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Aggressive Emperipolese bei chronischen Hepatitiden

Aggressive emperipolesis in chronic hepatitis

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Summary

The penetration and destruction of hepatocytes by lymphocytes (aggressive emperipolesis) has been described and examined quantitatively in biopsy specimens of chronic hepatitis. In 48 cases of chronic persistent hepatitis, the aggressive emperipolesis was rare and, obviously, not of great importance; sometimes there was no emperipolesis at all. In 36 cases of chronic aggressive hepatitis, however, emperipolesis was always evident, usually even to a very high extent.

The aggressive emperipolesis — as well as the piecemeal necrosis — is a significant phenomenon which can be seen in the light microscope in liver biopsies and gives evidence to the fact that this chronic inflammatory process is a progressive one; furthermore, it is an additional criterion to differentiate the two main types of chronic hepatitis.

Zusammenfassung

In Biopsiepräparaten von chronischen Hepatitiden wurde die Penetration und Zerstörung von Hepatocyten durch Lymphocyten (aggressive emperipolese) beschrieben und quantitativ ermittelt. Bei den untersuchten 48 Fällen von chronisch-persistierender Hepatitis spielte die aggressive Emperipolese nur eine untergeordnete Rolle und fehlte in vielen Fällen gänzlich. Demgegenüber ist sie bei den 36 untersuchten Fällen von chronischaggressiver Hepatitis stets deutlich, mitunter sogar in erheblichem Ausmaß vorhanden.

Die aggressive Emperipolese ist — neben den Mottenfraßnekrosen — ein morphologisches, im Leberstanzzylinder lichtmikroskopisch nachweisbares Substrat für den Prozeß der „self-perpetuation“ des chronisch-entzündlichen Geschehens und ein weiteres Kriterium für die Abgrenzung der beiden Haupttypen der chronischen Hepatitis.

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Literatur

  1. Able, M.E., Lee, J.C., Rosenau, W.: Lymphocyte-target cell interaction in vitro. Amer. J. Path.60, 421–427 (1970)

    PubMed  Google Scholar 

  2. Cossel, L., Mahnke, P.F., Schwarzer, R.: Killer-Lymphocytes in action? Light and electron microscopical findings in orthotopic liver homografts. Virchows Arch., Abt. A,364, 179–190 (1974)

    Google Scholar 

  3. De Groote J., Desmet, V.J., Gedigk, P., Korb, G., Popper, H., Poulsen, H., Scheuer P.J., Schmid, M., Thaler, H., Uehlinger, E., Wepler, W.: A classification of chronic hepatitis. Lancet 1968/II, 626–628

    Google Scholar 

  4. Dudley, F.J., Giustino, V., Sherlock, S.: Cell-mediated immunity in patients positive for hepatitis-associated antigen. Brit. Med. J. 1972/IV, 754–756

    Google Scholar 

  5. Dudley, F.J., Sherlock, S., Fox, R.A.: Cellular immunity and hepatitis-associated, australia antigen liver disease. Lancet 1972/I, 723–726

    Google Scholar 

  6. Eddleston, A.L.W., Williams, R.: Inadequate antibody response to HB-Ag or suppressor T-cell defect in development of active chronic hepatitis. Lancet 1974/II, 1543–1545

    Google Scholar 

  7. Fischer, H., Ax, W., Malchow, H., Zeiss, I.: Studies on the cytotoxicity of lymphocytes. In: Current problems in immunology. 113–120. Berlin, Heidelberg, New York: Springer (1969)

    Google Scholar 

  8. Giustino, V., Sherlock, S., Dudley, F.J.: Thymus-dependent lymphocyte function in patients with hepatitis-associated antigen. Lancet 1972/II, 850–852

    Google Scholar 

  9. Granger, G.A.: Mechanisms of lymphocyte induced cell and tissue destruction in vitro. Amer. J. Path.60, 469–481 (1970)

    PubMed  Google Scholar 

  10. Granger, G.A., Williams, T.W.: Lymphocyte cytotoxicity in vitro: activation and release of a cytotoxic factor. Nature218, 1253–1254 (1968)

    PubMed  Google Scholar 

  11. Henney, Ch.S.: Killer-T-cells. New Engl. J. Med.291, 1357–1358 (1974)

    PubMed  Google Scholar 

  12. Humble, K., Jayne, W., Pulvertaft, R.: Biological interaction between lymphocytes and other cells. Brit. J. Haemat.2, 283–305 (1956)

    PubMed  Google Scholar 

  13. Irvine, W.J., Muir, A.R.: An electron microscopic study of Hashimoto thyreoiditis. Quart. J. Exper. Physiol.48, 13–26 (1963)

    Google Scholar 

  14. Joachim, H.L.: Emperipolesis of lymphoid cells in mixed cultures. Lab. Invest.14, 1728–1794 (1965)

    Google Scholar 

  15. Knolle, J., Meyer zum Büschenfelde, K.H., Bolte, J.P., Berger, J.: Zelluläre Immunreaktionen gegenüber dem hepatitis-assoziierten Antigen (HAA) und homologem leberspezifischen Protein (HLP) bei akuten HAA-positiven Hepatitiden. Klin. Wschr.51, 1172–1174 (1973)

