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Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation

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Summary

A case of hepatitis B reactivation following bone-marrow transplantation for leukemia in a previously healthy HBsAg carrier is reported. A number of changes in HBV serum markers were contemporary to the acute episode. All of them (increase of HBsAg concentration, conversion from anti-HBe to HBeAg, appearance of anti-HBc IgM, and of serum HBV-DNA) were suggestive of a “switching-on” of viral replication. Institution of corticosteroid treatment at the onset of the acute phase did not prevent the fatal outcome.

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Authors and Affiliations

  1. Unité de recherches de Physiopathologie hépatique, INSERM U22, France

    E. Alexandre Pariente MD, Alain Goudeau MD, Frédéric Dubois MD, Claude Degott MD, Elaine Gluckman MD, Agnès Devergie MD, Christian Brechot MD, Christine Schenmetzler MD & Jacques Bernuau MD

  2. Laboratoire d'Anatomie et de Cytologie pathologiques, Hôpital Beaujon, 92118, Clichy Cedex, France

    E. Alexandre Pariente MD, Alain Goudeau MD, Frédéric Dubois MD, Claude Degott MD, Elaine Gluckman MD, Agnès Devergie MD, Christian Brechot MD, Christine Schenmetzler MD & Jacques Bernuau MD

  3. Laboratoire de Virologie, CHRU Bretonneau, 37044, Tours Cedex, France

    E. Alexandre Pariente MD, Alain Goudeau MD, Frédéric Dubois MD, Claude Degott MD, Elaine Gluckman MD, Agnès Devergie MD, Christian Brechot MD, Christine Schenmetzler MD & Jacques Bernuau MD

  4. Institut de Recherches sur les maladies du sang, Hôpital Saint-Louis, 75010, Paris, France

    E. Alexandre Pariente MD, Alain Goudeau MD, Frédéric Dubois MD, Claude Degott MD, Elaine Gluckman MD, Agnès Devergie MD, Christian Brechot MD, Christine Schenmetzler MD & Jacques Bernuau MD

  5. Unité de recombinaison et expression génétique, INSERM U163, Institut Pasteur, 75015, Paris, France

    E. Alexandre Pariente MD, Alain Goudeau MD, Frédéric Dubois MD, Claude Degott MD, Elaine Gluckman MD, Agnès Devergie MD, Christian Brechot MD, Christine Schenmetzler MD & Jacques Bernuau MD

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  1. E. Alexandre Pariente MD
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  2. Alain Goudeau MD
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  3. Frédéric Dubois MD
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  4. Claude Degott MD
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  5. Elaine Gluckman MD
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  6. Agnès Devergie MD
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  7. Christian Brechot MD
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  8. Christine Schenmetzler MD
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  9. Jacques Bernuau MD
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Pariente, E.A., Goudeau, A., Dubois, F. et al. Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation. Digest Dis Sci 33, 1185–1191 (1988). https://doi.org/10.1007/BF01535798

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  • DOI: https://doi.org/10.1007/BF01535798

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