Skip to main content
Log in

The autocatalytic growth model

I. Critical analysis of the conceptual framework

  • Published:
Acta Biotheoretica Aims and scope Submit manuscript

Summary

Because of the important role which the ‘autocatalytic’ or ‘logistic’ equation has played in determining the direction of a good deal of research both in demography and in the study of individual growth phenomena, a critical and comparative evaluation of those leading ideas inRobertson's (1923) book which pertain to this equation and of some of the criticisms levelled against it seemed to be of interest. The present paper shows that, contrary to common belief,Robertson did not really assume that the autocatalytic reactions to which he compared growth processes, took place in closed systems (viz., cells). On the other hand, he does not seem to have found a satisfactory representation of how the growth phenomena of the individual cells in an organism might interact to yield the overall growth of the organism as a whole. Nor is the manner in which he made his equation account for the openness of the individual cells free from possible criticism. An alternative equation is here proposed, which will be discussed in another paper. The properties of the solutions of this equation are such that the autocatalytic theory might never have gained a foothold if this, more realistic, equation would have been the object of the initial studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Booy, H. L. andH. R. Wolvekamp (1944), Catenary processes, master reactions and limiting factors.- Bibliotheca Biotheoretica, Vol. 1, pars 4, pp. 145–224, with folded table; Leiden, Brill.

    Google Scholar 

  • Bray, H. G. andK. White (1966), Kinetics and thermodynamics in biochemistry. - London, J. & A. Churchill; New York, Academic Press; xi + 418 pp.

    Google Scholar 

  • Crozier, W. J. (1926), On curves of growth, especially in relation to temperature. - The Journal of General Physiology 10, pp. 53–73.

    Google Scholar 

  • Moore, M. J. (1949), Kinetics of open reaction systems; chains of simple autocatalytic reactions.- Transactions of the Faraday Society 45, pp. 1098–1109.

    Google Scholar 

  • Needham, A. E. (1964), The growth process in animals.- Princeton, Van Nostrand, xiv + 522 pp.

    Google Scholar 

  • Pearl, R. andL. J. Reed (1920), On the rate of growth of the population of the United States since 1790 and its mathematical representation.- Proceedings of the National Academy of Sciences of the United States 6, pp. 275–288.

    Google Scholar 

  • Perret, C. J. andH. C. Levey (1961), The theory of uncatalysed linear expanding systems.- Journal of Theoretical Biology 1, pp. 542–550.

    Google Scholar 

  • Robertson, T. B. (1908), On the normal rate of growth of an individual and its biochemical significance.- Arch. f. Entwicklungsmech. der Organismen 25, pp. 581–614.

    Google Scholar 

  • — (1908), Further remarks on the normal rate of growth of an individual, and its biochemical significance.- Arch. f. Entwicklungsmech. der Organismen 26, pp. 108–118.

    Google Scholar 

  • — (1923), The chemical basis of growth and senescence.- Philadelphia & London, J. B. Lippincott, viii + 389 pp.

    Google Scholar 

  • Snell, G. D. (1929), An inherent defect in the theory that growth rate is controlled by an autocatalytic process.- Proc. Nat. Acad. Sci. U.S. 15, pp. 274–281.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This research was in part supported by NIH training grant GM-678.

Rights and permissions

Reprints and permissions

About this article

Cite this article

van der Vaart, H.R. The autocatalytic growth model. Acta Biotheor 18, 133–142 (1968). https://doi.org/10.1007/BF01556724

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01556724

Keywords

Navigation