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Untersuchungen über die Serum-Angiotensinase

II. Mitteilung Klinische Ergebnisse beim Hochdruck und bei Lebererkrankungen

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Zusammenfassung

Unsere Untersuchungen bei 320 Gesunden und Kranken zeigen, daß die Serum-Angiotensinase bei der essentiellen und renalen Hypertonie im Normbereich, bei Patienten mit akuter Hepatitis, Lebercirrhosen und Verschlußikterus auf das 2–5fache der Norm erhöht ist. Es wird diskutiert, ob der klinisch schon lange bekannte Blutdruckabfall bei Lebererkrankungen ursächlich durch diesen Antiseg der Serum-Angiotensinase bedingt ist. Beim Hochdruck steht einer wahrscheinlich gesteigerten Reninausschüttung und Angiotensinproduktion eine normale Serum-Angiotensinase gegenüber, so daß möglicherweise für die Pathogenese der Blutdrucksteigerung eine relative Verminderung der Serum-Angiotensinase bedeutsam ist.

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Literatur

  1. Biron, P., E. Koiw, W. Nowaczynski, J. Brouillet andJ. Genest: The effects of intravenous infusions of valine-5-angiotensin II and other pressor agents on urinary electrolyte and corticosteroids including aldosterone. J. clin. Invest.40, 338 (1961).

    Google Scholar 

  2. Bisset, G. W.: Effect of tyrosinase preparations on oxytocin, vasopressin and bradykinin. Brit. J. Pharmacol.18, 405 (1962).

    Google Scholar 

  3. Braun-Menendez, E., J. C. Fasciolo, L. F. Leloir, J. M. Munoz andA. C. Taquini: Renal hypertension. Springfield (Ill.): Ch. C. Thomas 1946.

    Google Scholar 

  4. Bumpus, F. M., P. A. Khairallah, K. Arakawa, J. H. Page andR. R. Smeby: The relationship of structure to pressor and oxytoxic actions of isoleucine angiotensin octapeptid and various analogues. Biochim. Biophys. Acta46, 38 (1961).

    Google Scholar 

  5. Bumpus, F. M., H. Schwarz andJ. H. Page: Synthesis and pharmacology of the octapeptide angiotonin. Science125, 886 (1957).

    Google Scholar 

  6. Chauffard, J.:.

    Google Scholar 

  7. Davis, J. O., C. J. Carpenter, C. R. Ayers, J. E. Holman andR. C. Bahn: Relation of renin angiotensin II and experimental renal hypertension to aldosterone secretion. J. clin. Invest.40, 2026 (1961).

    Google Scholar 

  8. Davis, J. O., P. M. Hartroft, E. O. Titus, C. J. Carpenter, C. R. Ayers andE. H. Spiegel: The role of the renin-angiotensin system in the control of aldosterone secretion. J. clin. Invest.41, 378 (1962).

    Google Scholar 

  9. Dexter, L.: The hypertensinase content of plasma of normal, hypertensive and nephrectomized dogs. Ann. intern. Med.17, 447 (1942).

    Google Scholar 

  10. Dexter, L., andF. W. Haynes: Relation of renin to human hypertension with particular reference to eclampsia, preeclampsia and acute glomerulo-nephritis. Proc. Soc. exp. Biol. (N.Y.)55, 288 (1944).

    Google Scholar 

  11. Elliot, D. F., andW. S. Peart: The aminoacid sequence in a hypertensin. Biochem. J.65, 246 (1957).

    Google Scholar 

  12. Elliot, D. F., andW. S. Peart: Amino acid sequence in a hypertensin. Nature (Lond.)177, 257 (1956).

    Google Scholar 

  13. Folk, J. E., andJ. A. Gladner: Carboxypeptidase B. J. biol. Chem.231, 379 (1958).

    Google Scholar 

  14. Ganong, W. F., andP. J. Mulrow: Evidence of secretion of an aldosterone-stimulating substance by the kidney. Nature (Lond.)190, 1115 (1961).

    Google Scholar 

  15. Gelander, P.: Epidemischer und sporadischer Ikterus. Acta paediat. (Uppsala), Suppl.4, 23 (1939).

    Google Scholar 

  16. Genest, J., P. Biron, E. Koiw, W. Nowaczynski, R. Boucher andM. Chrétien: Studies of the pathogenesis of human hypertension. Ann. intern. Med.55, 12 (1961).

    Google Scholar 

  17. Gilbert u.Garnier:.

    Google Scholar 

  18. Glenner, G. G., P. J. McMillan andJ. E. Folk: A mammalian peptidase spezific for the hydrolysis of N-terminal α-l-glutamyl and aspartyl residues. Nature (Lond.)194, 876 (1962).

    Google Scholar 

  19. Goldbarg, J. A., andA. M. Rutenburg: The colorimetric determination of leucine aminopeptidase in urine and serum of normal subjects and patients with cancer and other diseases. Cancer, N. Y.11, 283 (1958).

