Abstract
Chinese hamster × mouse hybrid cells segregating mouse chromosomes have been used to assign a gene for triosephosphate isomerase (TPI-1, EC 5.3.1.1, McKusick #19045) to mouse chromosome 6, and a gene for Glyoxalase-I (GLO-1, EC4.4.1.5, McKusick #13875) to mouse chromosome 17. The genes for TPI-1 and lactate dehydrogenase B are syntenic in man and probably so in the dog. It is therefore likely that they are syntenic also in the mouse. It is of interest then that there is a mouse gene,Ldr-1, on chromosome 6 that regulates the level of LDH B subunits in mouse erythrocytes. The locus for GLO-1 is closely linked to the major histocompatibility complex in man. Since the major histocompatibility complex in the mouse is present on chromosome 17, this locus and theGlo-1 locus are syntenic in the mouse as well. This finding adds to the number of autosomal gene pairs which are syntenic in both mouse and man and reinforces the belief that there is considerable conservation of linkage groups during evolution.
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Miller, O. R., and Miller, D. A. (1975).Ann. Rev. Genet. 9:285–303.
Chapman, V. M. (1975).Biochem. Genet. 13:849–856.
Minna, J. D., and Coon, H. G. (1974).Nature 252:401–404.
Minna, J. D., Marshall, T. H., and Shaffer-Berman, P. V. (1975).Somat. Cell Genet. 1:355–369.
Minna, J. D., Lalley, P. A., and Francke, U. (1976).In Vitro 12:726–733.
Kozak, C. E., Nichols, E., and Ruddle, F. H. (1975).Somat. Cell Genet. 1:371–382.
Francke, U., Lalley, P. A., Moss, W., Ivy, J., and Minna, J. D. (1977).Cytogenet. Cell Genet. 19:57–85.
Bergsma, D. (Ed.) (1977).Human Gene Mapping 4, Winnipeg Conference (1977). Birth Defects;Original Article Series, The National Foundation-March of Dimes, New York, (in press).
Roderick, T. H., and Pearson, P. (1978).Winnipeg Conference (1977). Fourth International Workshop on Human Gene Mapping.Birth Defects: Original Article Series, The National Foundation-March of Dimes, New York, (in press).
Lalley, P. A., Francke, U., and Minna, J. D. (1978).Winnipeg Conference (1977). Fourth International Workshop on Human Gene Mapping.Birth Defects: Original Article Series, The National Foundation-March of Dimes, New York, (in press).
McKusick, V. A., and Ruddle, F. H. (1977).Science 196:390–405.
McKusick, V. A. (1975).Mendelian Inheritance in Man.Fourth Edition. The Johns Hopkins University Press, Baltimore.
Jongsma, A. P. M., Los, W. R. T., and Hagemeijer, A. (1974).Cytogenet. Cell Genet. 13:106–107.
Weitkamp, L. R., and Guttormsen, S. A. (1976).Baltimore Conference (1975). Third International Workshop on Human Gene Mapping.Birth Defects: Original Article Series, The National Foundation-March of Dimes, New York,12:364–366.
Meera Khan, P., Volkers, W. S., Doppert, B. A., Bijnen, A. B., Schreuder, I., and van Rodd, J. J. (1976).Baltimore Conference (1975). Third International Workshop on Human Gene Mapping.Birth Defects: Original Article Series, The National Foundation-March of Dimes, New York,12:328–330.
Francke, U., and Pellegrino, M. A. (1977).Proc. Natl. Acad. Sci. USA 74:1147–1151.
Weitkamp, L. and Francke, U. (1978).Winnipeg Conference(1977). Fourth International Workshop on Human Gene Mapping. Birth Defects: Original Article Series, The National Foundation-March of Dimes, (in press).
Davidson, R. L., and Gerald, P. S. (1977).Meth. Cell Biol. 15:325–338.
Harris, H., and Hopkinson, D. A. (1976).Handbook of Enzyme Electrophoresis in Human Genetics. American Elsevier, New York.
van Someren, H. (1974). Thesis, University of Leiden, Leiden, Holland.
Parr, C. W., Bagster, I. A., and Welch, S. G. (1977).Biochem. Genet. 15:109–113.
Bruns, G. A. P., and Gerald, P. S. (1976).Science 192:54–56.
McBreen, P., Engel, E., and Croce, C. M. (1978).Winnipeg Conference (1977). Fourth International Workshop of Human Gene Mapping.Birth Defects: Original Article Series, The National Foundation-March of Dimes, New York, (in press).
Meo, T., Douglas, T., and Runbeek, A. M. (1977).Science 198:311–313.
Jackson, F. J., Currier, R. D., Terasaki, T. I., and Morton, N. E. (1977).N. Engl. J. Med. 296:1138–1141.
Warburton, D., and Pearson, P. L. (1976).Baltimore Conference (1975). Third International Workshop on Human Gene Mapping.Birth Defects: Original Article Series, The National Foundation-March of Dimes, New York,12:75–82.
Snell, G. D. (1968).Folia Biol. (Prague) 14:335–359.
Bennett, D. (1975). Cell6:441–454.
Bobrow, M., Bodmer, J. D., Bodmer, W. F., McDevitt, H. O., Lorber, J., and Swift, P. (1975).Tissue Antigens 5:234–237.
Bruns, G. A. P., Pierce, P., Regina, V. M., and Gerald, P. S. (1978).Winnipeg Conference (1977). Fourth International Workshop on Human Gene Mapping.Birth Defects: Original Article Series, The National Foundation-March of Dimes, New York (in press).
Shows, T. B., and Ruddle, F. H. (1968).Proc. Natl. Acad. Sci. USA 61:574–581.
Hutton, J. J., and Roderick, T. H. (1970).Biochem. Genet. 4:339–350.
Swank, R. T., Paigen, K., and Ganschow, R. E. (1973).J. Mol. Biol. 81:225–243.
Lalley, P. A., and Shows, T. B. (1974).Science 185:442–444.
Breen, G. A. M., Lusis, A. J., and Paigen, K. (1977).Genetics 85:73–84.
Lalley, P. A., Francke, U., and Minna, I. D. (1978).Proc. Natl. Acad. Sci. USA (in press).
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Minna, J.D., Bruns, G.A.P., Krinsky, A.H. et al. Assignment of aMus musculus gene for triosephosphate isomerase to chromosome 6 and for Glyoxalase-I to chromosome 17 using somatic cell hybrids. Somat Cell Mol Genet 4, 241–252 (1978). https://doi.org/10.1007/BF01538988
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DOI: https://doi.org/10.1007/BF01538988