    PubMed  Google Scholar 

  16. Kolb, W.P., Granger, G.A.: Lymphocyte in vitro cytotoxicity: Characterization of human lymphotoxin. Proc. Nat. Acad. Sci.61, 1250–1255 (1968)

    PubMed  Google Scholar 

  17. Mackay, I.R.: Etiology of chronic hepatitis. In: The liver and its disease. Hrsg.: Schaffner, F., Sherlock, S., and Levy, C.M. 191–198. Stuttgart: Thieme (1974)

    Google Scholar 

  18. Mackay, I.R., Popper, H.: Immunopathogenesis of chronic hepatitis. Aust. NZ. J. Med.1, 79–88 (1973)

    Google Scholar 

  19. Mackay, I.R., Wood, I.J.: Autoimmunity in liver diseases. In: Popper, H., and Schaffner, F.: Progress in liver disease1, 39–55. New York-London: Grune and Stratton (1961)

    Google Scholar 

  20. Meyer zum Büschenfelde, K.H., Knolle, J., Berger, J.: Zelluläre Immunreaktionen gegenüber homologem leberspezifischem Antigen (HLP) bei chronischen Leberentzündungen. Klin. Wschr.52, 246–248 (1974)

    PubMed  Google Scholar 

  21. Paronetto, F., Vernace, S., Gerber, M.: Lymphocyte cytotoxicity in patients with chronic active hepatitis (CAH): tissue culture studies using autologous liver cells. Gastroenterology64, A-203/889 (1973)

  22. Popper, H., Mackay, I.R.: Relation between australia antigen and autoimmune hepatitis. Lancet 1972/I, 1161–1163

    Google Scholar 

  23. Popper, H., Paronetto, F.: Immunologic hepatic injury. Verh. dtsch. Ges. inn. Med.78, 790–797 (1972)

    PubMed  Google Scholar 

  24. Popper, H., Schaffner, F.: Die Leber. Struktur und Funktion. Stuttgart: Thieme (1961)

    Google Scholar 

  25. Popper, H., Schaffner, F.: The problem of chronicity in liver disease. In: Progress in liver disease. Hersg.: Popper, H., und Schaffner, F.2, 519–538. New York-London: Grune and Stratton (1965)

    Google Scholar 

  26. Richters, A., Sherwin, R.P.: The behavior of lymphocytes in primary explants of human lung cancer in vitro. Lab. Invest.13, 1520–1529 (1964)

    PubMed  Google Scholar 

  27. Schaffner, F., Barka, T., Popper, H.: Hepatic mesenchymal cell reaction in liver disease. Exper. Mol. Path.2, 419–441 (1963)

    Google Scholar 

  28. Schuhmacher, K.: Immunpathologische Phänomene bei chronischer Leberentzündung. Mat. Med. Nordmark23, 156–167 (1971)

    Google Scholar 

  29. Schuhmacher, K.: Immunpathologie der chronischen Hepatitis. Stuttgart: Thieme (1975).

    Google Scholar 

  30. Sherwin, R.P., Richters, A.: Pathobiology of lymphocyte interactions. Pathol. Ann.8, 379–406 (1973)

    Google Scholar 

  31. Thomson, A.D., Cochrane, M.A.G., McFarlane, I.G., Eddleston, A.L.W., Williams, R.: Lymphocyte cytotoxicity to isolated hepatocytes in chronic active hepatitis. Nature252, 721–722 (1974)

    PubMed  Google Scholar 

  32. Tolentino, P., Pasino, M., Braito, A., Astaldi, A., Ciacchino, R.: Impaired T-lymphocyte function in chronic hepatitis? Abstr. 9th Meeting of the EASL. In: Digestion10, 133 (1974)

    Google Scholar 

  33. Waksman, B.H.: Cytotoxic reactions of lymphocytes. In: Mechanisms of cell-mediated immunity. Ed.: McCluskey, R.T., and St. Cohen. 135–183. New York-London-Sydney-Toronto: J. Wiley (1974)

    Google Scholar 

  34. Williams, R., Smith, M.G.M.: Auto-immune liver disease studies on pathogenesis and therapy. In: Medikamentöse Immunsuppression. 43–52. Stuttgart: Thieme (1971)

    Google Scholar 

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Authors and Affiliations

  1. Pathologisches Institut der Universität Bonn, Germany

    H. Bechtelsheimer, P. Gedigk, R. Müller & H. Klein

  2. II. Medizinische Klinik der TH, Goethestraße 20, D-5100, Aachen, Bundesrepublik Deutschland

    H. Klein

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  1. H. Bechtelsheimer
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  2. P. Gedigk
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  3. R. Müller
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  4. H. Klein
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Bechtelsheimer, H., Gedigk, P., Müller, R. et al. Aggressive Emperipolese bei chronischen Hepatitiden. Klin Wochenschr 54, 137–140 (1976). https://doi.org/10.1007/BF01468791

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