Skip to main content

Advertisement

SpringerLink
Log in

Immunosuppression and neoplasia

II. Is deficient immunesurveillance the only mechanism by which immunosuppression promotes neoplasia? A speculative review

  • Übersichten
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

ALS:

antilymphocyte serum, or antilymphocytic globulin, or antithymocyte serum, respectively

DMBA:

7,12-dimethyl-benz(a)-anthracene

MCA:

3-methylcholanthrene

6-MP:

6-mercaptopurine

References

  1. Allison, A. C., Berman, L. D., Levey, R. H.: Increased tumour induction by adenovirus type 12 in thymectomized mice and mice treated with anti-lymphocyte serum. Nature (Lond.)215, 185 (1967).

    PubMed  Google Scholar 

  2. Allison, A. C., Law, L. W.: Effects of antilymphocyte serum on virus oncogenesis. Proc. Soc. exp. Biol. (N.Y.)127, 207 (1968).

    Google Scholar 

  3. Allison, A. C., Taylor, R. B.: Observations on thymectomy and carcinogenesis. Cancer Res.27, 703 (1967).

    PubMed  Google Scholar 

  4. Anderson, L. G., Talal, N.: The spectrum of benign to malignant lymphoproliferation in Sjögren's syndrome. Clin. exp. Immunol.10, 199 (1972).

    PubMed  Google Scholar 

  5. Armstrong, M. Y. K., Black, F. L., Richards, F. F.: Tumour induction by cell-free extracts derived from mice with graft versus host disease. Nature (Lond.) New Biol.235, 153 (1972).

    Google Scholar 

  6. Armstrong, M. Y. K., Gleichmann, E., Gleichmann, H., Beldotti, L., André-Schwartz, J., Schwartz, R. S.: Chronic allogeneic disease. II. Development of lymphomas. J. exp. Med.132, 417 (1970).

    PubMed  Google Scholar 

  7. Bach, M.-A., Bach, J.-F.: Activities of immunosuppressive agentsin vitro. II. Different timing of azathioprine and methotrexate in inhibition and stimulation of mixed lymphocyte reaction. Clin. exp. Immunol.11, 89 (1972).

    PubMed  Google Scholar 

  8. Baird, W. M., Sedgwick, J. A., Boutwell, R. K.: Effects of phorbol and four diesters of phorbol on the incorporation of tritiated precursors into DNA, RNA, and protein in mouse epidermis. Cancer Res.31, 1434 (1971).

    PubMed  Google Scholar 

  9. Baldwin, R. W., Prehn, R. T. (chairmen): Workshop No. 19, Tumor antigens, carcinogen induced. In: B. Amos (ed.), Prog. Immunol., First Int. Congr. Immunol., p. 1233. New York-London: Academic Press 1971.

    Google Scholar 

  10. Ball, J. K.: Immunosuppression and carcinogenesis: contrasting effects with 7,12-dimethylbenz(a)anthracene, benz(a)pyrene, and 3-methylcholanthrene. J. nat. Cancer Inst.44, 1 (1970).

    PubMed  Google Scholar 

  11. Balls, M., Ruben, L. N.: Lymphoid tumours in amphibia: a review. Progr. exp. Tumor Res. (Basel)10, 238 (1968).

    Google Scholar 

  12. Balner, H.: Immunosuppression and neoplasia. Rev. Eur. Etud. Clin. Biol.15, 599 (1970).

    PubMed  Google Scholar 

  13. Balner, H., Dersjant, H.: Neonatal thymectomy and tumor induction with methylcholanthrene in mice. J. nat. Cancer Inst.36, 513 (1966).

    Google Scholar 

  14. Balner, H., Dersjant, H.: Increased oncogenic effect of methylcholanthrene after treatment with anti-lymphocyte serum. Nature (Lond.)224, 376 (1969).

    PubMed  Google Scholar 

  15. Barker, L. R.: Experimental malaria: effects upon the immune response to different antigens. J. infect. Dis.123, 99 (1971).

    PubMed  Google Scholar 

  16. Barski, G., Mondal, S., Belehradek, J., Jr., Barbieri, D.: Search for antigenic modification in mouse cell lines spontaneously converted to malignancyin vitro. In: R. J. C. Harris (ed.), Specific tumor antigens, p. 232. Copenhagen: Munksgaard 1967.

    Google Scholar 

  17. Bartlett, G. L.: Effect of host immunity on the antigenic strength of primary tumors. J. nat. Cancer Inst.49, 493 (1972).

    PubMed  Google Scholar 

  18. Bendinelli, M.: Effect of Friend leukemia virus and Rowson-Parr virus on immunological maturation of mice. Infect. Immunity4, 1 (1971).

