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Somatic diversification of antibody responses

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Conclusions

During the last decade, a substantial body of knowledge has been obtained on the generation of somatic diversification of the B cell repertoire, especially with regard to differentiation and selection of B cells in specialized microenvironments such as GCs and GALTs which are similar to each other morphologically and physiologically. Although the mechanisms for somatic diversification remain unclear, with advances in histo- and cytochemical and molecular genetic techniques, some important issues such as the cellular interactions and signals involved in differentiation and selection have been approached and/or identified. Phylogenetic studies will be important to understand relationships between distinct developmental pathways and different lymphoid tissues in various species during evolution.

Biologists will need the reconciliation of three views to gain the real comprehension of immunity: responses of individual cells to intra- and extracellular stimuli, responses of distinct cell populations to each other, and responses of organisms and/or species to their environment in order to survive.

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  1. Department of Microbiology and Immunology, University of Maryland School of Medicine, 655 West Baltimore Street, 21201-1559, Baltimore, Maryland

    Biao Zheng, Garnett Kelsoe & Shuhua Han

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  1. Biao Zheng
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  2. Garnett Kelsoe
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  3. Shuhua Han
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Zheng, B., Kelsoe, G. & Han, S. Somatic diversification of antibody responses. J Clin Immunol 16, 1–11 (1996). https://doi.org/10.1007/BF01540967

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  • DOI: https://doi.org/10.1007/BF01540967

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