C. Wong, &H. L. Chan (1969). Some observations on the innervation of the human nasopharynx.-J. Anat.,104, p. 361–376.

    Google Scholar 

  • Kantor, S., R. L. Kennett, Jr., &E. Waletzky (1970). Acetylcholine sensitivity of muscle fiber membranes: Mechanism of regulation by motoneurons.-Science,168, p. 372–374.

    Google Scholar 

  • Kerkut, G. A. (1967). The movements of chemicals in snail neurons.-In:J. Salanki (ed.).Neurobiology of Invertebrates. Plenum Press, N. Y.

    Google Scholar 

  • — (1967). Transport of material along nerves.-In: G. E. W. Wolstenholme &M. O'Connor (eds.).Growth of the Nervous System. Little, Brown and Co., Boston.

    Google Scholar 

  • Kischer, C. W. (1968). Fine structure of the down feather during its early development.-J. Morph.,125, p. 185–204.

    Google Scholar 

  • Korr, I. M. (1967). Axoplasmic transport.-In: Neurosci. Res. Prog. Bull.5 (u), p. 307–419.

    Google Scholar 

  • Lasek, R. J. (1970). Axonal transport of proteins in dorsal root ganglion cells of the growing cat: A comparison of growing and mature neurons.-Brain Res.,20, p. 121–126.

    Google Scholar 

  • Lebowitz, P., &M. Singer (1970). Neurotrophic control of protein synthesis in the regenerating limb of the newt,Triturus.-Nature,225, p. 824–827.

    Google Scholar 

  • Lentz, T. L. (1969). Development of the neuromuscular junction. I. Cytological and cytochemical studies on the neuromuscular junction of differentiating muscle in the regenerating limb of the newt,Triturus.-J. Cell Biol.,42, p. 143–443.

    Google Scholar 

  • — (1971). Nerve trophic function: In vitro assay of effects of nerve tissue on muscle cholinesterase activity.-Science,171, p. 187–189.

    Google Scholar 

  • Lischka, M. (1969). Das juxtuorale Organ der Ratte nach Denervierung.-Z. Anat. Entw.-Gesch.,129, p. 268–273.

    Google Scholar 

  • Locke, J. L. (1968). Oral perception and articulation learning.-Percept. Motor Skills,26, 1, p. 259–61, p. 264.

    Google Scholar 

  • Lubinska, L. (1964). Axoplasmic streaming in regenerating and in normal nerve fibers.-In:M. Singer &J. P. Schade (eds.).Mechanisms of Neural Regeneration (Progress in Brain Research, Vol. 13). Elsevier, Amsterdam.

    Google Scholar 

  • Manly, R. S., C. Pfaffman, D. D. Lathrop, &J. Keyser (1952). Oral sensory thresholds of persons with natural and artificial dentitions.-J. Dent. Res.,31, p. 305–312.

    Google Scholar 

  • Mann, W. S., &B. Salafsky (1970). Enzymic and physiological studies on normal and disused developing fast and slow cat muscles.-J. Physiol.,208, p. 33–47.

    Google Scholar 

  • Massengill, R., Jr.,M. S. K. Pickrell, &J. Fetterrolf (1968). Relationship between articulation errors and other factors in children with cleft palates.-Plast. Reconstr. Surg.,41, p. 564–567.

    Google Scholar 

  • Mavrinskaya, L. F. (1960). On correlation of development of skeletal muscle nerve endings with appearance of motor activity in human embryo.-Arkh. Anat. Gist. Embr.,38, p. 61–68.

    Google Scholar 

  • Messier, B., &C. P. Leblond (1959–'60). Cell proliferation and migration as revealed by radio-autography after injection of thymidine-H3 into male rats and mice.-Amer. J. Anat.,105–106, p. 247–285.

    Google Scholar 

  • Meyer, J., H. Medak, &J. P. Weinmann (1960). Mitotic activity and rates of growth in regions of oral epithelium differing in width.-Growth,24, p. 29–46.

    Google Scholar 

  • Miani, N. (1964). Proximo-distal movement of phospholipid in the axoplasm of the intact and regenerating neurons.-In:M. Singer &J. P. Schade (eds.).Mechanisms of Neural Regeneration (Progress in Brain Research, Vol. 13), p. 115–116. Elsevier, Amsterdam.

    Google Scholar 

  • Mizell, M., &J. J. Isaacs (1970). Induced regeneration of hind limbs in the new-born opossum.-Amer. Zool.,10, p. 141–155.

    Google Scholar 

  • Mommaerts, W. F. H. M., A. J. Buller, &K. Seraydarian (1969). The modification of some biochemical properties of muscle by cross-innervation.-Proc. Nat. Acad. Sci.,64, p. 128–133.

    Google Scholar 

  • Moss, M. L. (1971). Neurotrophic processes in oro-facial growth.-J. Dent. Res.,50, 1, p. 492–1, 494.