    Google Scholar 

  19. Berenbaum, M. C.: Effects of carcinogens on immune processes. Brit. med. Bull.20, 159 (1964).

    PubMed  Google Scholar 

  20. Berg, J. W.: The incidence of multiple primary cancers. I. Development of further cancers in patients with lymphomas, leukemias, and myeloma. J. nat. Cancer Inst.38, 741 (1967).

    PubMed  Google Scholar 

  21. Blanden, R. V.: Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum. J. exp. Med.132, 1035 (1970).

    PubMed  Google Scholar 

  22. Blanden, R. V.: Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells. J. exp. Med.133, 1074 (1971).

    PubMed  Google Scholar 

  23. Bluestein, H. G., Green, I.: Croton oil induced suppression of the immune response of guinea pigs. Nature (Lond.)228, 871 (1970).

    PubMed  Google Scholar 

  24. Borella, L.: The immunosuppressive effects of Rauscher leukemia virus upon spleen cells cultured in cell-impermeable diffusion chambers. II. Effects upon IgM and IgG immunologic memory and on response to phytohemagglutinin and stimulation with allogeneic cells. J. Immunol.107, 464 (1971).

    PubMed  Google Scholar 

  25. Burnet, F. M.: The concept of immunological surveillance. Progr. exp. Tumor Res. (Basel)13, 1 (1970).

    PubMed  Google Scholar 

  26. Casey, T. P.: Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice. Clin. exp. Immunol.3, 305 (1968).

    PubMed  Google Scholar 

  27. Ceglowski, W. S., Friedman, H.: Murine virus leukaemogenesis: relationship between susceptibility and immuno-depression. Nature (Lond.)224, 1318 (1969).

    PubMed  Google Scholar 

  28. Cerilli, G. J., Treat, R. C.: The effect of antilymphocyte serum on the induction and growth of tumor in the adult mouse. Transplantation8, 774 (1969).

    Google Scholar 

  29. Chanmougan, D., Schwartz, R. S.: Enhancement of antibody synthesis by 6-mercaptopurine. J. exp. Med.124, 363 (1966).

    PubMed  Google Scholar 

  30. Cole, L. J., Nowell, P. C.: Parental-F1 hybrid bone marrow chimeras: high incidence of donor-type lymphomas. Proc. Soc. exp. Biol. (N.Y.)134, 653 (1970).

    Google Scholar 

  31. Cremer, N. E., Taylor, D. O. N., Hagens, S. J.: Antibody formation, latency and leukemia: infection with Moloney virus. J. Immunol.96, 495 (1966).

    PubMed  Google Scholar 

  32. Dameshek, W.: The significance of autoimmune disease. In: G. E. W. Wolstenholme and R. Porter (eds.), The thymus, experimental and clinical studies, p. 476, Ciba Foundation Sympos. London: J. and A. Churchill 1966.

    Google Scholar 

  33. Defendi, V., Roosa, R. A.: The role of the thymus in carcinogenesis. In: V. Defendi, M. Metcalf (eds.), The thymus, p. 121. Philadelphia: Wistar Institute Press 1964.

    Google Scholar 

  34. Della Porta, G.: Personal communication (1972).

  35. Della Porta, G., Terracini, B.: Chemical carcinogenesis in infant animals. Progr. exp. Tumor Res. (Basel)11, 334 (1969).

    PubMed  Google Scholar 

  36. Dent, P. B., Fish, L. A., White, J. G., Good, R. A.: Chediak-Higashi syndrome: observations on the nature of the associated malignancy. Lab. Invest.15, 1634 (1966).

    PubMed  Google Scholar 

  37. Dent, P. B., Peterson, R. D. A., Good, R. A.: The relationship between immunologic function and oncogenesis. In: D. Bergsma and R. A. Good (eds.), Immunologic deficiency diseases in man. Birth defects original article series, p. 443. New York: The National Foundation 1968.

    Google Scholar 

  38. Deodhar, S. D., Kuklinca, A. G., Vidt, D. G., Robertson, A. L., Hazard, J. B.: Development of reticulum-cell sarcoma at the site of antilymphocyte globulin injection in a patient with renal transplant. New Engl. J. Med.280, 1104 (1969).

    PubMed  Google Scholar 

  39. Di Marco, A. T., Franceschi, C., Xerri, L., Prodi, G.: Depression of homograft rejection and graft-versus-host reactivity following 7,12-dimethylbenz(a)anthracene exposure in the rat. Cancer Res.31, 1446 (1971).

