Summary
Serum lysozyme (muramidase) concentrations were determined in five patients with Morbus Crohn before and after resection of inflammated bowel areas. The serum lysozyme activity which was elevated before surgical treatment in all patients fell to normal values after bowel resection within a few hours. Our findings suggest, that the elevated serum lysozyme reflects an increased lysozyme production in the inflammated bowel tissue.
Zusammenfassung
Bei fünf Patienten mit M. Crohn wurde vor und nach Resektion entzündeter Darmbezirke Serumlysozym (Muramidase) bestimmt. Präoperativ deutlich erhöhte Lysozymkonzentrationen fallen postoperativ innerhalb weniger Stunden zur Norm ab. Die Vermutung, daß die granulomatös veränderten Darmanteile Produktionsort des erhöhten Serumlysozyms sind, wird damit gestützt.
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Pott, G., Schmidt, A., Buddecke, E. et al. Serumlysozym-Konzentrationen bei Patienten Mit Morbus Crohn vor und nach Darmresektion. Klin Wochenschr 55, 557–558 (1977). https://doi.org/10.1007/BF01489352
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DOI: https://doi.org/10.1007/BF01489352