Abstract
In seven beagle dogs with a Thiry-Vella loop, the effect of pacing on small intestinal motor activity was examined by means of extraluminal strain gauge force transducers. Recordings were obtained from the loop and from the remaining small intestine. Our study showed that pacing of the loop results in a significant reduction of the motility of the loop in the overnight fasted state (up to 39%), during loop feeding (up to 55%), and oral feeding (up to 39%); a similar reduction of the motility of the remaining small intestine (up to 43%); and a significant postprandial increase of insulin (9.0 μU/ml) and decrease of glucagon (94 pg/ml). The motility reduction of the loop and of the remaining small intestine as well as the anabolically improved pancreatic endocrine function (shown by an increase of the insulin — glucagon ratio) suggests that this form of pacing could be of benefit for motility disorders with decreased transit time.
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References
Collin J, Kelly KA, Phillips SF: Increased canine jejunal absorption of water, glucose, and sodium with intestinal pacing. Dig Dis 23:1121–1124, 1978
Gladen HE, Kelly KA: Electrical pacing for short bowel syndrome. Surg Gynecol Obstet 153:697–700, 1981
Layzell T, Collin J: Retrograde electrical pacing of the small intestine—a new treatment for the short bowel syndrome? Br J Surg 68:711–713, 1981
Sarr MG, Kelly KA, Gladen HE: Electrical control of canine jejunal propulsion. Am J Physiol 240:G355-G360, 1981
Collin J, Kelly KA, Phillips SF: Enhancement of absorption from the intact and transected canine small intestine by electrical pacing. Gastroenterology 76:1422–1428, 1979
Collin J, Kelly KA, Phillips SF: Absorption from the jejunum is increased by forward and backward pacing. Br J Surg 66:489–492, 1979
Reiser SB, Holle GE: Motor and electrical activity of the gastroduodenal junction before and after submucosal pyloroplasty. World J Surg 6:231–235, 1982
Herbert V, Lau KS, Gottlieb CW, Bleicher SJ: Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25:1375–1384, 1965
Faloona GR, Unger HR: Glucagon.In Methods in Hormone Radioimmunoassay. BM Jaffe, MR Behrmann (eds). New York, Academic Press, 1974, pp 317–331
Szurszewski JH: A migrating electric complex of the canine small intestine. Am J Physiol 217:1757–1763, 1969
Layzell T, Collin J, Johnston IDA: Effect of retrograde electrical pacing on jejunal absorption of xylose and vitamin C. J Parenter Enter Nutr 5:103–105, 1981
Gladen HE, Kelly KA: Enhancing absorption in the canine short bowel syndrome by intestinal pacing. Surgery 88:281–286, 1980
Cranley B, Kelly KA: Small intestinal regulation of gastric emptying.In Gastrointestinal Motility. C Roman (ed). Lancaster, MTP Press, 1984, pp 129–140
Cranley B, Kelly KA, Go VLW, McNichols LA: Enhancing the anti-dumping effect of Roux gastrojejunostomy with intestinal pacing. Ann Surg 198:516–524, 1983
Bjorck S, Kelly KA, Phillips SF: Mechanisms of enhanced canine enteric absorption with intestinal pacing. Am J Physiol 252:G548-G553, 1987
Felig P, Wahren J: Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism in man. J Clin Invest 50:1702–1711, 1971
Mackrell DJ, Sokal JE: Antagonism between the effects of insulin and glucagon on the isolated liver. Diabetes 18:724–732, 1969
Unger RH: Glucagon and the insulin:glucagon ratio in diabetes and other catabolic illnesses. Diabetes 20:834–839, 1971
Frohman LA, Ezdinli EZ, Javid R: Effect of vagotomy and vagal stimulation on insulin secretion. Diabetes 16:443–448, 1967
Ionescu E, Rohner-Jeanrenaud F, Berthoud HR, Jeanrenaud B: Increases in plasma insulin levels in response to electrical stimulation of the dorsal motor nucleus of the vagus nerve. Endocrinology 112:904–910, 1983
Kaneto A, Miki E, Kosaka K: Effects of vagal stimulation on glucagon and insulin secretion. Endocrinology 95:1005–1010, 1974
Christofides ND, Modlin IM, Fitzpatrick ML, Bloom SR: Effect of motilin on the rate of gastric emptying and gut hormone release during breakfast. Gastroenterology 76:903–907, 1979
Schusdziarra V, Dangel G, Henrichs I, Klier M, Pfeiffer EF: Rate dependent stimulation of insulin and glucagon but not gastrin and somatostatin release during the intestinal phase of a meal. Horm Metab Res 14:169–171, 1982
Dupré J, Ross SA, Watson D, Brown JC: Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab 37:826–828, 1973
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The present study was supported by Deutsche Forschungsgemeinschaft.
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Reiser, S.B., Weiser, H.F., Schusdziarra, V. et al. Effect of pacing on small intestinal motor activity and hormonal response in dogs. Digest Dis Sci 34, 579–584 (1989). https://doi.org/10.1007/BF01536336
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DOI: https://doi.org/10.1007/BF01536336