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The proopiocortin (adrenocorticotropin/β-lipotropin) gene is located on chromosome 2 in humans

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Somatic Cell Genetics

Abstract

The proopiocortin gene is located on chromosome 2 in humans. A 13-kb DNA fragment containing proopiocortin gene sequences was identified in human cells while proopiocortin-related gene sequences of 9.8 and 6.2 kb were present in mouse cells. In human-mouse cell hybrids which contained reduced numbers of human chromosomes and a complete set of mouse chromosomes, the 9.8- and 6.2-kb fragments were always present while the 13-kb fragment segregated with human chromosome 2 and the chromosome 2 enzyme markers acid phosphatase-1 (ACP1), malate dehydrogenase-1 (MDH1), and isocitrate dehydrogenase-1 (IDH1). Analysis of a single cell hybrid with a broken chromosome 2 indicates that the proopiocortin andACP1 genes are closely linked and in the distal region of the short arm of chromosome 2.

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Literature cited

  1. Mains, R.E., Eipper, B.A., and Ling, N. (1977).Proc. Natl. Acad. Sci. U.S.A. 74:3014–3018.

    Google Scholar 

  2. Roberts, J.L., and Herbert, E. (1977).Proc. Natl. Acad. Sci. U.S.A. 74:4826–4830.

    Google Scholar 

  3. Roberts, J.L., and Herbert, E. (1977).Proc. Natl. Acad. Sci. U.S.A. 74:5300–5304.

    Google Scholar 

  4. Nakanishi, S., Inoue, A., Taii, S., and Numa, S. (1977).FEBS Lett. 84:105–109.

    Google Scholar 

  5. Eipper, B.A., and Mains, R.E. (1978).J. Biol. Chem. 253:5732–5744.

    Google Scholar 

  6. Roberts, J.L., Phillips, M.A., Rosa, P.A., and Herbert, E. (1978).Biochemistry 17:3609–3618.

    Google Scholar 

  7. Mains, R.E., and Eipper, B.A. (1979).J. Biol. Chem. 254:7885–7894.

    Google Scholar 

  8. Larson, L. (1977).Lancet 2:1321–1323.

    Google Scholar 

  9. Liotta, A., Osathanondh, R., Ryan, K.J., and Krieger, D.T. (1977).Endocrinology 101:1552–1558.

    Google Scholar 

  10. Rees, L.H., Burke, C.W., Chard, T., Evans, S.W., and Letchworth, A.T. (1975).Nature 254:620–622.

    Google Scholar 

  11. Linnoila, R.J., Lazarus, L.H., Kahn, M.N., and DiAugustine, R.P. (1981).Nature (in press).

  12. Krieger, D.T., and Liotta, A. (1979).Science 205:366–372.

    Google Scholar 

  13. Bertanga, X.Y., Nicholson, W.E., Sorenson, G.D., Pettengill, O.S., Mount, C.D., and Orth, D.N. (1978).Proc. Natl. Acad. Sci. U.S.A. 75:5160–5164.

    Google Scholar 

  14. Miller, W.L., Johnson, L.K., Baxter, J.D., and Roberts, J.L. (1980).Proc. Natl. Acad. Sci. U.S.A. 77:5211–5215.

    Google Scholar 

  15. Shows, T.B. (1977). InIsozymes: Current Topics in Biological and Medical Research, vol. 2, Rattazzi, M.C., Scandalios, J.G., and Whitt, G.S. (eds). (Alan R. Liss, New York), pp. 107–158.

    Google Scholar 

  16. Shows, T.B., Brown, J.A., Eddy, R.L., Byers, M.G., Haley, L.L., Cooper, E.S., and Goggin, A.P. (1978)Hum. Genet. 43:119–125.

    Google Scholar 

  17. Owerbach, D., Bell, G.I., Rutter, W.J., and Shows, T.B. (1980).Nature 286:82–84.

    Google Scholar 

  18. Owerbach, D., Rutter, W.J., Martial, J.A., Baxter, J.D., and Shows, T.B. (1980).Science 209:289–292.

    Google Scholar 

  19. Naylor, S.L., Byers, M.G., Haley, L.L., Eddy, R.L., Shaver, D., Brown, J.A., and Shows, T.B. (1979).Cytogenet. Cell Genet. 25:190 (abstract).

