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Mechanism of hemolysis by anionic surface-active agents

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Summary

A study is made of the mechanism of hemolysis by anionic surface-active agents. It is supposed that the primary site of the hemolytic attack by anionic agents is the protein moiety of the red cell membrane at physiological pH. The role of phospholipid release in hemolysis increases as the PH of the medium decreases.

Zusammenfassung

Der Mechanismus der Hämolyse durch anionische oberflächenaktive Agentien wurde untersucht. Es ist anzunehmen, daß primär der hämolytische Angriff durch anionische Agentien beim physiologischen PH am Proteinteil der Erythrozyt-Membran zu suchen ist. Mit der Abnahme des PH des Mediums spielt die Phospholipid-Freistellung bei der Hämolyse eine immer größere Rolle.

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Author notes

  1. M. Tomizawa & T. Kondo

    Present address: Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan

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    1. M. Tomizawa
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    2. T. Kondo
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    Tomizawa, M., Kondo, T. Mechanism of hemolysis by anionic surface-active agents. Kolloid-Z.u.Z.Polymere 246, 694–699 (1971). https://doi.org/10.1007/BF01501304

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    • DOI: https://doi.org/10.1007/BF01501304

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