Zusammenfassung
Somatostatin (250 µg als Bolus i.v. und 250 µg als Dauerinfusion über eine Stunde) wurde 5 Patienten mit Nebennierenrindeninsuffizienz verschiedener Ätiologie gegeben. Bei jedem Patienten wurde ein anhaltender, kontinuierlicher Abfall des Plasma-ACTH während der Infusionsperiode beobachtet. Die durchschnittliche maximale Verminderung des Plasma-ACTH betrug 43,8±5,9%. Nach Beendigung der Somatostatininfusion stieg das Plasma-ACTH innerhalb einer halben Stunde wieder auf den Ausgangswert an. Diese Ergebnisse zeigen, daß Somatostatin ein potenter Inhibitor der ACTH-Sekretion ist, jedoch nur bei einem bestehenden Mangel an Glucokortikoiden.
Summary
Somatostatin (250 µg as a bolus i.v. and 250 µg as a 1-hr infusion) was administered to 5 patients with adrenal insufficiency of different origin. In each patient a sustained, progressive fall in plasma ACTH was observed during the infusion period. The mean maximal reduction in plasma ACTH was 43.8±5.9%. After cessation of the somatostatin infusion there was a rise of plasma ACTH to starting levels within 1/2 hour. These findings suggest that somatostatin is a potent inhibitor of ACTH secretion, however, only in a condition in which glucocorticoids are lacking.
This is a preview of subscription content, log in via an institution to check access.
References
Alberti, K.G.M.M., Christensen, S.E., Iversen, J., Seyer-Hansen, K., Christensen, N.J., Hansen, A.P., Lundbeak, K., Ørshov, H.: Inhibition of Insulin secretion by somatostatin. Lancet I, 1299 (1973)
Besser, G.M., Mortimer, C.H., McNeilly, A.S., Thorner, M.O., Batistoni, G.A., Bloom, S.R., Kastrup, K.W., Hanssen, K.F., Hall, R., Coy, D.H., Kastin, A.J., Schally, A.V.: Long-term infusion of growth hormone release inhibiting hormone in acromegaly: Effects on pituitary and pancreatic hormones. Brit. med. J.4, 622 (1974)
Burgus, R., Ling, N., Butcher, M., Guillemin, R.: Primary structure of somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone. Proc. nat. Acad. Sci. (Wash.)70, 684 (1973)
Gerich, J.E., Lorenzi, M., Schneider, V., Forsham, P.H.: Effect of somatostatin on plasma glucose and insulin response to glucagon and tolbutamide in man. J. clin. Endocr.39, 1057 (1974a)
Gerich, J.E., Lorenzi, M., Schneider, V., Karam, J.H., Rivier, J., Guillemin, R., Forsham, P.H.: Effect of somatostatin on plasma glucose and glucagon levels in human diabetes mellitus. New Engl. J. Med.291, 544 (1974b)
Hall, R., Besser, G.M., Schally, A.V., Coy, D.H., Evered, D., Goldie, K.J., Kastin, A.J., McNeilly, A.S., Mortimer, C.H., Phenekos, C., Turnbridge, W.M., Weightman, D.: Action of growth-hormone-release inhibitory hormone in healthy men and in acromegaly. LancetII, 581 (1973)
Mortimer, C.H., Carr, D., Lind, T., Bloom, S.R., Mallinson, C.N., Schally, A.V., Turnbridge, W.M.G., Yeomans, L., Loy, D.H., Kastin, A.J., Besser, G.M., Hall, R.: Effects of growth hormone release inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic and hypopituitary patients. LancetI, 697 (1974)
Raptis, S., Dollinger, H.C., von Berger, L., Schlegel, W., Schröder, K.E., Pfeiffer, E.F.: Effects of somatostatin on gastric secretion and gastrin release in man. Digestion,13, 15 (1975)
Tyrrell, J.B., Lorenzi, M., Gerich, J.E., Forsham, P.H.: Inhibition by somatostatin of ACTH secretion in Nelson's syndrome. J. clin. Endocr.40, 1125 (1975)
Vale, W., Rivier, C., Brazeau, P., Guillemin, R.: Effects of somatostatin on the secretion of thyreotropin and prolactin. Endocrinology95, 968 (1974)
Voigt, K.H., Fehm, H.L., Reck, R., Pfeiffer, E.F.: Spontaneous and stimulated secretion of QUSO-extractable immunoassayable ACTH in man. Klin. Wschr.52, 516 (1974)
Yen, S.S.C., Siler, T.M., DeVane, G.W.: Effect of somatostatin in patients with acromegaly. New Engl. J. Med.290, 935 (1974)
Author information
Authors and Affiliations
Additional information
Supported by Deutsche Forschungsgemeinschaft Bad Godesberg SFB 87, Endokrinologie, Ulm.
Rights and permissions
About this article
Cite this article
Fehm, H.L., Voigt, K.H., Lang, R. et al. Somatostatin: A potent inhibitor of ACTH-Hypersecretion in adrenal insufficiency. Klin Wochenschr 54, 173–175 (1976). https://doi.org/10.1007/BF01468882
Issue Date:
DOI: https://doi.org/10.1007/BF01468882