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Bedeutung von Fc-IgG und Fc-IgM Rezeptoren auf menschlichen T-Lymphozyten

The significance of Fc-IgG and Fc-IgM receptors on human T-lymphocytes

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Summary

About 15–20% of human circulating T-cells express Fc-IgG receptors (TG cells), and about 70–80% have Fc-IgM receptors (TM cells). TM cell express Fc-IgG receptors (TG cells), and about 70–80% have Fc-IgM receptors (TM cells). TM cell enriched fractions are functionally heterogenous cell populations. TM cells are able to mature into specific cytotoxic T-cells after mixed lymphocyte reaction; TM cell fractions also comprise the helper T-cells for poke-weed mitogen (PWM) induced B cell differentiation; and some TM cells can be induced to act suppressively on PWM induced B-cell differentiation and maturation. TG cells represent activated, relatively radiation resistant suppressor T-cells, and these cells are also active in natural cytotoxicity (NC), antibody dependent cellular cytotoxicity (ADCC) and mitogen induced cellular cytotoxicity (MICC). IgG-immune-complex interaction with the Fc-IgG receptor on TG cells modulates Fc-receptor expression as it leads to loss of Fc-IgG receptors and expression of Fc-IgM receptors on the original TG cells after culture. This modulation of surface markers is accompagnied by functional changes since ADCC and suppressor cell activity is recuced following immunecomplex interaction. Fc-IgG and Fc-IgM receptor expression on human T cells seems therefore to characterize distinct functional stages of T cells. IgG immunecomplex interaction in vitro seems to be a potent tool to change the different functional stages.

Zusammenfassung

Menschliche T-Lymphozyten exprimieren zu 15–20% Fc-IgG Rezeptoren (TG-Zellen) und zu 70–80% Fc-IgM Rezeptoren (TM-Zellen). TM-Zell angereicherte Fraktionen beinhalten funktionell unterschiedliche T-Zellen. TM-Zellen sind fähig in der gemischten Lymphozytenkultur zu Effektorzellen der spezifischen T-Zell vermittelten Zytotoxizität zu reifen. Weiters sind Fc-IgM Rezeptor tragende T-Zellen Helfer-T-Zellen für die |DdPokeweed-Mitogen|DD induzierte B-Zell-Reifung, und neuere Untersuchungen konnten zeigen, daß ein Teil der TM-Zellen zu Suppressorzellen stimuliert werden kann. Fc-IgG rezeptor tragende Zellen sind aktivierte Suppressor-Zellen und sind aktiv in “Natural Cytotoxicity”, Antikörper vermittelter Zytotoxizität und Mitogen induzierter Zytotoxizität. IgG-Immunkomplexkontakt mit dem Fc-IgG Rezeptor auf TG-Zellen moduliert die Fc-Rezeptoren, indem Immunkomplexkontakt den Verlust des Fc-IgG-Rezeptors induziert und es nach 20stündiger in vitro Kultur zur Exprimierung von Fc-IgM-Rezeptoren auf den ursprünglichen TG-Zellen kommt. Diese Veränderung der Fc-Rezeptoren führt auch zur Änderung der Funktionellen Fähigkeit der TG-Zellen, da nach Modulation AntikÖrper vermittelte Zytotoxizität und Suppressions-Fähigkeit stark vermindert sind. Diese Untersuchungen erlauben den Schluß, daß Exprimierung von Fc-IgG und FC-IgM Rezeptoren charakteristisch sind für verschiedene Funktionsstufen von T-Zellen. IgG-Immunkomplexkontakt mit dem Fc-IgG Rezeptor scheint eine Methode zu sein, diese Funktionsstadien zu verändern.

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    Werner J. Pichler

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Pichler, W.J. Bedeutung von Fc-IgG und Fc-IgM Rezeptoren auf menschlichen T-Lymphozyten. Klin Wochenschr 59, 99–109 (1981). https://doi.org/10.1007/BF01477352

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