Zusammenfassung
Bei 78 von 4120 Seren von Personen mit überstandener Syphilis wurde mit Hilfe der Gel-Filtration an Sephadex G 200 bzw. Sucrosegradienten der Ultrazentrifuge ein treponema-spezifischer niedermolekularer (8S) IgM-Antikörper isoliert. Die IgM-Spezifität wird in der indirekten Immunfluoreszenz unter Verwendung eines ώ-kettenspezifischen Antiserums nachgewiesen. Diese niedermolekularen IgM (LMW-IgM)-Antikörper sind aufgrund der Untersuchungen durch Gel-Filtration und Sucrosegradienten mit dem 19S-IgM nicht identisch. Es besteht auch keine Identität mit 7S-IgG oder IgA. In der LMW-IgM-Fraktion konnte weder ein antinukleärer Faktor noch ein Rheumafaktor nachgewiesen werden. Bei den meisten Patienten mit LMW-IgM-Antikörper lag eine Treponema-Infektion in der Spätlatenz vor.
Summary
A low-molecular (8S) treponema-specific IgM antibody was isolated by means of Sephadex 200 G gel filtration and/or sucrose gradient ultracentrifugation in 78 of 4,120 sera of patients who had been identified to have had syphilis. The IgM specificity can be shown by indirect immunofluorescence using a ώ-chain specific antiserum. The low molecular IgM (LMW-IgM) antibodies are not identical with the 19S-IgM as demonstrated in studies with gel filtration and sucrose gradient methods. They are not identical neither with 7S IgG or IgA. Neither the presence of antinuclear nor rheumatic factor could be shown in the LMW-IgM fraction. In most of the patients with LMW-IgM antibody, there existed a treponema infection of late latency.
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Müller, F., Oelerich, S. Identification of a low molecular weight IgM antibody with treponema pallidum specificity in sera of patients with chronic syphilis. Klin Wochenschr 57, 667–671 (1979). https://doi.org/10.1007/BF01477667
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DOI: https://doi.org/10.1007/BF01477667