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Urinary prostaglandins in human neonates: Relationship to kidney function and blood pressure

Prostaglandin-Ausscheidung im Urin bei Neugeborenen: Beziehung zu Nierenfunktion und Blutdruck

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Zusammenfassung

Auf der Suche nach einem biochemischen Parameter als Marker für die Hypertonie-Gefährdung wurde bei 172 gesunden Neugeborenen am 3. und 5. Lebenstag die Ausscheidung von PGE2 und von PGF2α gemessen und mit dem Blutdruck, der Elektrolytausscheidung sowie der Urinosmolalität verglichen. Daneben wurde der Blutdruck der Neugeborenen in Beziehung gesetzt zum Blutdruck der Mutter und zur Hypertonie-Anamnese in den Familien der Eltern.

Die PGE2-Ausscheidung stieg von 0,7 ng/mg Kreatinin am 3. Tag auf 1,5 am 5. Tag (p<0,001), während die PGF2α-Exkretion bei 2 ng/mg Kreatinin konstant blieb. Es bestand eine inverse Korrelation zwischen PGE2 und der Urinosmolalität (p<0,001), während die Kalium-Ausscheidung positiv zur PGF2α-Exkretion korreliert war (p<0,001). Am 5. Lebenstag war der systolische Blutdruck der Neugeborenen signifikant korreliert zu der PGF2α-Ausscheidung (p<0,05). Es bestand weiterhin eine positive Korrelation des systolischen Blutdrucks der Neugeborenen zum systolischen Blutdruck der Mütter (p<0,05). Der Blutdruck bei Neugeborenen mit Hypertonie in der Familienanamnese war bereits in der ersten Lebenswoche signifikant höher als der Blutdruck bei Kindern ohne Hypertonie bei Eltern und/oder Großeltern.

Die Untersuchungen deuten darauf hin, daß beim Neugeborenen renale Prostaglandine bei der Regulation der Urinosmolalität und der Kalium-Ausscheidung beteiligt sind. Die positive Korrelation zwischen PGF2α-Ausscheidung und Blutdruck wird als möglicher Marker eines genetisch determinierten Einflusses des renalen PG-Systems auf die Blutdruckregulation gedeutet.

Summary

We studied the excretion of prostaglandin (PG) E2 and of PGF2α in 172 healthy newborns during the first week of life to detect possible biochemical markers for the individual susceptibility to hypertension. PG excretion was compared to urinary electrolytes, urinary osmolality, and blood pressure. In addition, blood pressure of the newborns was related to the blood pressure of the mothers and to the history of hypertension in parents and/or grandparents.

PGE2-excretion increased from 0.7 ng/mg creatinine on the third day to 1.5 ng on the fifth day of life (p<0.001) while PGF2α excretion remained unchanged at 2 ng/mg creatinine. PGE2 (but not PGF2α) was inversely correlated to urinary osmolality (p<0.001) while urinary potassium was positively correlated to PGF2α (p<0.001). On the fifth day of life systolic blood pressure of the newborns was correlated to PGF2α-excretion and to systolic blood pressure of the mother (p<0.05). Blood pressure was significantly higher in newborns with a history of hypertension in parents or grandparents than in those without hypertension in relatives (p<0.02).

The data suggest that renal PG:s are involved in the regulation of urinary osmolality and potassium excretion in the neonate. The positive correlation between PGF2α excretion and blood pressure may indicate a genetically determined PG-related renal influence on the level of systemic blood pressure.

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Authors and Affiliations

  1. Medizinische Klinik Innenstadt der Universität München, Ziemssenstr. 1, D-8000, München 2, Germany

    B. Scherer, B. Friedmann, A. Dumbs, K. Holzmann & P. C. Weber

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  1. B. Scherer
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  2. B. Friedmann
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  3. A. Dumbs
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  4. K. Holzmann
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  5. P. C. Weber
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Supported by the Deutsche Forschungsgemeinschaft (Sche 118/3–5)

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Scherer, B., Friedmann, B., Dumbs, A. et al. Urinary prostaglandins in human neonates: Relationship to kidney function and blood pressure. Klin Wochenschr 58, 449–455 (1980). https://doi.org/10.1007/BF01476799

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  • DOI: https://doi.org/10.1007/BF01476799

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