    Google Scholar 

  20. Shows, T.B., and Brown, J.A. (1975).Proc. Natl. Acad. Sci. U.S.A. 72:2125–2129.

    Google Scholar 

  21. Champion, M.J., Brown, J.A., and Shows, T.B. (1978).Cytogenet. Cell Genet. 22:498–502.

    Google Scholar 

  22. Shows, T.B., Brown, J.A., Haley, L.L., Byers, M.G., Eddy, R.L., Cooper, E.S., and Goggin, A.P. (1978).Cytogenet. Cell Genet. 21:99–104.

    Google Scholar 

  23. Owerbach, D., Bell, G.I. Rutter, W.J., Brown, J.A., and Shows, T.B. (1981).Diabetes 30:267–270.

    Google Scholar 

  24. Shows, T.B. (1972).Proc. Natl. Acad. Sci. U.S.A. 69:348–352.

    Google Scholar 

  25. Klebe, R.J., Chen, T.R., and Ruddle, F.H. (1970).J. Cell Biol. 45:74–82.

    Google Scholar 

  26. Lalley, P.A., Brown, J.A., Eddy, R.L., Haley, L.L., Byers, M.G., Goggin, A., and Shows, T.B. (1977).Biochem. Genet. 15:367–382.

    Google Scholar 

  27. Shows, T.B., Scrafford-Wolff, L., Brown, J.A., and Meisler, M.H. (1979).Somat. Cell Genet. 5:147–158.

    Google Scholar 

  28. Southern, E.M. (1975).J. Mol. Biol. 98:503–517.

    Google Scholar 

  29. Seeburg, P.H., Whitfeld, P., and Shine, J. (in preparation).

  30. Rigby, P.W.J., Dieckmann, M., Rhodes, C., and Berg, P. (1977).J. Mol. Biol. 113:237–251.

    Google Scholar 

  31. Shows, T.B. (1972).Biochem. Genet. 7:193–204.

    Google Scholar 

  32. Shows, T.B., and Brown, J.A. (1975).Cytogenet. Cell Genet. 14:251–255.

    Google Scholar 

  33. Shows, T.B., and McAlpine, P. (1979).Cytogenet. Cell Genet. 25:117–127.

    Google Scholar 

  34. Naylor, S.L., Klebe, R.J., and Shows, T.B. (1978).Proc. Natl. Acad. Sci. U.S.A. 75:6159–6162.

    Google Scholar 

  35. Bootsma, D., and McAlpine, J.P. (1979).Cytogenet. Cell Genet. 25:21–31.

    Google Scholar 

  36. Owerbach, D., Rutter, W.J., Cooke, N.E., Martial, J.A., and Shows, T.B. (1981).Science (in press).

  37. ISCN An International System for Human Cytogenetic Nomenclature (1978).Cytogenet. Cell Genet. 21:313–404.

    Google Scholar 

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Author notes

  1. David Owerbach

    Present address: Hagedorn Research Laboratory, Niels Steensensvej 6, DK-2820, Gentofte, Denmark

Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of California, 94143, San Francisco, California

    David Owerbach & William J. Rutter

  2. Department of Biochemistry, Center for Reproductive Sciences, Columbia University, 10032, New York, New York

    James L. Roberts

  3. Department of Genetics, Research School of Biological Sciences, Australian National University, 2601, Canberra City, A.C.T., Australia

    Peter Whitfeld & John Shine

  4. Genentech, Inc., 460 Point San Bruno Blvd., 94080, South San Francisco, California

    Peter H. Seeburg

  5. Department of Genetics, Roswell Park Memorial Institute New York State Department of Health, 14263, Buffalo, New York

    Thomas B. Shows

Authors
  1. David Owerbach
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  2. William J. Rutter
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  3. James L. Roberts
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  4. Peter Whitfeld
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  5. John Shine
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  6. Peter H. Seeburg
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  7. Thomas B. Shows
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Owerbach, D., Rutter, W.J., Roberts, J.L. et al. The proopiocortin (adrenocorticotropin/β-lipotropin) gene is located on chromosome 2 in humans. Somat Cell Mol Genet 7, 359–369 (1981). https://doi.org/10.1007/BF01538860

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  • DOI: https://doi.org/10.1007/BF01538860

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