    Google Scholar 

  • Moss, M. L., &L. Salentijn (1969a) The primary role of functional matrices in facial growth.-Amer. J. Orthod.,55, p. 566–577.

    Google Scholar 

  • — (1969b). The capsular matrix.-Amer. J. Orthod.,56, p. 474–490.

    Google Scholar 

  • — (1970). The logarithmic growth of the human mandible.-Acta Anat.,77, p. 341–360.

    Google Scholar 

  • — (1971). Morphological attributes of the logarithmic growth of the human face: gnomic growth.-Acta Anat.,78, p. 185–199.

    Google Scholar 

  • Muchmore, W. B. (1968). The influence of neural tissue on the early development of somatic muscle in ventro-lateral implants inAmbystoma.-J. exp. Zool.,169, p. 251–258.

    Google Scholar 

  • Oakley, B. (1967). Altered taste responses from cross-regenerated taste nerves in the rat.-In:T. Hayashi (ed.).Olfaction and Taste. II. Hayashi. Pergamon Press, N. Y.

    Google Scholar 

  • — (1969). Taste preference following cross-innervation of rat fungiform taste buds.-Physiol. Behav.,4, p. 929–933.

    Google Scholar 

  • Ohe, K. (1970). Metabolic dependence of fast axoplasmic transport in nerve.-Science,167, p. 878–880.

    Google Scholar 

  • Orfanos, C. (1965). Elektronenmikroskopische Befunde an epidermisnahen Nervenanteilen.-Arch. Klin. Exp. Derm.,222, p. 603–612.

    Google Scholar 

  • Osmanski, C. P., &J. Meyer (1967). Differences in the fine structure of the mucosa of mouth, cheek and palate.-J. Invest. Derm.,48, p. 309–317.

    Google Scholar 

  • Overton, J. (1950). Mitotic stimulation of amphibian epidermis by underlying grafts of central nervous tissue.-J. exp. Zool.,115, p. 521–559.

    Google Scholar 

  • — (1965). Mitotic responses in amphibian epidermis to feeding and grafting.-J. exp. Zool.,130, p. 433–483.

    Google Scholar 

  • Prewitt, M. A., &B. Salafsky (1970). Enzymic and histochemical changes in fast and slow muscles after cross-innervation.-Amer. J. Physiol.,218, p. 69–74.

    Google Scholar 

  • Redler, P., &E. S. Lustig (1970). Control of epithelial development in normal and pathological connective tissue.-Developm. Biol.,22, p. 84–95.

    Google Scholar 

  • Robbins, N. (1967). The role of the nerve in maintenance of frog taste buds.-Exp. Neurol.,17, p. 364–380.

    Google Scholar 

  • — (1970). Trophic effect of gustatory nerves.-In:J. F. Bosma (ed.).2nd Symposium on Oral Sensation and Perception. C. C. Thomas, Springfield.

    Google Scholar 

  • Rose, S. M. (1962). Tissue-arc control of regeneration in the amphibian limb.-In:D. Rudnick (ed.)Regeneration. Ronald Press, N. Y.

    Google Scholar 

  • Saito, A., &S. I. Zacks (1969). Fine structure observations of denervation and reinnervation of neuromuscular junctions in mouse foot muscle.-J. Bone Jt. Surg.,51-A: 1, 163–71, 177.

    Google Scholar 

  • Samaha, F. J., L. Guth, &R. W. Albers (1970). The neural regulation of gene expression in the muscle cell.-Exp. Neurol.,27, p. 276–282.

    Google Scholar 

  • Sandow, A. (1970). Skeletal muscle.-Annu. Rev. Physiol.,32, p. 87–138.

    Google Scholar 

  • Sangiacomo, C. O. (1969). Denervated taste buds. I. General ultrastructural observations.-Experientia,25, 1, p. 323–1,324.

    Google Scholar 

  • Sharav, Y., &M. Massler (1967). Age changes in oral epithelia.-Exp. Cell Res.,47, p. 132–138.

    Google Scholar 

  • Shimada, Y., D. A. Fischman, &A. A. Moscona (1969). The development of nerve-muscle junctions in monolayer cultures of embryonic spinal cord and skeletal muscle cells.-J. Cell Biol.,43, p. 382–387.

    Google Scholar 

  • Singer, M. (1952). The influence of the nerve in regeneration of the amphibian extremity.-Quart Rev. Biol.,27, p. 169–200.

    Google Scholar 

  • — (1954). Induction of regeneration of the forelimb of the postmetamorphic frog by augmentation of the nerve supply.-J. exp. Zool.,126, p. 419–472.

    Google Scholar 

  • — (1963). Nervous control of the regrowth of body parts in vertebrates.-In:E. Gutmann &P. Hnik (eds.).The Effect of Use and Disuse on Neuromuscular Functions. Elsevier, Amsterdam.

    Google Scholar 

  • Singer, M., &L. Craven (1948). The growth and morphogenesis of the regenerating forelimb of adultTriturus following denervation at various stages of development.-J. exp. Zool.,108, p. 279–308.