    PubMed  Google Scholar 

  40. Doell, R. G., De Vaux St.. Cyr, C., Grabar, P.: Immune reactivity prior to development of thymic lymphoma in C57Bl mice. Int. J. Cancer2, 103 (1967).

    PubMed  Google Scholar 

  41. Duran-Reynals, M. L.: Combined neoplastic effects of vaccinia virus and 3-methylcholanthrene. I. Studies with mice of different inbred strains. J. nat. Cancer Inst.48, 95 (1972).

    PubMed  Google Scholar 

  42. East, J.: Immunopathology and neoplasms in New Zealand Black (NZB) and SJL/J mice. Progr. exp. Tumor Res. (Basel)13, 84 (1970).

    PubMed  Google Scholar 

  43. East, J., Branca, M.: Autoimmune reactions and malignant changes in germ-free New Zealand Black mice. Clin. exp. Immunol.4, 621 (1969).

    PubMed  Google Scholar 

  44. East, J., Parrot, D. M. V., Chesterman, F. C., Pomerance, A.: The appearance of a hepatotrophic virus in mice thymectomized at birth. J. exp. Med.118, 1069 (1963).

    PubMed  Google Scholar 

  45. Eisner, E., Ley, A. B., Mayer, K.: Coombs' positive hemolytic anemia in Hodgkin's disease. Ann. intern. Med.66, 258 (1967).

    PubMed  Google Scholar 

  46. Epstein, Wm. L., Fudenberg, H. H., Reed, W. B., Boder, E., Sedgwick, R. P.: Immunologic studies in ataxia-telangiectasia. I. Delayed hypersensitivity and serum immune globulin levels in probands and first-degree relatives. Int. Arch. Allergy30, 15 (1966).

    PubMed  Google Scholar 

  47. Fisher, B., Soliman, O., Fisher, E. R.: Further observations concerning effects of antilymphocyte serum on tumor growth: with special reference to allogeneic inhibition. Cancer Res.30, 2035 (1970).

    PubMed  Google Scholar 

  48. Fisher, J. C., Davis, R. C., Mannick, J. A.: The effects of immunosuppression on the induction and immunogenicity of chemically induced sarcomas. Surgery68, 150 (1970).

    PubMed  Google Scholar 

  49. Friedman, H., Ceglowski, W. S.: Immunosuppression by tumor viruses: effects of leukemia virus infection on the immune response. In: B. Amos (ed.), Prog. Immunol., First Int. Congr. Immunol., p. 815. New York-London: Academic Press 1971.

    Google Scholar 

  50. Fulginiti, V. A., Kempe, C. H.: The implications of specific infectious susceptibilities in immune deficiency syndromes. In: P. A. Miescher (ed.), Immunopathology, 6th Int. Sympos., p. 125. Basel-Stuttgart: Schwabe & Co. 1971.

    Google Scholar 

  51. Gatti, R. A., Good, R. A.: Occurrence of malignancy in immunodeficiency diseases. Cancer (Philad.)28, 89 (1971).

    PubMed  Google Scholar 

  52. Gaugas, J. M., Chesterman, F. C., Hirsch, M. S., Rees, R. J. W., Harvey, J. J., Gilchrist, C.: Unexpected high incidence of tumours in thymectomized mice treated with anti-lymphocyte globulin and Mycobacterium leprae. Nature (Lond.)221, 1033 (1969).

    PubMed  Google Scholar 

  53. Gelzer, J., Dietrich, F. M.: Haemagglutinin production in tumour-bearing and leukaemic mice. Int. J. Cancer3, 51 (1968).

    PubMed  Google Scholar 

  54. Ghaffar, A., Krsiakova, M., Playfair, J. H. L.: Deficient cell-mediated immunity in adult NZB mice. Transplantation10, 432 (1970).

    PubMed  Google Scholar 

  55. Gleichmann, E., Gleichmann, H.: Differential immunogenicity of D- and K-end antigens and its possible significance for HL-A. Transplantation13, 180 (1972).

    PubMed  Google Scholar 

  56. Gleichmann, E., Gleichmann, H., Schwartz, R. S.: Immunologic induction of malignant lymphoma. Genetic factors in the graft versus host model. J. nat. Cancer Inst.49, 793 (1972).

    PubMed  Google Scholar 

  57. Good, R. A., Finstad, J.: Essential relationship between the lymphoid system, immunity, and malignancy. Nat. Cancer Inst. Monogr.31, 41 (1969).

    PubMed  Google Scholar 

  58. Gordon, H. A.: Morphological and physiological characterization of germfree life. Ann. N.Y. Acad. Sci.78, 208 (1959).

