Skip to main content
SpringerLink
Log in

In-vitro inhibition by unsaturated fatty acids of the PPD- and PHA-induced lymphocyte response

In vitro-Inhibition der PPD- und PHA-induzierten lymphocytären Immunantwort durch ungesättigte Fettsäuren

  • Kurze wissenschaftliche Mitteilungen
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

The inhibitory effect of oleic, linoleic, and arachidonic acid on the lymphocyte response to PPD was studied with the macrophage electrophoretic mobility (MEM) and lymphocyte transformation tests in normal subjects. Inhibition of lymphocyte stimulation by PHA was also determined in the latter test. Our observations suggest an immunoregulatory function of unsaturated fatty acids in the serum. The results and some implications of our assumption for clinical immunology are discussed.

Zusammenfassung

Der inhibitorische Effekt der Öl-, Linolen-und der Arachidonsäure auf die lymphocytäre Immunantwort wurde mit Hilfe des Macrophage Electrophoretic Mobility (MEM)- und des Lymphocytentransformationstests untersucht. Unsere Ergebnisse lassen vermuten, daß ungesättigten Fettsäuren im Serum möglicherweise eine immunregulatorische Funktion zukommt. Aus dieser Annahme evtl. resultierende Folgerungen für die klinische Immunologie werden angedeutet.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Carnegie, P. R., Caspary, E. A., Dickinson, J. P., Field, E. J.: The macrophage electrophoretic migration (MEM) test for lymphocyte sensitization: a study of the kinetics. Clin. exp. Immunol.14, 37 (1973)

    PubMed  Google Scholar 

  2. Caspary, E. A., Field, E. J.: Specific lymphocyte sensitization in cancer: is there a common antigen in human malignant neoplasia? Brit. med. J.1971 II, 613

  3. Clausen, J., Møller, J.: Allergic encephalomyelitis induced by brain antigen after deficiency in poly-unsaturated fatty acids during myelination. Is multiple sclerosis a nutritive disorder? Acta neurol. scand.43, 375 (1967)

    PubMed  Google Scholar 

  4. Field, E. J., Caspary, E. A.: Anin vitro test for cancer? Lancet1970 II, 1337

  5. Mertin, J., Shenton, B. K., Field, E. J.: Lymphocyte reactivity in relation to unsaturated fatty acids in blood; with special reference to multiple sclerosis. J. Intern. Res. Communic.1 (5), 26 (1973)

    Google Scholar 

  6. Mertin, J., Shenton, B. K., Field, E. J.: Unsaturated fatty acids in multiple sclerosis. Brit. med. J.1973 II, 777

  7. Mertin, J., Shenton, B. K., Field, E. J.: The inhibitory effect of unsaturated fatty acids on lymphocyte-antigen interaction in patients with multiple sclerosis. A specific laboratory test for the disease? J. neurol. Sci. (in the press)

  8. Mertin, J. Hughes, D.,: Study of the inhibitory effects of fatty acids on the lymphocyte immune response. (In preparation)

  9. Millar, J. H. D., Zilkha, K. J., Langman, M. J. S., Payling Wright, H., Smith, A. D., Thompson, R. H. S.: Doubleblind trial of linoleate supplementation of the diet in multiple sclerosis. Brit. med. J.1963 I, 765

  10. Naspitz, C. K., Richter, M.: The action of phytohaemagglutininin vivo andin vitro; a review. Progr. Allergy12, 1 (1968)

    Google Scholar 

  11. Paty, D. W., Hughes, D.: Lymphocyte transformation using whole blood cultures: an analysis of responses. J. Immunol. Meth.2, 99 (1972)

    Google Scholar 

  12. Quagliata, F., Lawrence, V. J. W., Phillips-Quagliata, J. M.: Prostaglandin E1 as a regulator of lymphocyte function. Selective action on B lymphocytes and synergy with procarbazine in depression of immune responses. Cell Immunol.6, 457 (1963)

    Google Scholar 

  13. Schrade, W., Bohle, E., Biegler, R., Teicke, R., Ullrich, B.: Die Fettsäuren der Cholesterinester, Phospholipide und Triglyceride, sowie die unveresterten Fettsäuren bei Gesunden und bei Arteriosklerotikern. Klin. Wschr.38, 739 (1960)

    PubMed  Google Scholar 

  14. Sidky, Y. A., Hayward, J. S., Ruth, R. I.: Immunosuppressionin vitro by brown fat. Immunol. Communic.1 (6), 579 (1972)

    Google Scholar 

  15. Thompson R. H. S.: A biochemical approach to the problem of multiple sclerosis. Proc. roy. Soc. Med.59, 269 (1966)

    PubMed  Google Scholar 

  16. Turnell, R. W., Clarke, L. H., Burton, A. F.: Studies on the mechanism of corticosteroid-induced lymphocytolysis. Cancer Res.33, 203 (1973)

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Research Council Demyelinating Diseases Unit, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, England

    J. Mertin, D. Hughes, B. K. Shenton & J. P. Dickinson

Authors
  1. J. Mertin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Hughes
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. K. Shenton
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. P. Dickinson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mertin, J., Hughes, D., Shenton, B.K. et al. In-vitro inhibition by unsaturated fatty acids of the PPD- and PHA-induced lymphocyte response. Klin Wochenschr 52, 248–250 (1974). https://doi.org/10.1007/BF01468599

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01468599

Key words

Schlüsselwörter

Search

Navigation