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Epidermal growth factor receptor overexpression and trisomy 7 in a case of Barrett's esophagus

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Abstract

Increased expression of epidermal growth factor receptor linked with abnormalities of chromosome 7 has been described in a number of malignancies, but not in premalignant lesions. We report on one patient of nine studied with Barrett's esophagus who had trisomy 7 and showed increased expression of epidermal growth factor receptor. Southern blot analysis demonstrated that the protooncogene c-erb-B, which encodes the epidermal growth factor receptor, was not amplified. However, increased expression of the corresponding mRNA was evident on dot blot analysis. Epidermal growth factor (EGF) binding studies were consistent with increased expression of the receptor with approximately 2.3×105 molecules of EGF bound per cell. These data suggest that chromosome 7 abnormalities can occur in Barrett's esophagus.

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Authors and Affiliations

  1. Sections of Hematology-Oncology, Gastroenterology, and Endocrinology, Department of Medicine, University of Arizona, Tucson Veteran's Administration Medical Center, and Arizona Cancer Center, USA

    Harinder Garewal MD, PhD, Paul Meltzer MD, PhD, Jeffrey Trent PhD, Rao Prabhala MS, Richard Sampliner MD & Murray Korc MD

  2. Departments of Radiation Oncology and Pediatrics, University of Arizona, Tucson Veteran's Administration Medical Center, and Arizona Cancer Center, USA

    Harinder Garewal MD, PhD, Paul Meltzer MD, PhD, Jeffrey Trent PhD, Rao Prabhala MS, Richard Sampliner MD & Murray Korc MD

Authors
  1. Harinder Garewal MD, PhD
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  2. Paul Meltzer MD, PhD
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  3. Jeffrey Trent PhD
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  4. Rao Prabhala MS
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  5. Richard Sampliner MD
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  6. Murray Korc MD
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Additional information

Supported in part by USPHS grant PO1-CA 27502. Harinder Garewal is a recipient of an American Cancer Society Career Development Award.

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Garewal, H., Meltzer, P., Trent, J. et al. Epidermal growth factor receptor overexpression and trisomy 7 in a case of Barrett's esophagus. Digest Dis Sci 35, 1115–1120 (1990). https://doi.org/10.1007/BF01537584

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  • DOI: https://doi.org/10.1007/BF01537584

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