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Amoxycillin/clavulanic acid (augmentin)-induced intrahepatic cholestasis

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Summary

A 75-year-old man developed a biopsy-proven, drug-induced intrahepatic cholestasis after use of amoxycillin trihydrate combined with the Β-lactam inhibitor potassium clavulanate (Augmentin). Cholestatic liver injury is an uncommonly recognized, probably immunologically based adverse reaction to therapy with penicillin and its derivatives.

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Authors and Affiliations

  1. Departments of Gastroenterology, Pathology, Pharmacy and Surgery, University College and Middlesex Hospital Medical School, UK

    J. F. Dowsett MBBS, FRACP, T. Gillow MB, BCh, A. Heagerty MRCP, M. Radcliffe MSC, MPS, R. Toadi MRCP, I. Isle MRCP & R. C. G. Russell FRCS

  2. Department of Medicine, Hertford County Hospital, Herts, UK

    J. F. Dowsett MBBS, FRACP, T. Gillow MB, BCh, A. Heagerty MRCP, M. Radcliffe MSC, MPS, R. Toadi MRCP, I. Isle MRCP & R. C. G. Russell FRCS

Authors
  1. J. F. Dowsett MBBS, FRACP
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  2. T. Gillow MB, BCh
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  3. A. Heagerty MRCP
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  4. M. Radcliffe MSC, MPS
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  5. R. Toadi MRCP
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  6. I. Isle MRCP
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  7. R. C. G. Russell FRCS
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Dowsett, J.F., Gillow, T., Heagerty, A. et al. Amoxycillin/clavulanic acid (augmentin)-induced intrahepatic cholestasis. Digest Dis Sci 34, 1290–1293 (1989). https://doi.org/10.1007/BF01537281

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  • DOI: https://doi.org/10.1007/BF01537281

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