    Google Scholar 

  20. Gollan, F., E. Richardson andH. Goldblatt: Hypertensin in the systemic blood of animal with experimental renal hypertension. J. exp. Med.88, 389 (1948).

    Google Scholar 

  21. Greenspan, F. S., Ch. H. Li andH. M. Evans: Disappearance rate of adrenocorticotropin hormone from rats plasma after intravenous injection. Endocrinology46, 261 (1950).

    Google Scholar 

  22. Grollmann, A., E. E. Muirhead andJ. Vanatta: Role of the kidney in pathogenesis of hypertension. Amer. J. Physiol.157, 21 (1949).

    Google Scholar 

  23. Gross, F.: Renin und Hypertensin. Klin. Wschr.36, 693 (1958).

    Google Scholar 

  24. Gross, F., u.F. Sulzer: Pressorische Substanzen in den Nieren experimentell hypertonischer Ratten. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak.229, 375 (1956).

    Google Scholar 

  25. Gross, F., andH. Turrian: Pharmacology of hypertensin and synthetic analogues; In:M. Schachter, Polypeptides, p. 137. London: Pergamon Press 1960.

    Google Scholar 

  26. Gross, F., K. D. Bock u.H. Turrian: Untersuchungen über die Blutdruckwirkung von Angiotensin. Helv. physiol. pharmacol. Acta19, 42 (1961).

    Google Scholar 

  27. Haas, E., andH. Goldblatt: Renin content of kidneys in experimental renal and human essential hypertension. Amer. J. Physiol.197, 1103 (1959).

    Google Scholar 

  28. Harakal, C. D., andD. A. Collins: Plasma hypertensinase in experimental renal hypertension. Circulat. Res.4, 612 (1956).

    Google Scholar 

  29. Haynes, F. W., andL. Dexter: The hypertensinogen concentration of the plasma of patients with various diseases. Fed. Proc.2, 20 (1943).

    Google Scholar 

  30. Haynes, F. W., andL. Dexter: Plasma hypertensinase. J. clin. Invest.24, 75 (1945).

    Google Scholar 

  31. Helmer, O.: Presence of renin in plasma of patients with arterial hypertension. Circulation25, 169 (1962).

    Google Scholar 

  32. Helmer, O., K. G. Kohlstaedt, G. F. Kempf andJ. H. Page: The assay of anti-pressor extracts of kidney by in vitro destruction of angiotonin. Fed. Proc.1, 114 (1942).

    Google Scholar 

  33. Kahn, J. R., L. T. Skeggs, N. P. Shumway andP. E. Wisenbaugh: The assay of hypertensin from the arteria blood of normotensive and hypertensive human beings. J. exp. Med.95, 523 (1952).

    Google Scholar 

  34. Kaplan, N. M., andF. C. Bartter: The effect of ACTH, renin, angiotensin II and various precursors on biosynthesis of aldosterone by adrenal slices. J. clin. Invest.41, 715 (1962).

    Google Scholar 

  35. Klaus, D.: Aminopeptidasen im menschlichen Organismus. Ärztl. Forsch.15, 548 (1961).

    Google Scholar 

  36. Klaus, D.: Untersuchungen über die Angiotensinase im Serum Gesunder und Kranker. Klin. Wschr.40, 701 (1962).

    Google Scholar 

  37. Laragh, J. H.: Interrelationship between angiotensin, norepinephrine, epinephrine, aldosterone secretion and electrolyte metabolism in man. Circulation25, 203 (1962).

    Google Scholar 

  38. Laragh, J. H., S. Ulick, V. Januszewicz, Q. B. Deming, W. G. Kelly andS. Liebermann: Aldosterone secretion and primary and malignant hypertension. J. clin. Invest.39, 1091 (1960).

    Google Scholar 

  39. Laragh, J. H., M. Angers, W. G. Kelly andS. Liebermann: Hypotensive agents and pressor substances. The effect of epinephrine, norepinephrine, angiotensin II and others on the secretory rate of aldosterone in man. J. Amer. med. Ass.174, 234 (1960).

    Google Scholar 

  40. Lentz, K. E., L. T. Skeggs, K. R. Woods, J. R. Kahn andN. P. Shumway: The amino acid composition of hypertensin II and its biochemical relationship to hypertensin I. J. exp. Med.104, 183 (1956).

    Google Scholar 

  41. Maschmann, E.: Zur Kenntnis tierischer Peptidasen. Biochem. Z.310, 28 (1941).

    Google Scholar 

  42. Meakins, J. C.: Jaundice and blood pressure. Med. Clin. N. Amer.16, 715 (1932).

    Google Scholar 

  43. Mendlowitz, M., H. L. Weinreb, N. Naftchi andS. E. Gitlow: Further observations supporting the enzyme deficit theory of the cause of essential hypertension. Circulation20, 740 (1959).