    Google Scholar 

  • Spillane, J. D., &C. E. C. Wells (1969).-In:Acrodystrophic Neuropathy. London Oxford Univ. Press, N.Y.

    Google Scholar 

  • Steen, T. P. (1970). Origin and differentiative capacities of cells in the blastema of the regenerating salamander limb.-Amer. Zool.,10, p. 119–123.

    Google Scholar 

  • Studitsky, A., R. Zhenevskaya, &O. Rumyantseva (1962). The role of neurotrophic influence upon the restitution of structure and function of regenerating muscles.-In:E. Gutmann &P. Hnik (eds.).The Effect of Use and Disuse on Neuromuscular Functions. Elsevier, Amsterdam.

    Google Scholar 

  • Susi, F. R. (1968). Studies of cellular renewal and protein synthesis in mouse oral mucosa utilizing H3-thymidine and H3-cystine.-J. Invest. Derm.,51, p. 403–408.

    Google Scholar 

  • Thornton, C. S. (1954). The relation of epidermal innervation to limb regeneration inAmbystoma larvae.-J. exp. Zool.,127, p. 577–597.

    Google Scholar 

  • — (1970). Amphibian limb regeneration and its relation to nerves.-Amer. Zool.,10, p. 113–118.

    Google Scholar 

  • Thornton, C. S., &M. T. Thornton (1970). Recuperation of regeneration in denervated limbs ofAmbystoma larvae.-J. exp. Zool.173, p. 293–302.

    Google Scholar 

  • Toto, P. D., &G. Ojha (1962). Generation cycle of oral epithelium in mice.-Dent. Res.,41, p. 388–391.

    Google Scholar 

  • Tower, S. S. (1939). The reaction of muscle to denervation.-Physiol. Rev.,19, p. 1–48.

    Google Scholar 

  • van Stone, J. M. (1955). The relationship between innervation and regenerative capacity in hind limbs ofRana sylvatica.-J. Morph.,97, p. 345–391.

    Google Scholar 

  • Venerone, G., &M. R. Murray (1969). Formation de novo and development of neuromuscular junctions in vitro.-J. Embryol. Exp. Morph.,21, p. 369–382.

    Google Scholar 

  • Vij, S., &R. Kanagasuntheram (1969). Innervation of oral tissues in some primates.-Folia Primat.,11, p. 289–299.

    Google Scholar 

  • Weis, J. S., &P. Weis (1970). The effect of nerve growth factor on limb regeneration inAmbystoma.-J. exp. Zool.,174, p. 73–78.

    Google Scholar 

  • Weiss, P. A. (1969). “Panta Rhei”-and so flow our nerves.-Amer. Scient.,57, p. 287–305.

    Google Scholar 

  • Winkelman, R. R. (1960).Nerve Endings in Normal and Pathologic Shin.-C. C. Thomas, Springfield.

    Google Scholar 

  • Yellin, Herbert (1969). Unique intrafusal and extraocular muscle fibers exhibiting dual actomyosin atpase activity. -Exp. Neurol.,25, p. 153–163.

    Google Scholar 

  • Yohro, T. (1969). The mitotic pattern of the embryonic epidermis of chick during scale morphogenesis.-J. Embryol. Exp. Morph.,21, p. 235–242.

    Google Scholar 

  • Young, J. Z. (1968). Influence of the mouth on the evolution of the brain.-In: P. Person (ed.).Biology of the Mouth. Publ.89: 21–35, A.A.A.S., Washington.

    Google Scholar 

  • Zalewski, A. A. (1968). Changes in phosphatase enzymes following denervation of the vallate papilla of the rat.-Exp. Neurol.,22, p. 40–51.

    Google Scholar 

  • — (1969a). Neurotrophic-hormonal interaction in the regulation of taste buds in the rat's vallate papilla.-J. Neurol.,1, p. 123–132.

    Google Scholar 

  • — (1969b). Regeneration of taste buds after reinnervation by peripheral or central sensory fibers of vagal ganglia.-Exp. Neurol.,25, p. 429–437.

    Google Scholar 

  • — (1969c). Combined effects of testosterone and motor, sensory, or gustatory nerve reinnervation on the regeneration of taste buds.-Exp. Neurol.,24, p. 285–297.

    Google Scholar 

  • — (1969d). Role of nerve and epithelium in the regulation of alkaline phosphatase activity in gustatory papillae.-Exp. Neurol.,23, p. 18–28.

    Google Scholar 

  • Zelena, J. (1964). Development, degeneration and regeneration of receptor organs.-In:M. Singer &J. P. Schade (eds.).Mechanisms of Neural Regeneration (Progress in Brain Research, Vol. 13). Elsevier, Amsterdam.

    Google Scholar 

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Moss, M.L. An introduction to the neurobiology of oro-facial growth. Acta Biotheor 21, 236–259 (1972). https://doi.org/10.1007/BF01557180

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