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Non-infectious intracisternal A-type particles in a sarcoma-positive, leukemia-negative mouse cell line transformed by murine sarcoma virus (MSV)

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Summary

Cell lines derived from C3H mouse embryos are described. Untransformed MO-cells were found susceptible to transformation by Kirsten MSV. Two types of transformed cell lines were isolated. MO-P-cells produced infectious MSV and contained extracellular C-type particles. MO4-cells did not release infectious focus forming virus; however, upon superinfection with murine leukemia viruses (MLV), infectious MSV was released. Not superinfected MO4-cells contained multiple intracisternal A-type particles. In this respect these cells differ from the MSV genome-carrying NP-cells (1) which do not produce particles nor viral antigen, and from S+L−-cells (2) which release extracellular, non-infectious C-type particles.

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  1. A. Billiau

    Present address: Department of Microbiology, Rega Institute, University of Leuven, Leuven, Belgium

Authors and Affiliations

  1. Department of Microbiology, Rega Institute, University of Leuven, Leuven, Belgium

    H. Sobis, H. Eyssen & H. van den Berghe

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  1. A. Billiau
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  2. H. Sobis
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  3. H. Eyssen
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  4. H. van den Berghe
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Billiau, A., Sobis, H., Eyssen, H. et al. Non-infectious intracisternal A-type particles in a sarcoma-positive, leukemia-negative mouse cell line transformed by murine sarcoma virus (MSV). Archiv f Virusforschung 43, 345–351 (1973). https://doi.org/10.1007/BF01556151

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  • DOI: https://doi.org/10.1007/BF01556151

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