Summary
Treatment with the commonly used diuretic, chlorthalidone, has previously been found to increase the serum low-density-lipoprotein cholesterol (LDL-C) fraction. Therefore, the effects of two new agents, tienilic acid (a combined diuretic-uricosuric) and indapamide on serum lipid and lipoprotein levels were assessed. Six weeks of treatment with tienilic acid, 250 mg/day, markedly decreased serum uric acid and significantly increased LDL-C and triglycerides in 16 men. In contrast, indapamide 2.5 mg/day, had no apparent influence on serum lipids or lipoproteins in 18 men.
Zusammenfassung
In einer früheren Studie fanden wir, daß eine Kurzzeitbehandlung mit dem Diuretikum Chlorthalidon eine Erhöhung der Serum Low-Density-Lipoprotein-Cholesterin Fraktion (LDL-C) bewirkt. In der vorliegenden Arbeit wurde der Einfluß von zwei neueren Substanzen auf die Serum Lipidund Lipoprotein-Spiegel untersucht. Dabei handelte es sich um Tienilsäure, das gleichzeitig diuretische und uricosurische Wirksamkeit besitzt, sowie um Indapamid. Eine 6-wöchige Behandlung mit Tienilsäure in einer Dosis von 250 mg/Tag bewirkte bei 16 Männern eine deutliche Abnahme der Serum-Harnsäure und eine signifikante Zunahme von LDL-C und Serum-Triglyzeriden. Dagegen hatte eine gleichlange Behandlung mit Indapamid in einer Dosis von 2,5 mg/Tag bei 18 Männern keinen erkennbaren Einfluß auf Serum-Lipide oder -Lipoproteine.
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References
Ames RP, Hill P (1976) Elevation of serum lipid levels during diuretic therapy of hypertension. Am J Med 61:748–757
Carvalho JGR, Dunn FG, Chrysant SG, Frohlich ED (1978) Ticrynafen: a novel uricosuric antihypertensive natriuretic agent. Arch Int Med 138:53–57
Castelli WP, Doyle JT, Gordon T, Hames CG, Hjortland MC, Hulley SB, Kagan A, Zukel WJ (1977) HDL cholesterol and other lipids in coronary heart disease. Circulation 55:767–772
Frohlich ED (1979) Ticrynafen: a new thiazide-like but uricosuric antihypertensive diuretic. N Engl J Med 301:1378–1382
Glück Z, Baumgartner G, Weidmann P, Peheim E, Bachmann C, Mordasini R, Flammer J, Keusch G (1978) Increased ratio between serum β- and α-lipoproteins during diuretic therapy: an adverse effect? Clin Sci Mol Med 55:325 s-328 s
Glück Z, Weidmann P, Mordasini R, Bachmann C, Riesen W, Peheim E, Keusch G, Meier A (1980) Increased serum low-density-lipoprotein cholesterol in men treated short-term with the diuretic chlorthalidone. Metabolism 29:240–245
Joos C, Kewitz H, Reinhold-Kourniati D (1980) Effects of diuretics on plasma lipoproteins in healthy men. Eur J Clin Pharmacol 17:251–258
Mancini G, Vaertmann JP, Carbonara AO, et al (1965) Immunochemic quantitation of antigen by single radial immunodiffusion. Immunochemistry 2:235–237
Mironneau J, Gargouil YM (1977) Actions de l'indapamide sur la musculature lisse. Rev Médicine 18:1587–1590
Mordasini R, Frey F, Flury W, Klose G, Greten H (1977) Selective deficiency of hepatic triglyceride lipase in uremic patients. N Engl J Med 297:1362–1366
Mudge GH (1975) Diuretics and other agents employed in the mobilisation of edema fluid. In: Goodman ES, Gilman A (eds). The Pharmacological basis of therapeutics, 5th edition Macmillan Publishing Co, New York, pp 817–847
Schnaper H, Fits A, Frohlich E, Goldman A, Perry HM, Steele B (1977) Chlorthalidone and serum cholesterol. Lancet 2:295
Snow IB, Maass AR (1979) Renal sites of natriuretic and uricosuric activity of ticrynafen in the mongrel dog. Nephron 23 [Suppl 1]:15–20
Stone NJ, Levy RI, Fredrickson DS, Verter J (1974) Coronary artery disease in 116 kindred with familial type II hyperlipoproteinemia. Circulation 49:476–488
Weidmann P, Hirsch D, Beretta-Piccoli C, Reubi FC, Ziegler WH (1977) Interrelations among blood pressure, blood volume, plasma renin activity, and urinary catecholamines in benign essential hypertension. Am J Med 62:209–218
Weidmann P, Keusch G, Meier A, Glück Z, Grimm M, Beretta-Piccoli C (1980) Effects of indapamide on the body sodium-volume state, plasma renin, aldosterone and catecholamines, and cardiovascular pressor sensitivity in normal and borderline hypertensive man. Excerpta Medica, Int Congress Series 496:169–181
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Supported in part by the Swiss National Science Foundation
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Weidmann, P., Meier, A., Mordasini, R. et al. Diuretic treatment and serum lipoproteins: Effects of tienilic acid and indapamide. Klin Wochenschr 59, 343–346 (1981). https://doi.org/10.1007/BF01525002
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DOI: https://doi.org/10.1007/BF01525002