    Google Scholar 

  44. Mulrow, P. J., W. F. Ganong, G. Cera andA. Kuljian: The nature of the aldosterone-stimulating factor on dog kidneys. J. klin. Invest.41, 505 (1962).

    Google Scholar 

  45. Munoz, J. W., E. Braun-Menendez, J. C. Fasciolo andL. F. Leloir: The mechanism of renal hypertension. Amer. J. med. Sci.200, 608 (1940).

    Google Scholar 

  46. Nachlas, M. M., Th. P. Goldstein andA. M. Seligman: An evaluation of aminopeptidase specifity with seven chromogenic substrates. Arch. Biochem.97, 223 (1962).

    Google Scholar 

  47. Page, J. H.: In: Essentielle Hypertonie, herausgeg. v.K. D. Bock u.P. Cottier. Berlin-Göttingen-Heidelberg: Springer 1960.

    Google Scholar 

  48. Page, J. H., andF. Olmsted: Hemodynamic effects of angiotensin, norepinephrine and bradykinin continuously measured in unaesthetized dogs. Amer. J. Physiol.201, 92 (1961).

    Google Scholar 

  49. Peart, W. S.: Angiotensin in experimental and clinical hypertension. In:M. Schachter, Polypeptides, p. 122

    Google Scholar 

  50. Raaschou, Fl.: Liver function and hypertension. Circulation10, 511 (1954).

    Google Scholar 

  51. Raaschou, Fl., andK. Trautner: Obstruction of the common bile duct in experimental renal hypertension in dogs. Scand. J. clin. Lab. Invest.5, 223 (1953).

    Google Scholar 

  52. Sanger, F., andH. Tuppy: The amino-acid sequence in the phenylalanyl chain of insulin. Biochem. J.49, 463 (1951).

    Google Scholar 

  53. Sapirstein, L. A., K. R. Reed andE. W. Page: The site of angiotonin destruction. J. exp. Med.83, 425 (1946).

    Google Scholar 

  54. Schroeder, H. A.: The effect of 1-Hydrazinophthalazine in hypertension. Circulation5, 28 (1952).

    Google Scholar 

  55. Schwyzer, R.: Preparations of analogues of hypertensin II. In:M. Schachter, p. 152

    Google Scholar 

  56. Schwyzer, R.: Diskussionsbemerkung inSchachter, S. 160. (s. 25).

  57. Shepard, R. G., S. D. Wilson, K. S. Howard, P. H. Bell, D. S. Davies, S. B. Davies, E. A. Eigner andN. E. Shakespeare: Studies with corticotropin. J. Amer. chem. Soc.78, 5067 (1956).

    Google Scholar 

  58. Skeggs, L. T., J. B. Kahn andN. P. Shumway: The preparation and function of the hypertensin converting enzyme. J. exp. Med.103, 295 (1956).

    Google Scholar 

  59. Spatt, S. D., andP. Rosenblatt: The incidence of hypertension in portal cirrhosis. Ann. intern. Med.31, 479 (1949).

    Google Scholar 

  60. Taquini, A. C., andJ. C. F. Fasciolo: Dosage of circulating renin in arterial hypertension. Rev. argent. Cardiol.14, 1 (1947).

    Google Scholar 

  61. Tuppy, H., u.H. Nesvadba: Über die Aminopeptidaseaktivität des Schwangerenserums und ihre Beziehung zu dessen Vermögen Oxytocin zu inaktivieren. Mh. Chem. (Wien)88, 977 (1957).

    Google Scholar 

  62. Wolf, R. L., M. Mendlowitz, S. E. Gitlow andN. Naftchi: Metabolism of angiotensin II–I131 in normotensive and hypertensive human subjects. Circulation23, 754 (1961).

    Google Scholar 

  63. Wolf, L. R., M. Mendlowitz, J. Pick, S. E. Gitlow andN. Naftchi: In vitro degradation of I131 labeled angiotensin II by normotensive and hypertensive human serum. Proc. Soc. exp. Biol. (N.Y.)109, 308 (1962).

    Google Scholar 

  64. Wollheim, E., u.J. Moeller: Hypertonie und Hypotonie. In: Handbuch der inn. Med., Bd. IX/5. Berlin-Göttingen-Heidelberg: Springer 1960.

    Google Scholar 

  65. Wood, J. E.: Genetic control of neutralization of angiotensin and its relationship to essential hypertension. Circulation25, 225 (1962).

    Google Scholar 

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  1. Aus der Medizinischen Universitäts-Poliklinik Tübingen, Germany

    D. Klaus, H. Kaffarnik & H. Pfeil

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  2. H. Kaffarnik
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  3. H. Pfeil
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Klaus, D., Kaffarnik, H. & Pfeil, H. Untersuchungen über die Serum-Angiotensinase. Klin Wochenschr 41, 380–385 (1963). https://doi.org/10.1007/BF01487867

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