    PubMed  Google Scholar 

  59. Grant, G. A., Miller, J. F. A. P.: Effect of neonatal thymectomy on the induction of sarcomata in C57BL mice. Nature (Lond.)205, 1124 (1965).

    PubMed  Google Scholar 

  60. Grant, G., Roe, F. J. C., Pike, M. C.: Effect of neonatal thymectomy on the induction of papillomata and carcinomata by 3,4-benzopyrene in mice. Nature (Lond.)210, 603 (1966).

    PubMed  Google Scholar 

  61. Greenwood, B. M., Playfair, J. H. L., Torrigiani, G.: Immunosuppression in murine malaria. I. General characteristics. Clin. exp. Immunol.8, 467 (1971).

    PubMed  Google Scholar 

  62. Gunz, F. W., Angus, H. B.: Leukemia and cancer in the same patient. Cancer (Philad.)18, 145 (1965).

    PubMed  Google Scholar 

  63. Häyry, P., Rago, D., Defendi, V.: Inhibition of phytohemagglutinin- and alloantigen-induced lymphocyte stimulation by Rauscher leukemia virus. J. nat. Cancer Inst.44, 1311 (1970).

    PubMed  Google Scholar 

  64. Haran-Ghera, N., Kotler, M., Meshorer, A.: Studies on leukemia development in the SJL/J strain of mice. J. nat. Cancer Inst.39, 653 (1967).

    Google Scholar 

  65. Haran-Ghera, N., Lurie, M.: Effect of heterologous antithymocyte serum on mouse skin tumorigenesis. J. nat. Cancer Inst.46, 103 (1971).

    PubMed  Google Scholar 

  66. Hellmann, K., Hawkins, R. I., Whitecross, S.: Antilymphocytic serum and tumour dissemination. Brit. med. J.1968 II, 533.

    Google Scholar 

  67. Hellström, K. E., Hellström, I., Sjögren, H. O., Warner, G. A.: Cell-mediated immunity to human tumor antigens. In: B. Amos (ed.), Progr. Immunol., First Int. Congr. Immunol., p. 940. New York-London: Academic Press 1971.

    Google Scholar 

  68. Hirsch, M. S.: In: Discussin. Fed. Proc.29, 175 (1970).

    Google Scholar 

  69. Hirsch, M. S., Black, P. H., Tracy, G. S., Feibowitz, S., Schwartz, R. S.: Leukemia virus activation in chronic allogeneic disease. Proc. nat. Acad. Sci. (Wash.)67, 1914 (1970).

    Google Scholar 

  70. Hirsch, M. S., Murphy, F. A.: Effects of anti-thymocyte serum on Rauscher virus infection of mice. Nature (Lond.)218, 478 (1968).

    PubMed  Google Scholar 

  71. Hirsch, M. S., Murphy, F. A.: Effects of anti-lymphoid sera on viral infections. Lancet1968 II, 37.

    Google Scholar 

  72. Hitchings, G. H., Elion, G. B.: Some aspects of immunosuppression. Ann. N. Y. Acad. Sci.129, 799 (1966).

    Google Scholar 

  73. Jeejeebhoy, H. F.: In: Discussion. Fed. Proc.29, 175 (1970).

    Google Scholar 

  74. Jensen, M. K.: Effect of azathioprine on the chromosome complement of human bone marrow cells. Int. J. Cancer5, 147 (1970).

    PubMed  Google Scholar 

  75. Johnson, S.: The effect of thymectomy and of the dose of 3-methylcholanthrene on the induction and antigenic properties of sarcomas in C57Bl mice. Brit. J. Cancer22, 93 (1968).

    PubMed  Google Scholar 

  76. Joseph, R. R., Tourtellotte, C. D., Barry, W. E., Smalley, R. V., Durant, J. R.: Prolonged immunological disorder terminating in hematological malignancy: a human analogue of animal disease? Ann. intern. Med.72, 699 (1970).

    PubMed  Google Scholar 

  77. Kay, S., Frable, W. J., Hume, D. M.: Cervical dysplasia and cancer developing in women on immunosuppression therapy for renal homotransplantation. Cancer (Philad.)26, 1048 (1970).

    PubMed  Google Scholar 

  78. Keast, D.: Immunosurveillance and cancer. Lancet 1970II, 710.

    Google Scholar 

  79. Kieler, J., Radzikowski, C., Moore, J., Ulrich, K.: Tumorigenicity and isoimmunizing properties of C3H mouse cells undergoing “spontaneous” malignant conversionin vitro. J. nat. Cancer Inst.48, 393 (1972).

