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Cybernetics of blood sugar and fat in health and disease

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Resumen

El A. considera que la obesidad, la aterosclerosis y la diabetes mellitus son complicaciones del trastorno en los sistemas de recíproco control comprometidos en el área del metabolismo de los carbohidratos. Una anormal secreción de insulina determina una secreción contrarreguladora de somathormonas, catecolaminas, noradrenalina y adrenalina. De ello resulta un alterado metabolismo lipídico y una hiperlipemia. En el trascurso de la vida, con el proceso de envejecimiento, estos trastornos determinan un aumento de la frecuencia de la diabetes mellitus y de la aterosclerosis. Se discute la cibernética de esta alteración.

Zusammenfassung

Der A. vertritt die Auffassung, dass die Fettsucht, Atherosklerose und der Diabetes mellitus Komplikationen der Stoerung in den Systemen wechselseitiger Kontrolle darstellen, welche auf der Hoehe des Kohlehydratstoffwechsels ihre Wirkung entfalten. Eine abnorme Insulinsekretion bewirkt eine kontraregulatorische Sekretion von Somatohormonen, Katecholaminen, Noradrenalin und Adrenalin. Es folgen ein veraenderter Fettstoffwechsel sowie Hyperlipaemie. Diese Stoerungen im Laufe des Lebens bewirken Zunahme der Frequenz des Diabetes mellitus und der Atherosklerose waehrend des Alterns. Es wird die Kibernetik dieser Veraenderung diskutiert.

Summary

It is the Author's view that obesity, atherosclerosis and diabetes mellitus represent complications of a disturbance in the feedback control systems involved in the area of carbohydrate metabolism. Inappropriate insulin secretion causes counter regulatory release of growth hormone and the catecholamines, noradrenaline and epinephrine. Resulting is a disturbance in fat metabolism and hyperlipemia. Over the span of a lifetime these disturbances result in increasing frequency of diabetes mellitus and atherosclerosis with the aging process. The cybernetics of this derangement is discussed.

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Bibliografia

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Authors and Affiliations

  1. Physiochemical Automation Laboratory, Cedars-Sinai Medical Center, 9201 Sunset Boulevard, Los Angeles, California, USA

    Arnold Henry Kadish (Senior Research Fellow in Engineering)

  2. California Institute of Technology, Pasadena, California, USA

    Arnold Henry Kadish (Senior Research Fellow in Engineering)

Authors
  1. Arnold Henry Kadish
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Kadish, A.H. Cybernetics of blood sugar and fat in health and disease. Acta diabet. lat 4, 36–44 (1967). https://doi.org/10.1007/BF01543813

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  • DOI: https://doi.org/10.1007/BF01543813

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