Abstract
Roentgenological examination of the skull in 11 male-to-female transsexuals revealed considerable asymmetry (2.5–3 mm) of the sellar floor in three cases. There was no asymmetry exceeding 1.5 mm in 103 male controls. Asymmetry of the sella turcica suggests the presence of an intrasellar pituitary tumor. This finding in three patients with transsexualism is of interest in view of reports of endocrine disorders or hormonal secretion abnormalities in patients with atypical sexuality or gender identity problems.
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References
Bergström, K., Lundberg, P. O., and Sjövall, A. (1973). The volume of the sella turcica in patients with anorexia nervosa.Eur. Neurol. 9: 183–189.
Bleuler, M. (1954).Endokrinologische Psychiatrie G. Thieme Verlag, Stuttgart.
Deck, M. D. F. (1973). Radiographic and radioisotopic techniques in diagnosis of pituitary tumors. In Kohler, P. O., and Ross, G. T. (eds.),Diagnosis and Treatment of Pituitary Tumors Excerpta Medica, Amsterdam, pp. 71–85.
di Chiro, G. (1960). The width (third dimension) of the sella turcica.Am. J. Roentgenol. 84: 26–37.
Dörner, G., Rohde, W., and Krell, L. (1972). Auslösung eines positiven Östrogenfeedback-Effekt bei homosexuellen Männern.Endokrinologie 3: 297–301.
Erhardt, A. (1969). Zur Wirkung fötaler Hormone auf Intelligenz und geschlechtsspezifisches Verhalten. Dissertation, Düsseldorf.
Erhardt, A., and Money, J. (1967). Progestin-induced hermaphroditism: IQ and psychosexual identity in a study of ten girls.J. Sex. Res. 3: 83–100.
Erhardt, A., Epstein, R., and Money, J. (1968). Fetal androgens and female gender identity in the early-treated adrenogenital syndrome.Johns Hopkins Med. J. 122: 160–167.
Hardy, J. (1973). Transsphenoidal surgery of hypersecreting pituitary tumors. In Kohler, P. O., and Ross, G. T. (eds.),Diagnosis and Treatment of Pituitary Tumors Excerpta Medica, Amsterdam, pp. 179–194.
Hoenig, J., and Kenna, J. C. (1974). The prevalence of transsexualism in England and Wales.Brit. J. Psychiat. 124: 181–190.
Kaufman, B., Pearson, O. H., and Chamberlin, W. B. (1973). Radiographic features of intrasellar masses and progressive asymmetrical non-tumorous enlargements of the sella turcica, the “empty” sella. In Kohler, P. O., and Ross, G. T. (eds.),Diagnosis and Treatment of Pituitary Tumors Excerpta Medica, Amsterdam, pp. 100–129.
Kolodny, R. C., Masters, W. H., Hendryx, J., and Toro, G. (1971). Plasma testosteron and semen analysis in male homosexuals.New Engl. J. Med. 185: 1170–1174.
Kolodny, R. C., Jacobs, L. S., Masters, W. H., Toro, G., and Daughaday, W. H. (1972). Plasma gonadotrophins and prolactin in male homosexuals.Lancet ii: 18–20.
Loraine, J. A., Ismail, A. A. A., Adamopoulos, D. A., and Dove, G. A. (1970). Endocrine function in male and female homosexuals.Brit. Med. J. 4: 406–408.
Margolese, M. S., and Janiger, O. (1973). Androsterone/etiocholanolone ratios in male homosexuals.Brit. Med. J. 3: 207–210.
McLachlan, M. S. F., Wright, A. D., and Doyle, F. H. (1970). Plain film and tomographic assessment of the pituitary fossa in 140 acromegalic patients.Brit. J. Radiol. 43: 360–369.
Money, J. (1972a). Phyletic and idiosyncratic determinants of gender identity.Dan. Med. Bull. 19: 259–262.
Money, J. (1972b). Identification and complementation in the differentiation of gender identity.Dan. Med. Bull. 19: 265–268.
Newton, T. H., and Potts, D. G., eds. (1971).Radiology of the Skull and Brain: The Skull, Vol. 1/Book 1, Mosby, St. Louis, Missouri, pp. 374–377.
Radberg, C. (1963). Some aspects of the asymmetric enlargement of sella turcica.Acta Radiol. (Diagn.). 1: 152–163.
Ross, R., and Greitz, T. (1966). Changes of the sella turcica in chromophobic adenomas and eosinophilic adenomas.Radiology 86: 892–899.
Routier, G., Paget, M., Ernst, J., Langeron, P., Wiart, P., Duthoit, F., and Cousin, J. (1964). Tumeur féminisante de la surrénale et transsexualism.Ann. Endocrinol. 25: 680–685.
Routier, G., Ernst, J., and Paget, M. (1970). Le transsexualisme: Valeur respective des déterminants biologiques et psychiques.Sem. Hop. Paris 46: 947–952.
Sendrail, M., and Gleizes, L. (1961). Le trans-sexualisme feminin et le problème de ses conditions psychiques ou hormonales.Rev. Fr. Endocrinol.-Clin. 2: 35–43.
Tönnis, W., Friedmann, G., and Albrecht, H. (1957). Zur röntgenologischen Differentialdiagnose der Hypophysenadenome (Unter besonderer Berücksichtigung der primären und sekundären Sellaveränderungen).Fortschr. Geb. Röntgenstrahlen 87: 677–686.
Vezina, J. L., and Sutton, T. J. (1974). Prolactin-secreting pituitary microadenomas: Roentgenologic diagnosis.Am. J. Roentgenol. 120: 46–54.
Wålinder, J. (1967).Transsexualism: A Study of Forty-three Cases Scandinavian University Books, Akademiförlaget, Göteborg.
Yalom, I. D. (1973). Prenatal exposure to female hormones: Effect on psychosexual development in boys.Arch. Gen. Psychiat. 28: 554–561.
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Lundberg, P.O., Sjövall, A. & Wålinder, J. Sella turcica in male-to-female transsexuals. Arch Sex Behav 4, 657–662 (1975). https://doi.org/10.1007/BF01544273
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DOI: https://doi.org/10.1007/BF01544273