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Genetics of cell-surface antigens: Regional mapping of three components of the human cell-surface antigen complex, Al, on chromosome 11

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Somatic Cell Genetics

Abstract

Cytogenetic analysis has been performed on a series of deletion mutations on human chromosome 11 of AL hybrid clones in which specific markers have been lost as a result of treatment with mutagenic agents. Such analysis has localized the three previously identified components of the AL cell-surface antigen complex to the indicated regions of chromosome 11: a1 and a3:11p13 → 11pter; a2: 11q13 → 11qter. Using these methodologies human lactic dehydrogenase A localization on the short arm as reported by others has been confirmed. Evidence is presented provisionally assigning this gene to 11p13 → 11pter.

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Authors and Affiliations

  1. Eleanor Roosevelt Institute for Cancer Research, University of Colorado Medical Center, B129, 4200 East Ninth Avenue, 80262, Denver, Colorado

    Fa-Ten Kao, Carol Jones & Theodore T. Puck

Authors
  1. Fa-Ten Kao
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  2. Carol Jones
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  3. Theodore T. Puck
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Additional information

This paper is No. 7 in this series and also No. 23 in the series entitled “Genetics of Somatic Mammalian Cells.”

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Kao, FT., Jones, C. & Puck, T.T. Genetics of cell-surface antigens: Regional mapping of three components of the human cell-surface antigen complex, Al, on chromosome 11. Somat Cell Mol Genet 3, 421–429 (1977). https://doi.org/10.1007/BF01542970

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  • DOI: https://doi.org/10.1007/BF01542970

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