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Malignant hyperthermia syndrome—Evidence for denervation changes in human skeletal muscle

Syndrom der Malignen Hyperthermie: Hinweise auf Denervationsveränderungen im menschlichen Skeletmuskel

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Zusammenfassung

Bei Personen, welche zur malignen Hyperthermii disponiert sind, legen denervationsähnliche Veränderungen und abnorme Mitochondrien eine neuropathische Basis des Syndroms nahe. Möglicherweise stellt ein Defekt in der mitochondrialen ATP-Synthese, der auf einer Denervation beruht und durch einige Anaesthetika potenzient wird, die primäre Lasion der Muskelfaser beim Syndrom der malignen Hyperthermie Menschen dar.

Summary

The presence of denervation-like changes and abnormal mitochondria in the muscle of carriers of the malignant hyperthermia syndrome suggest a neuropathic basis for the human syndrome. A defect in mitochondrial ATP synthesis resulting from denervation, and potentiated by some general anaesthetics, may be the primary muscle fibre lesion in the human malignant hyperthermic syndrome.

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Authors and Affiliations

  1. Neuromuscular Research Laboratory, Medical School, University of the Witwatersrand, Johannesburg, South Africa

    J. J. A. Heffron & H. Isaacs

  2. Department of Anaesthesiology Mayo Clinic, 55901, Rochester, Minnesota, U.S.A.

    J. J. A. Heffron

Authors
  1. J. J. A. Heffron
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  2. H. Isaacs
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Heffron, J.J.A., Isaacs, H. Malignant hyperthermia syndrome—Evidence for denervation changes in human skeletal muscle. Klin Wochenschr 54, 865–867 (1976). https://doi.org/10.1007/BF01483587

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  • DOI: https://doi.org/10.1007/BF01483587

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