    PubMed  Google Scholar 

  80. Kinzel, V., Süss, R.: Über spezifische Wirkungen hyperplasiogener, tumorpromovierender Crotonölfaktoren und synthetischer Phorbolester auf Zellkulturen. Verh. dtsch. Ges. Path.55, 588 (1971).

    Google Scholar 

  81. Klein, G.: Tumor-specific transplantation antigens: G. H. A. Clowes memorial lecture. Cancer Res.28, 625 (1968).

    PubMed  Google Scholar 

  82. Krüger, G.: Störung der immunologischen Reaktionsfähigkeit als Schrittmacher zur Lymphomentstehung. Verh. dtsch. Ges. Path.55, 200 (1971).

    Google Scholar 

  83. Krüger, G. R. F., Malmgren, R. A., Berard, C. W.: Malignant lymphomas and plasmacytosis in mice under prolonged immunosuppression and persistent antigenic stimulation. Transplantation11, 138 (1971).

    PubMed  Google Scholar 

  84. Lance, E. M.: Communication in workshop No. 49, Immunosuppression: antilymphocyte serum. First Int. Congr. Immunol. (Washington) 1971.

  85. Lappé, M. A.: Failure of long-term immunologic control of 3-methylcholanthrene-induced skin tumors in the autochthonous host. J. reticuloendoth. Soc.10, 120 (1971).

    Google Scholar 

  86. Lappé, M. A., Prehn, R. T.: The predictive value of skin allograft survival times during the development of urethan-induced lung adenomas in BALB/c mice. Cancer Res.30, 1357 (1970).

    PubMed  Google Scholar 

  87. Law, L. W.: Studies of thymic function with emphasis on the role of the thymus in oncogenesis. Cancer Res.26, 551 (1966).

    PubMed  Google Scholar 

  88. Law, L. W.: Studies of the significance of tumor antigens in induction and repression of neoplastic diseases: presidential address. Cancer Res.29, 1 (1969).

    PubMed  Google Scholar 

  89. Law, L. W.: In: Discussion. Fed. Proc.29, 175 (1970).

    Google Scholar 

  90. Law, L. W., Ting, R. C.: Immunologic competence and induction of neoplasms by polyoma virus. Proc. Soc. exp. Biol. (N.Y.)119, 823 (1965).

    Google Scholar 

  91. Law, L. W., Ting, R. C., Allison, A. C.: Effects of antilymphocyte serum on induction of tumours and leukaemia by murine sarcoma virus. Nature (Lond.)220, 611 (1968).

    PubMed  Google Scholar 

  92. Leibowitz, S., Schwartz, R. S.: Malignancy as a complication of immunosuppressive therapy. Advanc. intern. Med.17, 95 (1971).

    Google Scholar 

  93. Linder, O. E. A.: Survival of skin homografts in methyl-cholanthrene-treated mice and in mice with spontaneous mammary cancers. Cancer Res.22, 380 (1962).

    PubMed  Google Scholar 

  94. Malamud, D., Gonzalez, E. M., Chiu, H., Malt, R. A.: Inhibition of cell proliferation by azathioprine. Cancer Res.32, 1226 (1972).

    PubMed  Google Scholar 

  95. Malmgren, R. A., Bennison, B. E., McKinley, J. W.: Reduced antibody titers in mice treated with carcinogenic and cancer chemotherapeutic agents. Proc. Soc. exp. Biol. (N.Y.)79, 484 (1952).

    Google Scholar 

  96. McEwan, A., Petty, L. G.: Oncogenicity of immunosuppressive drugs. Letter to the editor. Lancet1972I, 326.

  97. Merigan, T. C., Stevens, D. A.: Viral infections in man associated with acquired immunological deficiency states. Fed. Proc.30, 1858 (1971).

    PubMed  Google Scholar 

  98. Metcalf, D.: Reticular tumours in mice subjected to prolonged antigenic stimulation. Brit. J. Cancer15, 769 (1961).

    PubMed  Google Scholar 

  99. Metcalf, D.: Induction of reticular tumours in mice by repeated antigenic stimulation. Acta Un. int. cancer.19, 657 (1963).

    Google Scholar 

  100. Miller, D. G.: The association of immune disease and malignant lymphoma. Ann. intern. Med.66, 507 (1967).

    PubMed  Google Scholar 

  101. Miller, J. F. A. P., Grant, G. A., Roe, F. J. C.: Effect of thymectomy on the induction of skin tumours by 3,4-benzopyrene. Nature (Lond.)199, 920 (1963).

