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Long-range restriction map around 11p13 aniridia locus

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Somatic Cell and Molecular Genetics

Abstract

Using two random DNA markers, and pulsed field gel electrophoresis, a 1.5-Mb physical map surrounding the 11p13 aniridia locus (AN2)has been assembled. The map was constructed using a combination of single- and double-restriction digests on DNA from normal controls and a patient transmitting familial aniridia. The aniridia patient has a chromosome translocation and the two DNA markers flank the breakpoint. This 11p13 breakpoint lies no further than 100 kb from the DNA marker 1104 (D11S95),located on the centromeric side of the breakpoint. Two CpG islands, separated by 550 kb and flanking the translocation, suggest an upper limit to the size of the gene.

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Author notes

  1. Andrew M. Everest

    Present address: Department of Biophysics, Northwestern University, Chicago

Authors and Affiliations

  1. Department of Human Genetics, Roswell Park Memorial Institute Buffalo, 14263, New York

    Lisa M. Davis, Andrew M. Everest & Thomas B. Shows

  2. Department of Medical Genetics, University of Helsinki, Finland

    Kalle O. J. Simola

Authors
  1. Lisa M. Davis
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  2. Andrew M. Everest
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  3. Kalle O. J. Simola
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  4. Thomas B. Shows
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Davis, L.M., Everest, A.M., Simola, K.O.J. et al. Long-range restriction map around 11p13 aniridia locus. Somat Cell Mol Genet 15, 605–615 (1989). https://doi.org/10.1007/BF01534921

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  • DOI: https://doi.org/10.1007/BF01534921

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