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Osteopathy in experimental uremia

I. Vitamin D-Resistance

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Summary

The O2 dependent calcium accumulation in duodenal mucosa and the width of the zone of provisional calcification of tibiae (line test) were measured in rachitic rats with renal insufficiency after an oral dose of vitamin D2. As shown by the lodgose response curves, vitamin D produced a diminished response (vitamin D refractoriness) at all dose levels tested. Diminished remineralisation of the skeleton in renal insufficiency (both provisional calcification of cartilage and mineralisation of osteoid) was not due to decreased intestinal calcium absorption and was even observed in the presence of hypercalcaemia.

Zusammenfassung

Bei rachitischen, niereninsuffizienten Ratten wurde die O2-abhängige Calcium-Akkumulation in der Duodenalmucosa und die Breite der primären Verkalkungszone der Tibiaepiphyse (Line-Test) nach peroraler Gabe von Vitamin D2 gemessen. Ein vermindertes Ansprechen auf Vitamin D (Vitamin D-Resistenz) bei Niereninsuffizienz konnte durch Aufstellen der Dosiswirkungskurve nachgewiesen werden. Die verminderte Remineralisation des urämischen Skelets (primäre Verkalkung des Epiphysenknorpels und Mineralisation des Osteoids) war nicht die Folge des verminderten intestinalen Calcium-Transportes, da sie auch bei hungernden Tieren auftrat; desgleichen konnte eine verminderte Mineralisation des urämischen Skelets selbst bei Vorliegen einer Hypercalcämie noch nachgewiesen werden.

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Authors and Affiliations

  1. Medizinische Universitätsklinik Heidelberg und Pathologisches Institut der Universität Heidelberg, Germany

    E. Ritz, B. Krempien, H. Kütemeyer & K. Andrassy

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  1. E. Ritz
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  2. B. Krempien
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  3. H. Kütemeyer
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  4. K. Andrassy
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Ritz, E., Krempien, B., Kütemeyer, H. et al. Osteopathy in experimental uremia. Klin Wochenschr 49, 113–115 (1971). https://doi.org/10.1007/BF01497312

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