    PubMed  Google Scholar 

  102. Millian, S. J., Schaeffer, M.: Antibody production by mice infected with selected murine oncogenic agents. Cancer (Philad.)21, 989 (1968).

    PubMed  Google Scholar 

  103. Najarian, J.: In: Discussion. Fed. Proc.29, 206 (1970).

    Google Scholar 

  104. Nehlsen, S. L.: Prolonged administration of antithymocyte serum in mice. I. Observations on cellular and humoral immunity. Clin. exp. Immunol.9, 63 (1971).

    PubMed  Google Scholar 

  105. Nomoto, K., Takeya, K.: Immunologic properties of methylcholanthrene-induced sarcomas of neonatally thymectomized mice. J. nat. Cancer Inst.42, 445 (1969).

    PubMed  Google Scholar 

  106. Notkins, A. L., Mergenhagen, S. E., Howard, R. J.: Effect of virus infections on the function of the immune system. Ann. Rev. Microbiol.24, 525 (1970).

    Google Scholar 

  107. O'Conor, G. T.: Persistent immunologic stimulation as a factor in oncogenesis, with special reference to Burkitt's tumor. Amer. J. Med.48, 279 (1970).

    PubMed  Google Scholar 

  108. Old, L. J., Boyse, E. A., Clarke, D. A., Carswell, E. A.: Antigenic properties of chemically induced tumors. Ann. N. Y. Acad. Sci.101, 80 (1962).

    Google Scholar 

  109. Parmiani, G.: Skin-graft rejection during lymphogenesis in urethan-treated mice. J. nat. Cancer Inst.47, 569 (1971).

    PubMed  Google Scholar 

  110. Parmiani, G., Colnaghi, M. I., Della Porta, G.: Immunodepressive and leukemogenic effects of urethan in C3Hf and SWR mice. Proc. Soc. exp. Biol. (N.Y.)130, 828 (1969).

    Google Scholar 

  111. Peled, A., Haran-Ghera, N.: Immunosuppression by the radiation leukemia virus and its relation to lymphatic leukemia development. Int. J. Cancer8, 97 (1971).

    PubMed  Google Scholar 

  112. Penn, I., Starzl, T. E.: Malignant tumors arising de novo in immunosuppressed organ transplant recipients. Transplantation14, 407 (1972).

    PubMed  Google Scholar 

  113. Prehn, R. T.: Function of depressed immunologic reactivity during carcinogenesis. J. nat. Cancer Inst.31, 791 (1963).

    PubMed  Google Scholar 

  114. Prehn, R. T.: In: R. T. Smith and M. Landy (eds.), Immune surveillance, p. 451. New York-London: Academic Press 1970.

    Google Scholar 

  115. Prehn, R. T.: Immunosurveillance, regeneration and oncogenesis. Progr. exp. Tumor Res. (Basel)14, 1 (1971).

    PubMed  Google Scholar 

  116. Prehn, R. T.: The immune reaction as a stimulator of tumor growth. Science176, 170 (1972).

    PubMed  Google Scholar 

  117. Pritzker, K. P. H., Huang, S. N., Marshall, K. G.: Malignant tumours following immunosuppressive therapy. Canad. med. Ass. J.103, 1362 (1970).

    PubMed  Google Scholar 

  118. Rabbat, A. G., Jeejeebhoy, H. F.: Heterologous antilymphocyte serum (ALS) hastens the appearance of methylcholanthrene-induced tumours in mice. Transplantation9, 164 (1970).

    PubMed  Google Scholar 

  119. Reis, H. E.: Die Bedeutung der Immunsuppression für die Entstehung und das Wachstum maligner Geschwülste. Dtsch. med. Wschr.96, 170 (1971).

    PubMed  Google Scholar 

  120. Reiskin, A. B.: Cell proliferation during carcinogenesis. In: Rec. results cancer res., vol. 17, p. 128. Berlin-Heidelberg-New York: Springer 1969.

    Google Scholar 

  121. Rubin, B. A.: Alteration of the homograft response as a determinant of carcinogenicity. Progr. exp. Tumor Res. (Basel)14, 138 (1971).

    PubMed  Google Scholar 

  122. Ryser, H. J.-P.: Chemical carcinogenesis. New Engl. J. Med.285, 721 (1971).

    PubMed  Google Scholar 

  123. Sahiar, K., Schwartz, R. S.: The immunoglobulin sequence. II. Histological effects of the suppression of γM and γG antibody synthesis. Int. Arch. Allergy29, 52 (1966).

