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Case of mixed connective tissue disease associated with autoimmune hepatitis

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Summary

A 56-year-old female with mixed connective tissue disease (MCTD) who developed autoimmune hepatitis is described. Hepatitis was controlled effectively by the corticosteroid therapy. Biopsy of the liver revealed swelling and hydropic degeneration of hepatocytes, accompanied by Councilman's body formation and focal necrosis. These histological findings differ from those in three previously described cases. A relationship between MCTD and liver involvement appears possible.

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Authors and Affiliations

  1. Deparmtent of Internal Medicine, Yokosuka Kyosai Hospital, 1-16 Yonegahamadori-shi, 238, Japan

    Masato Maeda MD,  Masaaki Kanayama MD, Yasushi Hasumura MD, Jugoro Takeuchi MD & Toshikazu Uchida MD

  2. The Second Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo

    Masato Maeda MD,  Masaaki Kanayama MD, Yasushi Hasumura MD, Jugoro Takeuchi MD & Toshikazu Uchida MD

  3. The First Department of Pathology, Nihon University School of Medicine, Tokyo, Japan

    Masato Maeda MD,  Masaaki Kanayama MD, Yasushi Hasumura MD, Jugoro Takeuchi MD & Toshikazu Uchida MD

Authors
  1. Masato Maeda MD
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  2. Masaaki Kanayama MD
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  3. Yasushi Hasumura MD
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  4. Jugoro Takeuchi MD
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  5. Toshikazu Uchida MD
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Maeda, M., Kanayama, M., Hasumura, Y. et al. Case of mixed connective tissue disease associated with autoimmune hepatitis. Digest Dis Sci 33, 1487–1490 (1988). https://doi.org/10.1007/BF01537007

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  • DOI: https://doi.org/10.1007/BF01537007

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