    PubMed  Google Scholar 

  124. Salaman, M. H.: Immunodepression by mammalian viruses and plasmodia. Proc. roy. Soc. Med.63, 11 (1970).

    PubMed  Google Scholar 

  125. Scherf, H. R., Krüger, C., Karsten, C.: Untersuchungen an Ratten über immunosuppressive Eigenschaften von Cytostatica unter besonderer Berücksichtigung der carcinogenen Wirkung. Arzneimittel-Forsch. (Drug Res.)20, 1467 (1970).

    Google Scholar 

  126. Schmähl, D.: Entstehung, Wachstum und Chemotherapie maligner Tumoren. 2. Aufl. Arzneimittel-Forsch. (Drug Res.) 21. Beiheft (Suppl.), p. 154ff. Aulendorf i. Württ.: Editio Cantor KG 1970.

    Google Scholar 

  127. Schmähl, D., Osswald, H.: Experimentelle Untersuchungen über carcinogene Wirkungen von Krebs-Chemotherapeutika und Immunosuppressiva. Arzneimittel-Forsch. (Drug Res.)20, 1461 (1970).

    Google Scholar 

  128. Schmähl, D., Wagner, R., Scherf, H. R.: Der Einfluß von Immunosuppressiva auf die Cancerisierung der Rattenleber durch Diäthylnitrosamin und die Fibrosarkomentstehung durch 3,4-Benzpyren. Arzneimittel-Forsch. (Drug Res.)21, 403 (1971).

    Google Scholar 

  129. Schmidt-Ruppin, K. H., Papadopulu, G.: Zur Wirkung von Diäthylnitrosamin (DAENA) und Influenza-Viren auf die Entstehung von Lungencarcinomen bei Mäusen. Z. Krebsforsch.77, 150 (1972).

    Google Scholar 

  130. Schreiber, H., Nettesheim, P., Lijinsky, W., Richter, C. B., Walburg, H. E., jr.: Induction of lung cancer in germfree, specific-pathogenfree, and infected rats by N-Nitrosoheptamethyleneimine: enhancement by respiratory infection. J. nat. Cancer Inst.49, 1107 (1972).

    PubMed  Google Scholar 

  131. Schwartz, R. S., Costea, N.: Autoimmune hemolytic anemia: clinical correlations and biological implications. Semin. Hematol.3, 2 (1966).

    PubMed  Google Scholar 

  132. Seidel, H. J., Lauenstein, K.: Zur Immunsuppression durch Leukämieviren. Untersuchungen mit dem Rauscher-Virus an einem Leukämie-resistenten Mäusestamm. Z. Krebsforsch.72, 219 (1969).

    PubMed  Google Scholar 

  133. Sheehan, R., Shklar, G., Tennenbaum, R.: Azathioprine effects on the development of hamster pouch carcinomas. Arch. Path.91, 264 (1971).

    PubMed  Google Scholar 

  134. Shklar, G., Cataldo, E., Fitzgerald, A. L.: The effect of methotrexate on chemical carcinogenesis of hamster buccal pouch. Cancer Res.26, 2218 (1966).

    PubMed  Google Scholar 

  135. Siegel, B. V., Morton, J. I.: Serum agglutinin levels to sheep red blood cells in mice infected with Rauscher virus. Proc. Soc. exp. Biol. (N.Y.)123, 467 (1966).

    Google Scholar 

  136. Siegel, B. V., Morton, J. I.: Immunologic stimuli in relation to leukemogenesis. I. Potentiation of Rauscher viral leukemia by Freund's adjuvants. J. nat. Cancer Inst.48, 1681 (1972).

    PubMed  Google Scholar 

  137. Silverberg, E., Grant, R. N.: Cancer statistics, 1970. CA.20, 11 (1970).

    Google Scholar 

  138. Simpson, E., Nehlsen, S. L.: Prolonged administration of antithymocyte serum in mice. II. Histopathological investigation. Clin. exp. Immunol.9, 79 (1971).

    PubMed  Google Scholar 

  139. Smith, R. T., Landy, M. (eds.): Immune surveillance. Proc. Int. Conf. at Brook Lodge, Augusta, Michigan. New York-London: Academic Press 1970.

    Google Scholar 

  140. Southam, C. M., Tanaka, S., Arata, T., Simkovic, D., Miura, M., Petropulos, S. F.: Enhancement of responses to chemical carcinogens by nononcogenic viruses and antimetabolites. Progr. exp. Tumor Res. (Basel)11, 194 (1969).

    PubMed  Google Scholar 

  141. Stjernswärd, J.: Further immunological studies of chemical carcinogenesis. J. nat. Cancer Inst.38, 515 (1967).

    PubMed  Google Scholar 

  142. Stjernswärd, J.: Immunosuppression by carcinogens. Antibiot. et Chemother. (Basel)15, 213 (1969).

    Google Scholar 

  143. Stutman, O.: Carcinogen-induced immune depression: absence in mice resistant to chemical oncogenesis. Science166, 620 (1969).

    PubMed  Google Scholar 

  144. Tallent, M. B., Simmons, R. L., Najarian, J. S.: Primary carcinoma of the cervix appearing in immunosuppressed renal transplant recipient. Amer. J. Obstet. Gynec.109, 663 (1971).

    PubMed  Google Scholar 

  145. ten Bensel, R. W., Stadlan, E. M., Krivit, W.: The development of malignancy in the course of the Aldrich syndrome. J. Pediat.68, 761 (1966).

    PubMed  Google Scholar 

  146. Topilsky, M., Williams, M., Siltzbach, L. E., Glade, P. R.: Lymphocyte response in sarcoidosis. Lancet1972I, 117.

  147. Trainin, N., Linker-Israeli, M., Small, M., Boiato-Chen, L.: Enhancement of lung adenoma formation by neonatal thymectomy in mice treated with 7,12-dimethylbenz(a)-anthracene or urethan. Int. J. Cancer2, 326 (1967).

    PubMed  Google Scholar 

  148. Vandeputte, M.: Antilymphocytic serum and polyoma oncogenesis in rats. Transplant. Proc.1, 100 (1969).

    PubMed  Google Scholar 

  149. Vandeputte, M., Datta, S. K.: Cell-mediated immunity in polyoma oncogenesis. Europ. J. Cancer8, 1 (1972).

    Google Scholar 

  150. van Hoosier, G. L., Jr., Gist, C., Trentin, J. J.: Enhancement by thymectomy of tumor formation by oncogenic adenoviruses. Proc. Soc. exp. Biol. (N.Y.)128, 467 (1968).

    Google Scholar 

  151. Verbin, R. S., Diluiso, G., Liang, H., Farber, E.: The effects of cytosine arabinoside upon proliferating epithelial cells. Cancer Res.32, 1476 (1972).

    PubMed  Google Scholar 

  152. Verrier Jones, J.: Development of sensitivity to dinitrochlorobenzene in patients with sarcoidosis. Clin. exp. Immunol.2, 477 (1967).

    PubMed  Google Scholar 

  153. Volkert, M., Lundstedt, C.: The provocation of latent lymphocytic choriomeningitis virus infections in mice by treatment with antilymphocytic serum. J. exp. Med.127, 327 (1968).

    PubMed  Google Scholar 

  154. Vredevoe, D. L., Hays, E. F.: Effect of antilymphocytic and antithymocytic sera on the development of mouse lymphoma. Cancer Res.29, 1685 (1969).

    PubMed  Google Scholar 

  155. Wagner, J. L., Haughton, G.: Immunosuppression by antilymphocyte serum and its effect on tumors induced by 3-methylcholanthrene in mice. J. nat. Cancer Inst.46, 1 (1971).

    PubMed  Google Scholar 

  156. Walder, B. K., Robertson, M. R., Jeremy, D.: Skin cancer and immunosuppression. Lancet1971II, 1282.

  157. Warwick, G. P.: Effect of the cell cycle on carcinogenesis. Fed. Proc.30, 1760 (1971).

    PubMed  Google Scholar 

  158. Wedderburn, N.: Effect of concurrent malarial infection on development of virus-induced lymphoma in Balb/c mice. Lancet1970II, 1114.

  159. Weston, J. T., Guin, G. H.: Epithelial atypias with chemotherapy in 100 acute childhood leukemias. Cancer (Philad.)8, 179 (1955).

    PubMed  Google Scholar 

  160. Woods, D. A.: Influence of antilymphocyte serum on DMBA induction of oral carcinomas. Nature (Lond.)224, 276 (1969).

    PubMed  Google Scholar 

  161. Zipp, P., Kountz, S. L.: Analysis of the immunosuppressive and oncogenic effects of heterologous antilymphocyte serum. Amer. J. Surg.122, 204 (1971).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Experimental Pathology and Section of Clinical Immunology and Blood Bank, Medical School Hannover, Germany

    Ernst Gleichmann & Helga Gleichmann

Authors
  1. Ernst Gleichmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Helga Gleichmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This is the second of two papers, the first one appeared in the preceding issue of this journal.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gleichmann, E., Gleichmann, H. Immunosuppression and neoplasia. Klin Wochenschr 51, 260–265 (1973). https://doi.org/10.1007/BF01467813

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01467813

Keywords

Search

Navigation